Results 11 to 20 of about 155,433 (279)

Toward a Functional Cure for Hepatitis B

Gut and Liver
Current treatment of chronic hepatitis B virus (HBV) infection, pegylated interferon-α (pegIFN-α) and nucleos(t)ide analogue (NA), can suppress HBV replication, reverse liver inflammation and fibrosis, and decrease risks of cirrhosis and hepatocellular ...
Anna S. F. Lok
doaj   +4 more sources

Functional Cure of Hepatitis B Virus Infection in Individuals With HIV-Coinfection: A Literature Review

Viruses, 2021
In individuals infected with hepatitis B virus (HBV), the loss of hepatitis B surface antigen (HBsAg) is the ultimate therapeutic goal, which defines “functional cure.” For individuals living with human immunodeficiency virus (HIV), functional cure ...
Anders Boyd, Lorenza N. C. Dezanet, Karine Lacombe   +2 more
doaj   +2 more sources

Circulating HBsAg-specific B cells are partially rescued in chronically HBV-infected patients with functional cure

Emerging Microbes and Infections
It is well established that humoral immunity targeting hepatitis B virus surface antigen (HBsAg) plays a critical role in viral clearance and clinical cure.
Shuqin Gu, Libo Tang, Ling Guo, Chunxiu Zhong, Xin Fu, Guofu Ye, Shihong Zhong, Xiaoyi Li, Chunhua Wen, Yang Zhou, Jinling Wei, Haitao Chen, Nikolai Novikov, Simon P. Fletcher, M. Anthony Moody, Jinlin Hou, Yongyin Li   +16 more
doaj   +4 more sources

Hepatitis B functional cure and immune response

Frontiers in Immunology, 2022
Hepatitis B virus (HBV) is a hepatotropic virus, which damage to hepatocytes is not direct, but through the immune system. HBV specific CD4+ T cells can induce HBV specific B cells and CD8+ T cells.
Jia-Rui Zheng, Zi-Long Wang, Bo Feng
doaj   +3 more sources

Achieving chronic hepatitis B functional cure: Factors and potential mechanisms [PDF]

Virus Research
Chronic hepatitis B (CHB) is a significant global health issue affecting approximately 254 million individuals worldwide. Achieving the loss of hepatitis B surface antigen (HBsAg), either with or without seroconversion to hepatitis B surface antibody ...
Jiarui Zheng, Yandi Xie, Bo Feng
exaly   +3 more sources

Update on the treatment navigation for functional cure of chronic hepatitis B: Expert consensus 2.0 [PDF]

Clinical and Molecular Hepatology
As new evidence emerges, treatment strategies toward the functional cure of chronic hepatitis B are evolving. In 2019, a panel of national hepatologists published a Consensus Statement on the functional cure of chronic hepatitis B.
Di Wu, Jia-Horng Kao, Teerha Piratvisuth, Xiaojing Wang, Patrick T.F. Kennedy, Motoyuki Otsuka, Sang Hoon Ahn, Yasuhito Tanaka, Guiqiang Wang, Zhenghong Yuan, Wenhui Li, Young-Suk Lim, Junqi Niu, Fengmin Lu, Wenhong Zhang, Zhiliang Gao, Apichat Kaewdech, Meifang Han, Weiming Yan, Hong Ren, Peng Hu, Sainan Shu, Paul Yien Kwo, Fu-sheng Wang, Man-Fung Yuen, Qin Ning   +25 more
doaj   +2 more sources

Functional cure of HIV: the scale of the challenge [PDF]

Nature Reviews Immunology, 2018
A variety of interventions to induce a functional cure of HIV are being explored, with the aim being to allow patients to cease antiretroviral therapy (ART) for prolonged periods of time or for life. These interventions share the goal of inducing ART-free remission from HIV pathogenesis and disease progression but achieve this in quite different ways ...
Davenport, MP, Khoury, DS, Cromer, D, Lewin, SR, Kelleher, AD, Kent, SJ   +5 more
openaire   +4 more sources

A case report: cccDNA and pgRNA remain positive in liver tissue in a chronic hepatitis B patient with functional cure [PDF]

Frontiers in Medicine
Hepatitis B surface antigen (HBsAg) seroclearance is recommended as the ideal endpoint for nucleos(t)ide analog (NA) treatments. Functional cure of chronic hepatitis B (CHB) is defined as having undetectable serum hepatitis B virus (HBV) deoxyribonucleic
Wenxiong Xu, Wenxiong Xu, Qiumin Luo, Qiumin Luo, Yeqiong Zhang, Yeqiong Zhang, Chan Xie, Chan Xie, Liang Peng, Liang Peng, Liang Peng   +10 more
doaj   +2 more sources

Functional cure of chronic hepatitis B – predictable? [PDF]

EBioMedicine, 2021
Wolfram Gerlich
doaj   +3 more sources

Functional Cure for Hepatitis B Virus: Challenges and Achievements. [PDF]

Int J Mol Sci
The Hepatitis B Virus (HBV) presents a formidable global health challenge, impacting hundreds of millions worldwide and imposing a considerable burden on healthcare systems. The elusive nature of the virus, with its ability to establish chronic infection
Shechter O, Sausen DG, Dahari H, Vaillant A, Cotler SJ, Borenstein R.   +5 more
europepmc   +2 more sources