Results 31 to 40 of about 34,722 (290)
mBio, 2018 The main obstacle to an HIV cure is the transcriptionally inert proviruses that persist in resting CD4 T cells and other reservoirs. None of the current approaches has significantly reduced the size of the viral reservoir.
George B. Kyei +6 more
doaj +1 more source
Head & Face Medicine, 2021 Background Temporomandibular joint (TMJ) ‘closed lock’ is a clinical condition causing TMJ pain and limited mouth opening (painful locking). Recent studies suggest an increasing prevalence of degenerative joint disease associated with the onset of TMJ ...
Hongzhi Zhou, Yang Xue, Ping Liu
doaj +1 more source
Locked-in syndrome during stellate ganglion block
Indian Journal of Anaesthesia, 2010 Intra-arterial injection of a local anaesthetic during stellate ganglion blockade may cause life-threatening complications. The usual complications are apnoea, unconsciousness and seizures. However, occasionally an unusual complication, 'locked-in' syndrome, has also been reported.
A Chaturvedi, H H Dash
openaire +3 more sources
Biomolecules, 2023 The “block and lock” strategy is one approach that might elicit a sterilizing cure for HIV-1 infection. The “block” refers to a compound’s ability to inhibit latent HIV-1 proviral transcription, while the “lock” refers to its capacity to induce permanent
Benni Vargas +3 more
doaj +1 more source
Towards a Functional Cure of HIV-1: Insight Into the Chromatin Landscape of the Provirus
Frontiers in Microbiology, 2021 Despite potent combination antiretroviral therapy, HIV-1 infection persists due to irreversible integration of the virus in long-living cells of the immune system.
Julie Janssens +3 more
doaj +1 more source
Theoretical and Applied Mechanics Letters, 2020 : The construction of mechanical-mathematical model and numerical method for the deformation processes of rock massifs with goafs and underground structures is very complex and also important task in modern rock mechanics.
Michael Zhuravkov +2 more
doaj +1 more source
Experimental Investigation on the Torsion-Shear Behaviour at the Interfaces of Interlocking Masonry Block Assemblages [PDF]
, 2021 This paper presents an experimental investigation on the initial shear (cohesion) and torsion-shear strengths at the interface of an interlocking masonry block. An interlocking block is a rigid unit with locks avoiding the block to slide.
C. Ceraldi +11 more
core +1 more source
CounterAKTing HIV: Toward a “Block and Clear” Strategy?
Frontiers in Cellular and Infection Microbiology, 2022 The protein kinase B or Akt is a central regulator of survival, metabolism, growth and proliferation of the cells and is known to be targeted by various viral pathogens, including HIV-1.
Sébastien Pasquereau +2 more
doaj +1 more source
Lock out: targeting TMPRSS2 to block influenza and coronaviruses
Journal of VirologyCoronaviruses and influenza A viruses (IAV) can cause severe respiratory disease and have pandemic potential. Both viruses depend on priming of their glycoproteins by host cell proteases for the acquisition of infectivity, and the responsible enzymes ...
Lu Zhang +2 more
doaj +1 more source
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source