Results 31 to 40 of about 25,365 (244)

Sensing of HIV-1 by TLR8 activates human T cells and reverses latency

Nature Communications, 2020
Manipulation of Toll-like receptors (TLRs) affects HIV-1 infection and latency reversal. Here, the authors show that HIV-1 is endocytosed and recognized by TLR8 in human primary CD4+T cells and that TLR8 stimulation induces an inflammatory response that ...
Hany Zekaria Meås, Markus Haug, Marianne Sandvold Beckwith, Claire Louet, Liv Ryan, Zhenyi Hu, Johannes Landskron, Svein Arne Nordbø, Kjetil Taskén, Hang Yin, Jan Kristian Damås, Trude Helen Flo   +11 more
doaj   +1 more source

Proviral Latency, Persistent Human Immunodeficiency Virus Infection, and the Development of Latency Reversing Agents [PDF]

The Journal of Infectious Diseases, 2017
Quiescent proviral genomes that persist during human immunodeficiency virus type 1 (HIV-1) infection despite effective antiretroviral therapy (ART) can fuel rebound viremia after ART interruption and is a central obstacle to the cure of HIV infection.
David M, Margolis, Nancie M, Archin
openaire   +2 more sources

Latency reversal and viral clearance to cure HIV-1 [PDF]

Science, 2016
Next steps toward curing HIV-1 Since the discovery of HIV-1 more than 30 years ago, prevention and treatment strategies have dominated the research agenda. More recently, however, scientists are also focusing their efforts toward finding a cure. Margolis et al.
David M, Margolis, J Victor, Garcia, Daria J, Hazuda, Barton F, Haynes   +3 more
openaire   +2 more sources

The Current Status of Latency Reversing Agents for HIV-1 Remission [PDF]

Annual Review of Virology, 2021
Combinatory antiretroviral therapy (cART) reduces human immunodeficiency virus type 1 (HIV-1) replication but is not curative because cART interruption almost invariably leads to a rapid rebound of viremia due to the persistence of stable HIV-1-infected cellular reservoirs.
Rodari, Anthony, Darcis, Gilles, Van Lint, Carine   +2 more
openaire   +3 more sources

Combined noncanonical NF-κB agonism and targeted BET bromodomain inhibition reverse HIV latency ex vivo

The Journal of Clinical Investigation, 2022
Latency reversal strategies for HIV cure using inhibitor of apoptosis protein (IAP) antagonists (IAPi) induce unprecedented levels of latent reservoir expression without immunotoxicity during suppressive antiretroviral therapy (ART).
Shane D. Falcinelli, Jackson J. Peterson, Anne-Marie W. Turner, David Irlbeck, Jenna Read, Samuel L.M. Raines, Katherine S. James, Cameron Sutton, Anthony Sanchez, Ann Emery, Gavin Sampey, Robert Ferris, Brigitte Allard, Simon Ghofrani, Jennifer L. Kirchherr, Caroline Baker, JoAnn D. Kuruc, Cynthia L. Gay, Lindsey I. James, Guoxin Wu, Paul Zuck, Inmaculada Rioja, Rebecca C. Furze, Rab K. Prinjha, Bonnie J. Howell, Ronald Swanstrom, Edward P. Browne, Brian D. Strahl, Richard M. Dunham, Nancie M. Archin, David M. Margolis   +30 more
doaj   +1 more source

Humanized Mice for the Evaluation of Novel HIV-1 Therapies

Frontiers in Immunology, 2021
With the discovery of antiretroviral therapy, HIV-1 infection has transitioned into a manageable but chronic illness, which requires lifelong treatment. Nevertheless, complete eradication of the virus has still eluded us.
Shawn Abeynaike, Shawn Abeynaike, Silke Paust, Silke Paust   +3 more
doaj   +1 more source

HIV latency is reversed by ACSS2-driven histone crotonylation [PDF]

Journal of Clinical Investigation, 2018
Eradication of HIV-1 (HIV) is hindered by stable viral reservoirs. Viral latency is epigenetically regulated. While the effects of histone acetylation and methylation at the HIV long-terminal repeat (LTR) have been described, our knowledge of the proviral epigenetic landscape is incomplete.
Guochun Jiang, Don Nguyen, Nancie M. Archin, Steven A. Yukl, Gema Méndez-Lagares, Yuyang Tang, Maher M. Elsheikh, George R. Thompson, Dennis J. Hartigan-O’Connor, David M. Margolis, Joseph K. Wong, Satya Dandekar   +11 more
openaire   +4 more sources

Impact of latency‐reversing agents on human macrophage physiology

Immunity, Inflammation and Disease, 2022
AbstractIntroductionHIV‐1 eradication is hindered by the presence of inducible long‐lived reservoirs of latently infected cells which rapidly disseminate viral particles upon treatment interruption. Eliminating these reservoirs by the so‐called shock and kill strategy represents a crucial concept toward an HIV‐1 cure.
Laurent Hany, Marc‐Olivier Turmel, Corinne Barat, Michel Ouellet, Michel J. Tremblay   +4 more
openaire   +3 more sources

Latency reversal agents modulate HIV antigen processing and presentation to CD8 T cells.

PLoS Pathogens, 2020
Latency reversal agents (LRA) variably induce HIV re-expression in CD4 T cells but reservoirs are not cleared. Whether HIV epitope presentation is similar between latency reversal and initial infection of CD4 T cells is unknown yet crucial to define ...
Julie Boucau, Jishnu Das, Neelambari Joshi, Sylvie Le Gall   +3 more
doaj   +1 more source

Using repeatability of performance within and across contexts to validate measures of behavioral flexibility [PDF]

PeerJ, 2023
Research into animal cognitive abilities is increasing quickly and often uses methods where behavioral performance on a task is assumed to represent variation in the underlying cognitive trait.
Kelsey McCune, Aaron Blaisdell, Zoe Johnson-Ulrich, August Sevchik, Dieter Lukas, Maggie MacPherson, Benjamin Seitz, Corina J. Logan   +7 more
doaj   +2 more sources