Results 21 to 30 of about 412,466 (343)

Functional Cure for Hepatitis B Virus: Challenges and Achievements. [PDF]

Int J Mol Sci
The Hepatitis B Virus (HBV) presents a formidable global health challenge, impacting hundreds of millions worldwide and imposing a considerable burden on healthcare systems. The elusive nature of the virus, with its ability to establish chronic infection and evade immune detection, and the absence of curative agents have prompted efforts to develop ...
Shechter O, Sausen DG, Dahari H, Vaillant A, Cotler SJ, Borenstein R.   +5 more
europepmc   +3 more sources

Machine learning prediction of functional cure to pegylated interferon-alpha therapy in two HBV populations: Advantaged populations and HBeAg-negative patients. [PDF]

Virulence
Li J, Li H, Lin C, Jiang R, Wang L, He Y, Yang X, Gong K, Xun Z, Zheng Q.   +9 more
europepmc   +2 more sources

Functional cure of chronic hepatitis B encounters resmetirom [PDF]

Clinical and Molecular Hepatology
Nai-Bin Yang, Wai-Kay Seto, Ming-Hua Zheng   +2 more
doaj   +3 more sources

Traditional and Novel Virologic Markers for Functional Cure and HBeAg Loss with Pegylated Interferon in Chronic Hepatitis B: A Systematic Review and Meta-analysis. [PDF]

J Clin Transl Hepatol
Zhang Y, Wang LF, Chen J, Nguyen MH, Zheng Q.   +4 more
europepmc   +3 more sources

Functional molecular expression of nature killer cells correlated to HBsAg clearance in HBeAg-positive chronic hepatitis B patients during PEG-IFN α-2a therapy

Frontiers in Immunology, 2022
ObjectiveTo explore whether the frequencies and functional molecules expression of Natural Killer cells (NK cells) are related to hepatitis B surface antigen (HBsAg) disappearance in hepatitis B e envelope antigen (HBeAg)-positive patients with chronic ...
Weihua Cao, Weihua Cao, Huihui Lu, Huihui Lu, Luxue Zhang, Luxue Zhang, Shiyu Wang, Wen Deng, Tingting Jiang, Yanjie Lin, Liu Yang, Xiaoyue Bi, Yao Lu, Lu Zhang, Ge Shen, Ruyu Liu, Min Chang, Shuling Wu, Yuanjiao Gao, Hongxiao Hao, Mengjiao Xu, Xiaoxue Chen, Leiping Hu, Yao Xie, Yao Xie, Minghui Li, Minghui Li   +26 more
doaj   +1 more source

Small nucleic acid drugs-the dawn of functional cure of chronic hepatitis B. [PDF]

Front Pharmacol
Zhang L, Cao Y, Zhuang S, Sun J, Tong Q, Xi J, Liu S, Zhuang R.   +7 more
europepmc   +3 more sources

Patient acceptability of, and attitudes towards, hepatitis B cure research – A scoping review and identification of knowledge gaps

Journal of Virus Eradication, 2023
Functional cure, defined as durable loss of hepatitis B surface antigen (HBsAg) and hepatitis B virus (HBV) DNA suppression off therapy, is an increasingly important goal in the treatment of chronic hepatitis B.
Neaka Mohtashemi, Karine Dubé, Chloe Thio, Sihyeong Song, Shail Patel, Jeremy Sugarman, Debika Bhattacharya   +6 more
doaj   +1 more source

Functional Cure of Hepatitis B Virus Infection in Individuals With HIV-Coinfection: A Literature Review

Viruses, 2021
In individuals infected with hepatitis B virus (HBV), the loss of hepatitis B surface antigen (HBsAg) is the ultimate therapeutic goal, which defines “functional cure.” For individuals living with human immunodeficiency virus (HIV), functional cure ...
Anders Boyd, Lorenza N. C. Dezanet, Karine Lacombe   +2 more
doaj   +1 more source

Expression of Functional Molecule on Plasmacytoid Dendritic Cells Is Associated With HBsAg Loss in HBeAg-Positive Patients During PEG-IFN α-2a Treatment

Frontiers in Immunology, 2022
ObjectiveThe ideal endpoint of antiviral therapy in chronic hepatitis B (CHB) patients is to clear hepatitis B surface antigen (HBsAg). This study aimed to evaluate whether the expression of functional molecules on plasmacytoid dendritic cells (pDCs) is ...
Weihua Cao, Weihua Cao, Si Xie, Lu Zhang, Xiaoyue Bi, Yanjie Lin, Liu Yang, Yao Lu, Ruyu Liu, Min Chang, Shuling Wu, Ge Shen, Jianping Dong, Yao Xie, Yao Xie, Minghui Li, Minghui Li   +16 more
doaj   +1 more source

Neutrophil function in cured cancer patients [PDF]

Cancer, 1977
Spontaneous and endotoxin-stimulated nitroblue tetrazolium (NBT) dye reduction was evaluated in 86 individuals cured of various types of solid malignancies and in 55 healthy adults. Oxygen consumption tests, at rest and during phagocytosis, were performed with polymorphonuclear leukocytes of 22 patients and 10 controls, chosen at random.
N, Haim, N, Obedeanu, T, Meshulam, E, Robinson, H, Schreiber, D, Merzbach   +5 more
openaire   +2 more sources