Results 41 to 50 of about 34,526 (257)
The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation
FEBS Letters, EarlyView.Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge +6 more
wiley +1 more source
Membrane composition and thermodynamic identity as boundaries of life for synthetic cell research
FEBS Letters, EarlyView.What makes a cell a cell? The boundary of a living cell is not just a wall. Read as a Markov blanket, the membrane separates internal from external states, generating identity and non‐equilibrium order. Can this identity be rebuilt from scratch in a synthetic cell?
Caterina Presutti, Bert Poolman
wiley +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
HIV-2 infection as a comparative lens for functional HIV-1 remission
Frontiers in ImmunologyFour decades into the HIV pandemic, HIV-2 infection remains an underutilized comparative resource for HIV-1 cure research. HIV-2 is associated with lower plasma viral loads, slower CD4+ T-cell decline, and delayed disease progression in many individuals.
Sabastine Eugene Arthur +10 more
doaj +1 more source
Small RNA zippers lock miRNA molecules and block miRNA function in mammalian cells
Nature Communications, 2017 MicroRNAs regulate a wide range of biological processes and being able to inhibit their function could allow the development of therapeutic options.
Lingyu Meng +16 more
doaj +1 more source
Frontiers in Microbiology, 2017 Despite combination antiretroviral therapy (cART), acquired immunodeficiency syndrome (AIDS), predominantly caused by the human immunodeficiency virus type 1 (HIV-1), remains incurable.
Maxime J. Jean +11 more
doaj +1 more source
Vestnik travmatologii i ortopedii imeni N.N. Priorova, 2016 Results of the comparative study of the efficacy and safety of one- and two-level brachial plexus block (BPB) at locking intramedullary shoulder osteosynthesis are presented. Fifty five patients (mean age 43.4±3.2 years) with humeral diaphysis fracture were operated on.
V. B Dubinenkov +4 more
openaire +1 more source
Molecular Oncology, EarlyView.Extracellular vesicle (EV) lipidomic profiling of plasma and ascites from patients with high‐grade serous ovarian cancer and of ovarian cancer cell lines reveals enrichment of triglycerides (TGs), diacylglycerols (DGs), phosphatidylcholine (PCs), sphingomyelins (SMs), reflecting tumor metabolic reprogramming.
Shikha Rani +9 more
wiley +1 more source
Analysis on Locking Mechanism Performance of SCM Running Tool for Subsea Horizontal X-tree
Shiyou jixie, 2016 The locking element is the most significant part of the whole SCMRT.In the theoretical analysis,locking angle,unlocking angle and cone angle are mainly considered for the lock block.Self-locking would not occur when the lock angle α is larger than 8.5 ...
Zhang Kailong +4 more
doaj
Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation
Molecular Oncology, EarlyView.How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim +11 more
wiley +1 more source