Results 11 to 20 of about 388,981 (242)
Bioactive Compounds from Euphorbia usambarica Pax. with HIV-1 Latency Reversal Activity
Pharmaceuticals, 2021 Euphorbia usambarica is a traditional medicine used for gynecologic, endocrine, and urogenital illnesses in East Africa; however, its constituents and bioactivities have not been investigated.
Yu-Chi Tsai +9 more
doaj +2 more sources
HIV cure trial mergers: Spotlighting the epigenetics of latency reversal [PDF]
EBioMedicine, 2022 Paul W. Denton
doaj +2 more sources
Viruses, 2023 We sought to explore the hypothesis that host factors required for HIV-1 replication also play a role in latency reversal. Using a CRISPR gene library of putative HIV dependency factors, we performed a screen to identify genes required for latency ...
Terry L. Hafer +4 more
doaj +1 more source
Biomolecules, 2023 The “block and lock” strategy is one approach that might elicit a sterilizing cure for HIV-1 infection. The “block” refers to a compound’s ability to inhibit latent HIV-1 proviral transcription, while the “lock” refers to its capacity to induce permanent
Benni Vargas +3 more
doaj +1 more source
Secreted factors induced by PKC modulators do not indirectly cause HIV latency reversal. [PDF]
Virology, 2023 HIV can establish a long-lived latent infection in cells harboring integrated non-expressing proviruses. Latency reversing agents (LRAs), including protein kinase C (PKC) modulators, can induce expression of latent HIV, thereby reducing the latent ...
Moran JA +6 more
europepmc +2 more sources
Trade-off between synergy and efficacy in combinations of HIV-1 latency-reversing agents. [PDF]
PLoS Computational Biology, 2018 Eradicating HIV-1 infection is difficult because of the reservoir of latently infected cells that gets established soon after infection, remains hidden from antiretroviral drugs and host immune responses, and retains the capacity to reignite infection ...
Vipul Gupta, Narendra M Dixit
doaj +1 more source
Leveraging Novel Integrated Single-Cell Analyses to Define HIV-1 Latency Reversal
Viruses, 2021 While suppressive antiretroviral therapy can effectively limit HIV-1 replication and evolution, it leaves behind a residual pool of integrated viral genomes that persist in a state of reversible nonproductive infection, referred to as the HIV-1 reservoir.
Suhui Zhao, Athe Tsibris
doaj +1 more source
A Two-Color Haploid Genetic Screen Identifies Novel Host Factors Involved in HIV-1 Latency
mBio, 2021 To identify novel host factors as putative targets to reverse HIV-1 latency, we performed an insertional mutagenesis genetic screen in a latent HIV-1 infected pseudohaploid KBM7 cell line (Hap-Lat).
Michael Röling +13 more
doaj +1 more source
Two Views on Time Reversal [PDF]
, 2008 In a recent paper, Malament (2004) employs a time reversal transformation that differs from the standard one, without explicitly arguing for it. This is a new and important understanding of time reversal that deserves arguing for in its own right.
Jill North, North, Jill
core +1 more source
Reducing latency when using Virtual Reality for teaching in sport [PDF]
, 2008 Latency is a frequently cited shortcoming of Virtual Reality (VR) applications. To compensate for excessive latency, prediction mechanisms may use sophisticated mathematical algorithms, which may not be appropriate for complex virtual teaching ...
Gilbert, Lester +2 more
core +2 more sources