Results 41 to 50 of about 26,399 (169)

HIV latency is reversed by ACSS2-driven histone crotonylation [PDF]

Journal of Clinical Investigation, 2018
Eradication of HIV-1 (HIV) is hindered by stable viral reservoirs. Viral latency is epigenetically regulated. While the effects of histone acetylation and methylation at the HIV long-terminal repeat (LTR) have been described, our knowledge of the proviral epigenetic landscape is incomplete.
Guochun Jiang, Don Nguyen, Nancie M. Archin, Steven A. Yukl, Gema Méndez-Lagares, Yuyang Tang, Maher M. Elsheikh, George R. Thompson, Dennis J. Hartigan-O’Connor, David M. Margolis, Joseph K. Wong, Satya Dandekar   +11 more
openaire   +4 more sources

HSF1 inhibition attenuates HIV-1 latency reversal mediated by several candidate LRAs In Vitro and Ex Vivo [PDF]

, 2020
HIV-1 latency is a major barrier to cure. Identification of small molecules that destabilize latency and allow immune clearance of infected cells could lead to treatment-free remission.
Beg, Subul, Siliciano, Janet D, Lai, Jun, Wu, Fengting, Siliciano, Robert F, Yukl, Steven A, Fray, Emily, Bullen, Cynthia Korin, Dai, Weiwei, Kumar, Mithra, Kim, Peggy, Yang, Chao, Pomerantz, Joel L, Hetzel, Carrie, Timmons, Andrew   +14 more
core   +1 more source

Combined noncanonical NF-κB agonism and targeted BET bromodomain inhibition reverse HIV latency ex vivo

The Journal of Clinical Investigation, 2022
Latency reversal strategies for HIV cure using inhibitor of apoptosis protein (IAP) antagonists (IAPi) induce unprecedented levels of latent reservoir expression without immunotoxicity during suppressive antiretroviral therapy (ART).
Shane D. Falcinelli, Jackson J. Peterson, Anne-Marie W. Turner, David Irlbeck, Jenna Read, Samuel L.M. Raines, Katherine S. James, Cameron Sutton, Anthony Sanchez, Ann Emery, Gavin Sampey, Robert Ferris, Brigitte Allard, Simon Ghofrani, Jennifer L. Kirchherr, Caroline Baker, JoAnn D. Kuruc, Cynthia L. Gay, Lindsey I. James, Guoxin Wu, Paul Zuck, Inmaculada Rioja, Rebecca C. Furze, Rab K. Prinjha, Bonnie J. Howell, Ronald Swanstrom, Edward P. Browne, Brian D. Strahl, Richard M. Dunham, Nancie M. Archin, David M. Margolis   +30 more
doaj   +1 more source

Impact of latency‐reversing agents on human macrophage physiology

Immunity, Inflammation and Disease, 2022
AbstractIntroductionHIV‐1 eradication is hindered by the presence of inducible long‐lived reservoirs of latently infected cells which rapidly disseminate viral particles upon treatment interruption. Eliminating these reservoirs by the so‐called shock and kill strategy represents a crucial concept toward an HIV‐1 cure.
Laurent Hany, Marc‐Olivier Turmel, Corinne Barat, Michel Ouellet, Michel J. Tremblay   +4 more
openaire   +3 more sources

Motion extrapolation in the central fovea [PDF]

, 2012
Neural transmission latency would introduce a spatial lag when an object moves across the visual field, if the latency was not compensated. A visual predictive mechanism has been proposed, which overcomes such spatial lag by extrapolating the position of
Nijhawan, Romi, Romi Nijhawan (177226), Shi, Zhuanghua, Nijhawan Romi, Romi Nijhawan, Zhuanghua Shi (177221), Shi Zhuanghua, Zhuanghua Shi   +7 more
core   +1 more source

Humanized Mice for the Evaluation of Novel HIV-1 Therapies

Frontiers in Immunology, 2021
With the discovery of antiretroviral therapy, HIV-1 infection has transitioned into a manageable but chronic illness, which requires lifelong treatment. Nevertheless, complete eradication of the virus has still eluded us.
Shawn Abeynaike, Shawn Abeynaike, Silke Paust, Silke Paust   +3 more
doaj   +1 more source

Development of a latency model for HIV-1 subtype C and the impact of long terminal repeat element genetic variation on latency reversal. [PDF]

J Virus Erad
Sub-Saharan Africa accounts for almost 70 % of people living with HIV (PLWH) worldwide, with the greatest numbers centred in South Africa where 98 % of infections are caused by subtype C (HIV-1C).
Maikoo S, Palstra RJ, Dong KL, Mahmoudi T, Ndung'u T, Madlala P.   +5 more
europepmc   +2 more sources

Small Molecule Targeting of Specific BAF (mSWI/SNF) Complexes for HIV Latency Reversal [PDF]

, 2018
The persistence of a pool of latently HIV-1-infected cells despite combination anti-retroviral therapy treatment is the major roadblock for a cure. The BAF (mammalian SWI/SNF) chromatin remodeling complex is involved in establishing and maintaining viral
Duvall, Jeremy R, Crabtree, GR, Marian, CA, Crignis, Elisa, Maschinot, Chad A, Carter, BC, Maschinot, CA, Wang, L, Carter, Benjamin C, Hargreaves, DC, Hargreaves, Diana C, Crabtree, Gerald R, Gatchalian, Jovylyn, Leighty, Matthew W, Dykhuizen, Emily C, Chowdhury, Basudev, Gatchalian, J, Dykhuizen, E C, Marian, Christine A, Chowdhury, B, Mahmoudi, Tokameh, Wang, Lili, Leighty, MW, Duvall, JR, de Crignis, Elisa, Stoszko, Mateusz   +25 more
core   +1 more source

Using repeatability of performance within and across contexts to validate measures of behavioral flexibility [PDF]

PeerJ, 2023
Research into animal cognitive abilities is increasing quickly and often uses methods where behavioral performance on a task is assumed to represent variation in the underlying cognitive trait.
Kelsey McCune, Aaron Blaisdell, Zoe Johnson-Ulrich, August Sevchik, Dieter Lukas, Maggie MacPherson, Benjamin Seitz, Corina J. Logan   +7 more
doaj   +2 more sources

Crotonylation sensitizes IAPi-induced disruption of latent HIV by enhancing p100 cleavage into p52

iScience, 2022
Summary: The eradication of HIV infection is difficult to achieve because of stable viral reservoirs. Here, we show that crotonylation enhances AZD5582-induced noncanonical NF-κB (ncNF-κB) signaling, further augmenting HIV latency reversal in Jurkat and ...
Dajiang Li, Morgan G. Dewey, Li Wang, Shane D. Falcinelli, Lilly M. Wong, Yuyang Tang, Edward P. Browne, Xian Chen, Nancie M. Archin, David M. Margolis, Guochun Jiang   +10 more
doaj   +1 more source