Results 31 to 40 of about 388,981 (242)

Targeted HIV-1 Latency Reversal Using CRISPR/Cas9-Derived Transcriptional Activator Systems. [PDF]

PLoS ONE, 2016
CRISPR/Cas9 technology is currently considered the most advanced tool for targeted genome engineering. Its sequence-dependent specificity has been explored for locus-directed transcriptional modulation.
Julia K Bialek, Gábor A Dunay, Maike Voges, Carola Schäfer, Michael Spohn, Rolf Stucka, Joachim Hauber, Ulrike C Lange   +7 more
doaj   +1 more source

Crotonylation sensitizes IAPi-induced disruption of latent HIV by enhancing p100 cleavage into p52

iScience, 2022
Summary: The eradication of HIV infection is difficult to achieve because of stable viral reservoirs. Here, we show that crotonylation enhances AZD5582-induced noncanonical NF-κB (ncNF-κB) signaling, further augmenting HIV latency reversal in Jurkat and ...
Dajiang Li, Morgan G. Dewey, Li Wang, Shane D. Falcinelli, Lilly M. Wong, Yuyang Tang, Edward P. Browne, Xian Chen, Nancie M. Archin, David M. Margolis, Guochun Jiang   +10 more
doaj   +1 more source

The role of Tat in HIV latency and reactivation

Frontiers in Immunology
HIV persists during therapy due the existence of a latently infected reservoir in which viral gene expression is silenced. This reservoir thus represents the primary barrier to a cure for HIV.
David M. Margolis, Edward P. Browne
doaj   +1 more source

Polyanionic carbosilane dendrimers as a new adjuvant in combination with latency reversal agents for HIV treatment

Journal of Nanobiotechnology, 2019
Background The major obstacle impeding human immunodeficiency virus-1 (HIV-1) eradication in antiretroviral treatment (ART) treated HIV-1 subjects is the establishment of long-lived latently infected resting CD4+ T cells. Due to the fact that no drug has
Ignacio Relaño-Rodríguez, Raquel Juárez-Sánchez, Carolina Pavicic, Eduardo Muñoz, Maria Ángeles Muñoz-Fernández   +4 more
doaj   +1 more source

A Low-Latency Routing Protocol for Wireless Sensor Networks [PDF]

, 2013
Advanced Industrial Conference on Wireless Technologies (ICW 2005), August 14-17, 2005, Montreal, CanadaRecent advances in wireless sensors network (WSN) technology have made possible the manufacturing of tiny low-cost, low-power sensors with wireless ...
R. Tynan, Ruzzelli, Antonio G., O'Hare, G. M. P. (Greg M. P.), Tynan, Richard, G.M.P. O'Hare, O\u27Hare, G. M. P. (Greg M. P.), A.G. Ruzzelli   +6 more
core   +1 more source

Human Immunodeficiency Virus-1 Latency Reversal via the Induction of Early Growth Response Protein 1 to Bypass Protein Kinase C Agonist-Associated Immune Activation

Frontiers in Microbiology, 2022
Human Immunodeficiency Virus-1 (HIV) remains a global health challenge due to the latent HIV reservoirs in people living with HIV (PLWH). Dormant yet replication competent HIV harbored in the resting CD4+ T cells cannot be purged by antiretroviral ...
Lilly M. Wong, Dajiang Li, Yuyang Tang, Gema Méndez-Lagares, George R. Thompson, Dennis J. Hartigan-O’Connor, Satya Dandekar, Guochun Jiang, Guochun Jiang   +8 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Minimising latency of pitch detection algorithms for live vocals on low-cost hardware [PDF]

, 2016
A pitch estimation device was proposed for live vocals to output appropriate pitch data through the musical instrument digital interface (MIDI). The intention was to ideally achieve unnoticeable latency while maintaining estimation accuracy.
Firth, Matthew
core   +2 more sources

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Neutralization of the PTX3/CD44 axis suppresses TGF‐β1 signaling in kidney fibrosis

FEBS Letters, EarlyView.
This study investigates how the PTX3/CD44 axis promotes kidney fibrosis by activating TGF‐β1 signaling. We demonstrate that the neutralizing antibody WHC‐001 effectively inhibits this pathway, suppressing myofibroblast activation and partial epithelial–mesenchymal transition (EMT).
Chao‐Chun Cheng, Shen‐Shin Chang, Feng‐Wei Chen, Ying‐Chieh Su, Thanh Phuong Nguyen, Yu‐Wei Hsiao, Jhih‐Ying Chi, Hsin‐Yin Liang, Ju‐Ming Wang   +8 more
wiley   +1 more source