Results 61 to 70 of about 26,399 (169)
DISCOVERY OF NEW LATENCY REVERSAL TARGETS AND DEVELOPMENT OF ASSAYS TO MEASURE THE LATENT RESERVOIR
, 2021 Human Immunodeficiency Virus (HIV) infects human CD4+ T-cells and causes terminal disease if left untreated. Despite treatment with antiretroviral therapy, some infected cells that contain replication competent and transcriptionally silenced HIV persist.
Sanchez, Anthony
core +1 more source
eLife, 2018 Human immunodeficiency virus (HIV) infection is currently incurable, due to the persistence of latently infected cells. The ‘shock and kill’ approach to a cure proposes to eliminate this reservoir via transcriptional activation of latent proviruses ...
Emilie Battivelli +10 more
doaj +1 more source
Inhibitors of Signaling Pathways That Block Reversal of HIV-1 Latency [PDF]
Antimicrobial Agents and Chemotherapy, 2019 Signaling pathways play a key role in HIV-1 latency. In this study, we used the 24ST1NLESG cell line of HIV-1 latency to screen a library of structurally diverse, medicinally active, cell permeable kinase inhibitors, which target a wide range of signaling pathways, to identify inhibitors of HIV-1 latency reversal.
Benni, Vargas +6 more
openaire +2 more sources
STAR ProtocolsSummary: Investigating the molecular mechanisms of HIV latency reversal in a proper physiological context can only be done in primary cells. Here, we describe a primary T cell model of HIV latency and a reliable flow cytometry assay to measure latency ...
Uri Mbonye +3 more
doaj +1 more source
eLife, 2018 An improved dual-color reporter reveals how the fate of latent HIV-1 depends on where it integrates in the human genome.
Marina Lusic
doaj +1 more source
Reversal of HIV-1 latency with anti-microRNA inhibitors [PDF]
The International Journal of Biochemistry & Cell Biology, 2009 Human immunodeficiency virus type 1 (HIV-1) latency is achieved when host cells contain integrated proviral DNA but do not produce viral particles. The virus remains in resting CD4 T-lymphocytes, evading host immune surveillance and antiviral drugs. When resting cells are activated, infectious viral particles are produced.
openaire +2 more sources
FrameWorks 3D: composition in the third dimension
, 2009 Music composition on computer is a challenging task, involving a range of data types to be managed within a single software tool. A composition typically comprises a complex arrangement of material, with many internal relationships between data in ...
Richard Polfreman, Polfreman, Richard
core +1 more source
Enhancer H3K27ac modulates T-cell stimulation and HIV-1 latency reversal.
, 2020 (A) H3 modifications H3K27ac, H3K27me3 and H3K9me3 ChIP over the HIV-1 provirus. DNA and chromatin was isolated 48h after DMSO or PMA/i treatment of Bcl2-donor cells.
Birgitta Lindqvist (8378349) +4 more
core +1 more source
Dual TLR2 and TLR7 agonists as HIV latency-reversing agents [PDF]
JCI Insight, 2018 The presence of a reservoir of latently infected cells in HIV-infected patients is a major barrier towards finding a cure. One active cure strategy is to find latency-reversing agents that induce viral reactivation, thus leading to immune cell recognition and elimination of latently infected cells, known as the shock-and-kill strategy.
Amanda B. Macedo +10 more
openaire +2 more sources
Identification of Novel HIV-1 Latency-Reversing Agents from a Library of Marine Natural Products
Viruses, 2018 Natural products originating from marine and plant materials are a rich source of chemical diversity and unique antimicrobials. Using an established in vitro model of HIV-1 latency, we screened 257 pure compounds from a marine natural product library and
Khumoekae Richard +6 more
doaj +1 more source