Results 11 to 20 of about 32,738 (234)
Shock and kill within the CNS: A promising HIV eradication approach? [PDF]
Journal of Leukocyte Biology, 2022 AbstractThe most studied HIV eradication approach is the “shock and kill” strategy, which aims to reactivate the latent reservoir by latency reversing agents (LRAs) and allowing elimination of these cells by immune-mediated clearance or viral cytopathic effects. The CNS is an anatomic compartment in which (persistent) HIV plays an important role in HIV-
Jori Symons +2 more
exaly +7 more sources
Getting the “Kill” into “Shock and Kill”: Strategies to Eliminate Latent HIV [PDF]
Cell Host and Microbe, 2018 Despite the success of antiretroviral therapy (ART), there is currently no HIV cure and treatment is life long. HIV persists during ART due to long-lived and proliferating latently infected CD4+ T cells. One strategy to eliminate latency is to activate virus production using latency reversing agents (LRAs) with the goal of triggering cell death through
Sharon R. Lewin +2 more
exaly +6 more sources
Development of cytotoxic enhancing agents (CEAs) to improve shock-and-kill strategies
Journal of Virus Eradication, 2019 R Brad Jones, A Bosque, S -H Huang
exaly +4 more sources
Early lessons from shock and kill trials
Journal of Virus Eradication, 2017 O.S. Søgaard
doaj +2 more sources
World free HIV: the novel therapeutic approaches for eliminating latent HIV infection [PDF]
Virology JournalAntiretroviral therapy (ART) is an intervention aimed at preventing the development and spread of HIV. The persistence of proviruses in the CD4 + memory T cells, which are transcriptionally inactive and other drug-resistant reservoirs, makes treatment of
Akmal Zubair +4 more
doaj +2 more sources
CounterAKTing HIV: Toward a “Block and Clear” Strategy?
Frontiers in Cellular and Infection Microbiology, 2022 The protein kinase B or Akt is a central regulator of survival, metabolism, growth and proliferation of the cells and is known to be targeted by various viral pathogens, including HIV-1.
Sébastien Pasquereau +2 more
doaj +1 more source
Understanding Viral and Immune Interplay During Vertical Transmission of HIV: Implications for Cure
Frontiers in Immunology, 2021 Despite the significant progress that has been made to eliminate vertical HIV infection, more than 150,000 children were infected with HIV in 2019, emphasizing the continued need for sustainable HIV treatment strategies and ideally a cure for children ...
Omayma Amin +4 more
doaj +1 more source
mBio, 2022 Application of the combination antiretroviral therapy (cART) has reduced AIDS to a manageable chronic infectious disease. However, HIV/AIDS cannot be cured because of the presence of latent reservoirs, thus calling for the development of antiretroviral ...
Xinling Wang +9 more
doaj +1 more source
Natural killer cells induce HIV-1 latency reversal after treatment with pan-caspase inhibitors
Frontiers in Immunology, 2022 The establishment of a latency reservoir is the major obstacle for a cure of HIV-1. The shock-and-kill strategy aims to reactivate HIV-1 replication in HIV -1 latently infected cells, exposing the HIV-1-infected cells to cytotoxic lymphocytes.
Joana Furtado Milão +7 more
doaj +1 more source
Launching a multidisciplinary European collaboration towards a cure for HIV: The EU2Cure Consortium
Journal of Virus Eradication, 2021 We felt the urgency to launch the EU2Cure Consortium to support research and find a cure for the human immunodeficiency virus (HIV) infection through intensified collaboration within Europe.
C. Rokx +16 more
doaj +1 more source