Results 11 to 20 of about 25,365 (244)
Bioactive Compounds from Euphorbia usambarica Pax. with HIV-1 Latency Reversal Activity [PDF]
Pharmaceuticals, 2021 Euphorbia usambarica is a traditional medicine used for gynecologic, endocrine, and urogenital illnesses in East Africa; however, its constituents and bioactivities have not been investigated.
Yu-Chi Tsai +9 more
doaj +2 more sources
Novel Latency Reversal Agents for HIV-1 Cure [PDF]
Annual Review of Medicine, 2018 Antiretroviral therapy (ART) has rendered HIV-1 infection a treatable illness; however, ART is not curative owing to the persistence of replication-competent, latent proviruses in long-lived resting T cells. Strategies that target these latently infected cells and allow immune recognition and clearance of this reservoir will be necessary to eradicate ...
Vicente Planelles, Adam Spivak
exaly +3 more sources
HIV-1 latency reversal agent boosting is not limited by opioid use [PDF]
JCI InsightOpioid use may affect the HIV-1 reservoir and its reversal from latency. We studied 47 virally suppressed people with HIV (PWH) and observed that lower concentration of HIV-1 latency reversal agents (LRAs), used with small molecules that did not reverse ...
Tyler Lilie +11 more
doaj +2 more sources
Defining stable reference genes in HIV latency reversal experiments. [PDF]
J Virol, 2021 Latency-reversing agents (LRAs) are ubiquitously used in the “shock-and-kill” HIV cure strategy, and their performance is often evaluated by ex vivo quantification of cell-associated HIV RNA. HIV RNA, measured by quantitative PCR (qPCR), is often normalized to internal reference genes, but the expression of these ...
Ceriani C +8 more
europepmc +4 more sources
Latency Reversing Agents and the Road to an HIV Cure
PathogensHIV-1 infection cannot be cured due to the presence of HIV-1 latently infected cells. These cells do not produce the virus, but they can resume virus production at any time in the absence of antiretroviral therapy. Therefore, people living with HIV (PLWH)
Louis Tioka +3 more
doaj +4 more sources
Release of P-TEFb from the Super Elongation Complex promotes HIV-1 latency reversal. [PDF]
PLoS PathogensThe persistence of HIV-1 in long-lived latent reservoirs during suppressive antiretroviral therapy (ART) remains one of the principal barriers to a functional cure. Blocks to transcriptional elongation play a central role in maintaining the latent state,
William J Cisneros +11 more
doaj +2 more sources
Isoform-Selective Versus Nonselective Histone Deacetylase Inhibitors in HIV Latency Reversal [PDF]
AIDS Research and Human Retroviruses, 2022 Evelyn Yayra Bonney, George Kyei
exaly +2 more sources
Secreted factors induced by PKC modulators do not indirectly cause HIV latency reversal [PDF]
Virology, 2023 Jérôme Zack +2 more
exaly +2 more sources
Viruses, 2023 We sought to explore the hypothesis that host factors required for HIV-1 replication also play a role in latency reversal. Using a CRISPR gene library of putative HIV dependency factors, we performed a screen to identify genes required for latency ...
Terry L. Hafer +4 more
doaj +1 more source