Results 21 to 30 of about 155,433 (279)
Towards a functional cure for chronic hepatitis B [PDF]
, 2023 Chronic hepatitis B (CHB) is an infectious disease caused by the bloodborne hepatitis B virus in patients that do not spontaneously clear the virus after infection.
Erken, R.
core +5 more sources
Frontiers in Immunology, 2022 ObjectiveThe ideal endpoint of antiviral therapy in chronic hepatitis B (CHB) patients is to clear hepatitis B surface antigen (HBsAg). This study aimed to evaluate whether the expression of functional molecules on plasmacytoid dendritic cells (pDCs) is ...
Weihua Cao +16 more
doaj +1 more source
BMC Infectious Diseases, 2022 Background Human immunodeficiency virus (HIV) functional cure is a novel biomedical strategy characterized by sustained viral suppression without the need for life-long medications.
Tsz Ho Kwan +3 more
doaj +1 more source
JHEP Reports, 2023 Background & Aims: Antivirals represent the mainstay of chronic hepatitis B treatment given their efficacy and tolerability, but rates of functional cure remain low during long-term therapy.
Georgia Zeng +4 more
doaj +1 more source
Neutrophil function in cured cancer patients [PDF]
Cancer, 1977 Spontaneous and endotoxin-stimulated nitroblue tetrazolium (NBT) dye reduction was evaluated in 86 individuals cured of various types of solid malignancies and in 55 healthy adults. Oxygen consumption tests, at rest and during phagocytosis, were performed with polymorphonuclear leukocytes of 22 patients and 10 controls, chosen at random.
N, Haim +5 more
openaire +2 more sources
Analysis of HBsAg Immunocomplexes and cccDNA Activity During and Persisting After NAP‐Based Therapy
Hepatology Communications, 2021 Therapy with nucleic acid polymers (NAPs), tenofovir disoproxil fumarate (TDF), and pegylated interferon (pegIFN) achieve high rates of HBsAg loss/seroconversion and functional cure in chronic hepatitis B virus (HBV) infection.
Michel Bazinet +17 more
doaj +1 more source
Cold-Curing Structural Epoxy Resins: Analysis of the Curing Reaction as a Function of Curing Time and Thickness [PDF]
Materials, 2014 The curing reaction of a commercial cold-curing structural epoxy resin, specifically formulated for civil engineering applications, was analyzed by thermal analysis as a function of the curing time and the sample thickness. Original and remarkable results regarding the effects of curing time on the glass transition temperature and on the residual heat ...
ESPOSITO CORCIONE, Carola +2 more
openaire +2 more sources
Predictive biomarkers of a functional cure for HIV [PDF]
, 2019 Abstract: Although combination antiretroviral therapy (cART) is very effective at suppressing viral replication and preventing disease progression, it is not curative due to the existence of a latent viral reservoir in resting memory CD4+ T cells. As a result, HIV infected patients need to take life-long antiretroviral therapy.
Pannus, Pieter
openaire +1 more source
Moving Toward a Functional Cure for HIV-1
Infectious Diseases & Immunity, 2021 . Despite the recent success of suppressing human immunodeficiency virus 1 (HIV-1) replication in the peripheral blood with antiretroviral therapy, elimination of the provirus from infected cells remains challenging because the virus can integrate into ...
Wen Kang, Yongtao Sun, Haijuan Wang
doaj +1 more source
Current status and future prospects of drug treatment strategies for functional cure of chronic hepatitis B [PDF]
Zhenduanxue lilun yu shijianChronic hepatitis B (CHB) remains a major global health challenge. Functional cure represents the ideal therapeutic endpoint for CHB. The pathogenesis of CHB is complex, including hepatitis B virus (HBV) DNA integration, persistent covalently closed ...
LI Qiang, CHEN Liang
doaj +1 more source