Trade-off between synergy and efficacy in combinations of HIV-1 latency-reversing agents. [PDF]
PLoS Computational Biology, 2018 Eradicating HIV-1 infection is difficult because of the reservoir of latently infected cells that gets established soon after infection, remains hidden from antiretroviral drugs and host immune responses, and retains the capacity to reignite infection ...
Vipul Gupta, Narendra M Dixit
doaj +1 more source
Latency reversal plus natural killer cells diminish HIV reservoir in vivo. [PDF]
Nat Commun, 2022 HIV is difficult to eradicate due to the persistence of a long-lived reservoir of latently infected cells. Previous studies have shown that natural killer cells are important to inhibiting HIV infection, but it is unclear whether the administration of ...
Kim JT +22 more
europepmc +2 more sources
Position effects influence HIV latency reversal [PDF]
Nature Structural & Molecular Biology, 2016 The main obstacle to curing HIV is the presence of latent proviruses in the bodies of infected patients. The partial success of reactivation therapies suggests that the genomic context of integrated proviruses can interfere with treatment. Here we developed a method called Barcoded HIV ensembles (B-HIVE) to map the chromosomal locations of thousands of
Heng-Chang Chen +4 more
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Combination Immune Checkpoint Blockade to Reverse HIV Latency [PDF]
The Journal of Immunology, 2020 Abstract In people living with HIV on antiretroviral therapy, HIV latency is the major barrier to a cure. HIV persists preferentially in CD4+ T cells expressing multiple immune checkpoint (IC) molecules, including programmed death (PD)-1, T cell Ig and mucin domain-containing protein 3 (TIM-3), lymphocyte associated gene 3 (LAG-3), and T
Renée M Van der Sluis +11 more
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A Two-Color Haploid Genetic Screen Identifies Novel Host Factors Involved in HIV-1 Latency
mBio, 2021 To identify novel host factors as putative targets to reverse HIV-1 latency, we performed an insertional mutagenesis genetic screen in a latent HIV-1 infected pseudohaploid KBM7 cell line (Hap-Lat).
Michael Röling +13 more
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Nanoparticle delivery of Tat synergizes with classical latency reversal agents to express HIV antigen targets [PDF]
Antimicrobial Agents and ChemotherapyEllen Van Gulck +2 more
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Proviral Latency, Persistent Human Immunodeficiency Virus Infection, and the Development of Latency Reversing Agents [PDF]
The Journal of Infectious Diseases, 2017 Quiescent proviral genomes that persist during human immunodeficiency virus type 1 (HIV-1) infection despite effective antiretroviral therapy (ART) can fuel rebound viremia after ART interruption and is a central obstacle to the cure of HIV infection.
David M, Margolis, Nancie M, Archin
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Defining stable reference genes in HIV latency reversal experiments. [PDF]
J Virol, 2021 Latency-reversing agents (LRAs) are ubiquitously used in the “shock-and-kill” HIV cure strategy, and their performance is often evaluated by ex vivo quantification of cell-associated HIV RNA. HIV RNA, measured by quantitative PCR (qPCR), is often normalized to internal reference genes, but the expression of these ...
Ceriani C +8 more
europepmc +4 more sources
The Current Status of Latency Reversing Agents for HIV-1 Remission [PDF]
Annual Review of Virology, 2021 Combinatory antiretroviral therapy (cART) reduces human immunodeficiency virus type 1 (HIV-1) replication but is not curative because cART interruption almost invariably leads to a rapid rebound of viremia due to the persistence of stable HIV-1-infected cellular reservoirs.
Rodari, Anthony +2 more
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Sensing of HIV-1 by TLR8 activates human T cells and reverses latency
Nature Communications, 2020 Manipulation of Toll-like receptors (TLRs) affects HIV-1 infection and latency reversal. Here, the authors show that HIV-1 is endocytosed and recognized by TLR8 in human primary CD4+T cells and that TLR8 stimulation induces an inflammatory response that ...
Hany Zekaria Meås +11 more
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