New Concepts in Therapeutic Manipulation of HIV-1 Transcription and Latency: Latency Reversal versus Latency Prevention [PDF]
Viruses, 2023 Antiretroviral therapy (ART) has dramatically improved the prognosis for people living with HIV-1, but a cure remains elusive. The largest barrier to a cure is the presence of a long-lived latent reservoir that persists within a heterogenous mix of cell ...
Catherine A. Lewis +2 more
doaj +2 more sources
PKC inhibitors reveal PKC isoforms involved in HIV latency reversal and immunomodulation [PDF]
Journal of VirologyThe reservoir of persistently latently infected cells is a major barrier to a cure for HIV infection. Protein kinase C (PKC) modulators can reverse HIV latency and could thus be useful “Kick” components in “Kick and Kill” approaches to a cure.
Thomas D. Zaikos +10 more
doaj +2 more sources
Cells, 2021 Eradication of latent human immunodeficiency virus (HIV) infection is a global health challenge. Reactivation of HIV latency and killing of virus-infected cells, the so-called “kick and kill” or “shock and kill” approaches, are a popular strategy for HIV
Sushant Khanal +4 more
doaj +3 more sources
Pharmacological METTL3 inhibition attenuates HIV-1 latency reversal in CD4+ T cells [PDF]
Antimicrobial Agents and ChemotherapyN6-methyladenosine (m6A) is a major epitranscriptomic modification that regulates RNA metabolism and affects the replication and latency reversal of human immunodeficiency virus type 1 (HIV-1) in cells.
Tarun Mishra, Avary Edwards, Li Wu
doaj +2 more sources
Distinct roles of dopamine receptors in HIV latency reversal in a myeloid cell model [PDF]
Frontiers in ImmunologyBackgroundCurrently, studies on the interactions between neurotransmitters and immune cells that are targets of HIV are limited by a focus on single pathways at a time.
Liana V. Basova +8 more
doaj +2 more sources
Small Molecule Inhibitors of BAF; A Promising Family of Compounds in HIV-1 Latency Reversal
EBioMedicine, 2016 Persistence of latently infected cells in presence of Anti-Retroviral Therapy presents the main obstacle to HIV-1 eradication. Much effort is thus placed on identification of compounds capable of HIV-1 latency reversal in order to render infected cells ...
Mateusz Stoszko +10 more
doaj +3 more sources
HIV-1 latency reversal agent boosting is not limited by opioid use [PDF]
JCI InsightOpioid use may affect the HIV-1 reservoir and its reversal from latency. We studied 47 virally suppressed people with HIV (PWH) and observed that lower concentration of HIV-1 latency reversal agents (LRAs), used with small molecules that did not reverse ...
Tyler Lilie +11 more
doaj +2 more sources
Release of P-TEFb from the Super Elongation Complex promotes HIV-1 latency reversal. [PDF]
PLoS PathogensThe persistence of HIV-1 in long-lived latent reservoirs during suppressive antiretroviral therapy (ART) remains one of the principal barriers to a functional cure. Blocks to transcriptional elongation play a central role in maintaining the latent state,
William J Cisneros +11 more
doaj +2 more sources
The role of latency reversal in HIV cure strategies [PDF]
Journal of Medical Primatology, 2022 Michael Roche +2 more
exaly +2 more sources
Isoform-Selective Versus Nonselective Histone Deacetylase Inhibitors in HIV Latency Reversal [PDF]
AIDS Research and Human Retroviruses, 2022 George B Kyei, Anthony Twumasi Boateng
exaly +2 more sources