Results 51 to 60 of about 34,722 (290)
Small RNA zippers lock miRNA molecules and block miRNA function in mammalian cells
Nature Communications, 2017 MicroRNAs regulate a wide range of biological processes and being able to inhibit their function could allow the development of therapeutic options.
Lingyu Meng +16 more
doaj +1 more source
Molecular Oncology, EarlyView.Extracellular vesicle (EV) lipidomic profiling of plasma and ascites from patients with high‐grade serous ovarian cancer and of ovarian cancer cell lines reveals enrichment of triglycerides (TGs), diacylglycerols (DGs), phosphatidylcholine (PCs), sphingomyelins (SMs), reflecting tumor metabolic reprogramming.
Shikha Rani +9 more
wiley +1 more source
Analysis on Locking Mechanism Performance of SCM Running Tool for Subsea Horizontal X-tree
Shiyou jixie, 2016 The locking element is the most significant part of the whole SCMRT.In the theoretical analysis,locking angle,unlocking angle and cone angle are mainly considered for the lock block.Self-locking would not occur when the lock angle α is larger than 8.5 ...
Zhang Kailong +4 more
doaj
Orthopaedic Journal of Sports Medicine, 2021 Objectives: The initial clinical presentation of the discoid lateral meniscus (DLM) in children is highly variable and can be difficult to assess.
Simon Vandergugten MD +4 more
doaj +1 more source
Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation
Molecular Oncology, EarlyView.How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim +11 more
wiley +1 more source
Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes
FEBS Open Bio, EarlyView.Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard +12 more
wiley +1 more source
Fine-grained multiprocessor real-time locking with improved blocking [PDF]
Proceedings of the 21st International conference on Real-Time Networks and Systems, 2013 Existing multiprocessor real-time locking protocols that support nesting are subject to adverse blocking that can be avoided when additional resource-usage-pattern information is known. These sources of blocking stem from system overheads, varying critical section lengths, and a lack of support for replicated resources.
Bryan C. Ward, James H. Anderson
openaire +1 more source
MagmaFlow: A desktop platform for artificial intelligence‐driven expression analysis
FEBS Open Bio, EarlyView.MagmaFlow is a free, no‐code platform for gene expression analysis. It generates interactive volcano plots, links genes to literature, pathways, and diseases, prioritizes candidates using millions of publications, identifies affected biological processes, builds network diagrams, and exports publication‐ready figures and reports for macOS and Windows ...
Carlos E. Buss +7 more
wiley +1 more source
On the Security of Time-Lock Puzzles and Timed Commitments [PDF]
, 2020 Time-lock puzzles---problems whose solution requires some amount of sequential effort---have recently received increased interest (e.g., in the context of verifiable delay functions).
Jonathan Katz, Julian Loss, Jiayu Xu
core +2 more sources
Fault locking, block rotation and crustal deformation in the Pacific Northwest [PDF]
Geophysical Journal International, 2007 SummaryWe interpret Global Positioning System (GPS) measurements in the northwestern United States and adjacent parts of western Canada to describe relative motions of crustal blocks, locking on faults and permanent deformation associated with convergence between the Juan de Fuca and North American plates.
McCaffrey, R. +8 more
openaire +2 more sources