Results 1 to 10 of about 25,365 (244)
New Concepts in Therapeutic Manipulation of HIV-1 Transcription and Latency: Latency Reversal versus Latency Prevention [PDF]
Viruses, 2023 Antiretroviral therapy (ART) has dramatically improved the prognosis for people living with HIV-1, but a cure remains elusive. The largest barrier to a cure is the presence of a long-lived latent reservoir that persists within a heterogenous mix of cell ...
Catherine A. Lewis +2 more
doaj +4 more sources
The role of latency reversal in HIV cure strategies [PDF]
Journal of Medical Primatology, 2022 AbstractOne strategy to eliminate latently infected cells that persist in people with HIV on antiretroviral therapy is to activate virus transcription and virus production to induce virus or immune‐mediated cell death. This is called latency reversal.
Sharon Ruth Lewin
exaly +5 more sources
Latency Reversal 2.0: Giving the Immune System a Seat at the Table [PDF]
Current HIV/AIDS Reports, 2021 Abstract Purpose of Review For most people living with HIV (PLWH), treatment with effective antiretroviral therapy (ART) results in suppression of viremia below the limit of detection of clinical assays, immune reconstitution, reduced immune activation, avoidance of opportunistic infections, and progression to AIDS ...
Ann Chahroudi +2 more
exaly +5 more sources
NSC95397 Is a Novel HIV-1 Latency-Reversing Agent
Viruses, 2023 The latent viral reservoir represents one of the major barriers to curing HIV-1. Focus on the “kick and kill” (also called “shock and kill”) approach, in which virus expression is reactivated, and then cells producing virus are selectively depleted, has ...
Randilea Nichols Doyle +5 more
doaj +6 more sources
Cells, 2021 Eradication of latent human immunodeficiency virus (HIV) infection is a global health challenge. Reactivation of HIV latency and killing of virus-infected cells, the so-called “kick and kill” or “shock and kill” approaches, are a popular strategy for HIV
Sushant Khanal +4 more
doaj +3 more sources
HIV-1 Latency and Latency Reversal: Does Subtype Matter? [PDF]
Viruses, 2019 Cells that are latently infected with HIV-1 preclude an HIV-1 cure, as antiretroviral therapy does not target this latent population. HIV-1 is highly genetically diverse, with over 10 subtypes and numerous recombinant forms circulating worldwide. In spite of this vast diversity, much of our understanding of latency and latency reversal is largely based
Indra Sarabia +2 more
exaly +3 more sources
HIV cure trial mergers: Spotlighting the epigenetics of latency reversal [PDF]
EBioMedicine, 2022 Paul W. Denton
doaj +4 more sources
Leveraging Novel Integrated Single-Cell Analyses to Define HIV-1 Latency Reversal [PDF]
Viruses, 2021 While suppressive antiretroviral therapy can effectively limit HIV-1 replication and evolution, it leaves behind a residual pool of integrated viral genomes that persist in a state of reversible nonproductive infection, referred to as the HIV-1 reservoir.
Suhui Zhao, Athe Tsibris
doaj +2 more sources
Distinct roles of dopamine receptors in HIV latency reversal in a myeloid cell model [PDF]
Frontiers in ImmunologyBackgroundCurrently, studies on the interactions between neurotransmitters and immune cells that are targets of HIV are limited by a focus on single pathways at a time.
Liana V. Basova +8 more
doaj +2 more sources
Small Molecule Inhibitors of BAF; A Promising Family of Compounds in HIV-1 Latency Reversal
EBioMedicine, 2016 Persistence of latently infected cells in presence of Anti-Retroviral Therapy presents the main obstacle to HIV-1 eradication. Much effort is thus placed on identification of compounds capable of HIV-1 latency reversal in order to render infected cells ...
Mateusz Stoszko +10 more
doaj +3 more sources