HIV controllers: hope for a functional cure [PDF]
Frontiers in ImmunologyElite controllers (ECs) and post-treatment controllers (PTCs) represent important models for achieving a functional cure for HIV. This review synthesizes findings from immunological, genetic, and virological studies to compare the mechanisms underlying ...
Zhuoya Deng +9 more
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IL-2 and IL-15 augment HBV therapeutic vaccination and PD1 blockade for functional cure in the AAV-HBV mouse model [PDF]
Frontiers in ImmunologyIntroductionPrevalence of chronic hepatitis B virus (HBV) infection remains a major global health issue. Research into a cure has focused on finite combinatorial interventions that aim to reduce HBV surface antigen (HBsAg), suppress virus specific immune
Gavin Lewis +7 more
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Toward a Functional Cure for Hepatitis B [PDF]
Gut and LiverCurrent treatment of chronic hepatitis B virus (HBV) infection, pegylated interferon-α (pegIFN-α) and nucleos(t)ide analogue (NA), can suppress HBV replication, reverse liver inflammation and fibrosis, and decrease risks of cirrhosis and hepatocellular ...
Anna S. F. Lok
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Hepatitis B functional cure and immune response
Frontiers in Immunology, 2022 Hepatitis B virus (HBV) is a hepatotropic virus, which damage to hepatocytes is not direct, but through the immune system. HBV specific CD4+ T cells can induce HBV specific B cells and CD8+ T cells.
Jia-Rui Zheng, Zi-Long Wang, Bo Feng
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Targeting the innate immune system in treating hepatitis B: prospects for functional cure [PDF]
Clinical and Molecular HepatologyChronic hepatitis B (CHB) infection remains a significant global public health concern. Functional cure, defined as hepatitis B surface antigen seroclearance with unquantifiable HBV DNA at 24 weeks off treatment, is a desirable endpoint in the treatment ...
Karen Cheuk-Ying Ho +4 more
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Broken Symmetry in Density-Functional Theory: Analysis and Cure [PDF]
Physical Review B, 2003 We present a detailed analysis of the broken-symmetry mean-field solutions using a four-electron rectangular quantum dot as a model system. Comparisons of the density-functional theory predictions with the exact ones show that the symmetry breaking ...
A. Harju +16 more
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Determinants of functional cure in interferon-treated chronic hepatitis B: a retrospective cohort analysis of HBsAg dynamics and clinical predictors [PDF]
Frontiers in Cellular and Infection MicrobiologyBackground and ObjectivesFunctional cure of chronic hepatitis B (CHB) is the optimal goal of antiviral therapy. This study evaluates the functional cure rates in a large cohort treated with interferon (IFNα) and explores baseline predictors to optimize ...
Daqiong Zhou +6 more
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Update on the treatment navigation for functional cure of chronic hepatitis B: Expert consensus 2.0 [PDF]
Clinical and Molecular HepatologyAs new evidence emerges, treatment strategies toward the functional cure of chronic hepatitis B are evolving. In 2019, a panel of national hepatologists published a Consensus Statement on the functional cure of chronic hepatitis B.
Di Wu +25 more
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Functional cure of chronic hepatitis B – predictable? [PDF]
EBioMedicine, 2021 Wolfram Gerlich
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