Results 51 to 60 of about 3,358,253 (225)

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

A Cure for HIV Infection: “Not in My Lifetime” or “Just Around the Corner”?

Pathogens and Immunity, 2016
With the advent and stunning success of combination antiretroviral therapy (ART) to prolong and improve quality of life for persons with HIV infection, HIV research has been afforded the opportunity to pivot towards studies aimed at finding “a cure.” The
Michael M. Lederman, Paula M. Cannon, Judith S. Currier, Carl H. June, Hans-Peter Kiem, Daniel R. Kuritzkes, Sharon R. Lewin, David M. Margolis, Joseph M. McCune, John W. Mellors, Timothy W. Schacker, Rafick P. Sekaly, Pablo Tebas, Bruce D. Walker, Daniel C. Douek   +14 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Toward a Functional Cure for Hepatitis B

Gut and Liver
Current treatment of chronic hepatitis B virus (HBV) infection, pegylated interferon-α (pegIFN-α) and nucleos(t)ide analogue (NA), can suppress HBV replication, reverse liver inflammation and fibrosis, and decrease risks of cirrhosis and hepatocellular ...
Anna S. F. Lok
doaj   +1 more source

CURE Portal (CURE Deliverable D4.5)

, 2022
This document accompanies the Deliverable D4.5 – the CURE Portal – a final delivery of activities in Task 4.5. It summarizes main elements of concept and provides overview of a final implementation of the web-based portal, demonstrating the capacity and ...
Opletal, Michal, Kopecky, Miroslav, Dubrovsky, Vojtech, Schmid, Johannes, Soukup, Tomas, Jupova, Katerina, Vlach, Pavel, Dohr, Mario, Babic, Martin   +8 more
core   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

CURE Published Material (CURE Deliverable D7.8)

, 2023
This document provides an overview of the published material of the CURE project (Copernicus for Urban Resilience in Europe). This material is result of core project (research), communication or dissemination activities, has served as tool for efficient ...
Somarakis, Giorgos, Mitraka, Zina, Chrysoulakis, Nektarios   +2 more
core   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source