New Concepts in Therapeutic Manipulation of HIV-1 Transcription and Latency: Latency Reversal versus Latency Prevention [PDF]
Viruses, 2023 Antiretroviral therapy (ART) has dramatically improved the prognosis for people living with HIV-1, but a cure remains elusive. The largest barrier to a cure is the presence of a long-lived latent reservoir that persists within a heterogenous mix of cell ...
Catherine A. Lewis +2 more
doaj +2 more sources
Cells, 2021 Eradication of latent human immunodeficiency virus (HIV) infection is a global health challenge. Reactivation of HIV latency and killing of virus-infected cells, the so-called “kick and kill” or “shock and kill” approaches, are a popular strategy for HIV
Sushant Khanal +4 more
doaj +3 more sources
Leveraging Novel Integrated Single-Cell Analyses to Define HIV-1 Latency Reversal [PDF]
Viruses, 2021 While suppressive antiretroviral therapy can effectively limit HIV-1 replication and evolution, it leaves behind a residual pool of integrated viral genomes that persist in a state of reversible nonproductive infection, referred to as the HIV-1 reservoir.
Suhui Zhao, Athe Tsibris
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Distinct roles of dopamine receptors in HIV latency reversal in a myeloid cell model [PDF]
Frontiers in ImmunologyBackgroundCurrently, studies on the interactions between neurotransmitters and immune cells that are targets of HIV are limited by a focus on single pathways at a time.
Liana V. Basova +8 more
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Small Molecule Inhibitors of BAF; A Promising Family of Compounds in HIV-1 Latency Reversal
EBioMedicine, 2016 Persistence of latently infected cells in presence of Anti-Retroviral Therapy presents the main obstacle to HIV-1 eradication. Much effort is thus placed on identification of compounds capable of HIV-1 latency reversal in order to render infected cells ...
Mateusz Stoszko +10 more
doaj +3 more sources
Bioactive Compounds from Euphorbia usambarica Pax. with HIV-1 Latency Reversal Activity [PDF]
Pharmaceuticals, 2021 Euphorbia usambarica is a traditional medicine used for gynecologic, endocrine, and urogenital illnesses in East Africa; however, its constituents and bioactivities have not been investigated.
Yu-Chi Tsai +9 more
doaj +2 more sources
HIV-1 latency reversal agent boosting is not limited by opioid use [PDF]
JCI InsightOpioid use may affect the HIV-1 reservoir and its reversal from latency. We studied 47 virally suppressed people with HIV (PWH) and observed that lower concentration of HIV-1 latency reversal agents (LRAs), used with small molecules that did not reverse ...
Tyler Lilie +11 more
doaj +2 more sources
Release of P-TEFb from the Super Elongation Complex promotes HIV-1 latency reversal. [PDF]
PLoS PathogensThe persistence of HIV-1 in long-lived latent reservoirs during suppressive antiretroviral therapy (ART) remains one of the principal barriers to a functional cure. Blocks to transcriptional elongation play a central role in maintaining the latent state,
William J Cisneros +11 more
doaj +2 more sources
The role of latency reversal in HIV cure strategies [PDF]
Journal of Medical Primatology, 2022 Youry Kim +2 more
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Isoform-Selective Versus Nonselective Histone Deacetylase Inhibitors in HIV Latency Reversal [PDF]
AIDS Research and Human Retroviruses, 2022 Evelyn Yayra Bonney, George B Kyei
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