Results 11 to 20 of about 26,399 (169)
Secreted factors induced by PKC modulators do not indirectly cause HIV latency reversal [PDF]
Virology, 2023 HIV can establish a long-lived latent infection in cells harboring integrated non-expressing proviruses. Latency reversing agents (LRAs), including protein kinase C (PKC) modulators, can induce expression of latent HIV, thereby reducing the latent ...
Alok Ranjan +2 more
exaly +4 more sources
HIV cure trial mergers: Spotlighting the epigenetics of latency reversal [PDF]
EBioMedicine, 2022 Paul W. Denton
doaj +4 more sources
Latency Reversal 2.0: Giving the Immune System a Seat at the Table [PDF]
Current HIV/AIDS Reports, 2021 Abstract Purpose of Review For most people living with HIV (PLWH), treatment with effective antiretroviral therapy (ART) results in suppression of viremia below the limit of detection of clinical assays, immune reconstitution, reduced immune activation, avoidance of opportunistic infections, and progression to AIDS ...
Amir Dashti +2 more
exaly +5 more sources
NSC95397 Is a Novel HIV-1 Latency-Reversing Agent
Viruses, 2023 The latent viral reservoir represents one of the major barriers to curing HIV-1. Focus on the “kick and kill” (also called “shock and kill”) approach, in which virus expression is reactivated, and then cells producing virus are selectively depleted, has ...
Randilea Nichols Doyle +5 more
doaj +6 more sources
Latency reversal agents modulate HIV antigen processing and presentation to CD8 T cells.
PLoS Pathogens, 2020 Latency reversal agents (LRA) variably induce HIV re-expression in CD4 T cells but reservoirs are not cleared. Whether HIV epitope presentation is similar between latency reversal and initial infection of CD4 T cells is unknown yet crucial to define ...
Julie Boucau +3 more
doaj +2 more sources
Diverse effects of interferon alpha on the establishment and reversal of HIV latency [PDF]
PLOS Pathogens, 2020 HIV latency is the major barrier to a cure for people living with HIV (PLWH) on antiretroviral therapy (ART) because the virus persists in long-lived non-proliferating and proliferating latently infected CD4+ T cells. Latently infected CD4+ T cells do not express viral proteins and are therefore not visible to immune mediated clearance.
Renée M. Van der Sluis +16 more
core +9 more sources
Latency reversal and viral clearance to cure HIV-1 [PDF]
Science, 2016 Next steps toward curing HIV-1 Since the discovery of HIV-1 more than 30 years ago, prevention and treatment strategies have dominated the research agenda. More recently, however, scientists are also focusing their efforts toward finding a cure. Margolis et al.
David M, Margolis +3 more
openaire +4 more sources
The role of Tat in HIV latency and reactivation [PDF]
Frontiers in ImmunologyHIV persists during therapy due the existence of a latently infected reservoir in which viral gene expression is silenced. This reservoir thus represents the primary barrier to a cure for HIV.
David M. Margolis, Edward P. Browne
doaj +4 more sources
Long non-coding RNAs and latent HIV - A search for novel targets for latency reversal.
PLoS ONE, 2019 The latent cellular reservoir of HIV is recognized as the major barrier to cure from HIV infection. Long non-coding RNAs (lncRNAs) are more tissue and cell type-specific than protein coding genes, and may represent targets of choice for HIV latency ...
Wim Trypsteen +10 more
doaj +2 more sources
Reversed short-latency ocular following
Vision Research, 2002 Using the scleral search coil technique to monitor eye movements, we recorded short-latency ocular following responses to displacement steps of large random-dot patterns. On half of the trials, the luminance of the dots and background were reversed during the step, a procedure that is known to reverse the direction of the perceived motion ("reverse phi"
Masson, Guillaume, Yang, D-S, Miles, F.A
openaire +4 more sources