Results 81 to 90 of about 26,399 (169)

Comparison of latency development in pattern and orientation reversal VEPs

, 2012
The latency of Pattern-Reversal (PR)-VEP was present at birth and the latency of its first positive peak has been found to develop rapidly, reaching the adult level around 15 weeks of age.
Jin Lee; Deirdre Birtles; John Wattam-Bell; Janette Atkinson; Oliver Braddick
core  

Curaxin CBL0137 has the potential to reverse HIV‐1 latency

Journal of Medical Virology, 2019
AbstractA cure for human immunodeficiency virus type‐1 (HIV‐1) has been hampered by the limitation of current combination antiretroviral therapy (cART) to address the latent reservoirs in HIV‐1 patients. One strategy proposed to eradicate these reservoirs is the “shock and kill” approach, where latency‐reversing agents (LRAs) are used to reactivate and
Maxime J. Jean, Dawei Zhou, Guillaume Fiches, Weili Kong, Huachao Huang, Andrei Purmal, Katerina Gurova, Netty G. Santoso, Jian Zhu   +8 more
openaire   +3 more sources

Effector memory differentiation increases detection of replication-competent HIV-l in resting CD4+ T cells from virally suppressed individuals.

PLoS Pathogens, 2019
Studies have demonstrated that intensive ART alone is not capable of eradicating HIV-1, as the virus rebounds within a few weeks upon treatment interruption.
Elizabeth R Wonderlich, Krupa Subramanian, Bryan Cox, Ann Wiegand, Carol Lackman-Smith, Michael J Bale, Mars Stone, Rebecca Hoh, Mary F Kearney, Frank Maldarelli, Steven G Deeks, Michael P Busch, Roger G Ptak, Deanna A Kulpa   +13 more
doaj   +1 more source

Antidepressant suppression of REM and spindle sleep impairs hippocampus-dependent learning and memory but fosters striatal-dependent strategies

, 2011
REM sleep enhances hippocampus-dependent associative memory but has little impact on striatal-dependent procedural learning. Antidepressant medications like desipramine (DMI) inhibit rapid-eye-movement (REM) sleep but it is little understood how ...
Jamie Sweigart, Alain Watts, Howard Gritton, Gina Poe   +3 more
core  

A Single-Cell Perspective on the Effects of Dopamine in the Regulation of HIV Latency Phenotypes in a Myeloid Cell Model

Viruses
Psychostimulants such as methamphetamine (Meth) induce high dopamine (DA) levels in the brain, which can modify immune cells expressing DA receptors. This is relevant in conditions of infection with the human immunodeficiency virus (HIV), overlapping ...
Liana V. Basova, Wei Ling Lim, Violaine Delorme-Walker, Tera Riley, Kaylin Au, Daniel Siqueira Lima, Marina Lusic, Ronald J. Ellis, Howard S. Fox, Maria Cecilia Garibaldi Marcondes   +9 more
doaj   +1 more source

HIV-1 has a sweet tooth: glucose metabolism drives the multistep process of HIV-1 latency reversal [PDF]

The major barrier to a cure for HIV-1 is the establishment of latency in long-lived CD4+ T cells within lymphoid tissues which readily fuel viral rebound upon antiretroviral therapy (ART) interruption.
Kayode, Yetunde
core  

INVESTIGATING HIV-1 LATENCY REVERSAL UPON COGNATE ANTIGEN RECOGNITION IN CD4+ T CELLS FROM PEOPLE ON ANTIRETROVIRAL THERAPY

, 2023
Despite the advancement in antiretroviral therapy (ART) which effectively prevents viral replication and transmission, there is no cure for Human Immunodeficiency Virus type 1 (HIV-1) infection.
Moskovljevic, Milica
core   +1 more source

Inconsistent Reversal of HIV-1 Latency Ex Vivo by Antigens of HIV-1, CMV, and Other Infectious Agents

, 2020
BackgroundA reservoir of replication-competent but latent virus is the main obstacle to a cure for HIV-infection. Much of this reservoir resides in memory CD4 T cells.
Guatelli, John C, Kumar, Nikesh M, Angerstein, Aaron O, Richman, Douglas D, Vollbrecht, Thomas, Oliveira, Michelli Faria, Menke, Bryson, de Oliveira, Michelli Faria   +7 more
core   +1 more source

Pattern-reversal visual evoked potentials in infants: gender differences during early visual maturation

, 2002
This paper investigates gender differences in the peak latency and amplitude of the P1 component of the pattern-reversal visual evoked potential (pattern-reversal VEP) recorded in healthy term infants.
Malcolm, CA, McCulloch, Daphne L, Shepherd, AJ, McCulloch, D. L., CA Malcolm, Malcolm, Cari, Shepherd, A. J., DL McCulloch, AJ Shepherd, McCulloch, DL, Malcolm, C. A.; id_orcid, Shepherd, Ashley   +11 more
core   +1 more source

Epitranscriptomic m6A modifications during reactivation of HIV-1 latency in CD4+ T cells

mBio
Despite effective antiretroviral therapy reducing HIV-1 viral loads to undetectable levels, the presence of latently infected CD4+ T cells poses a major barrier to HIV-1 cure.
Tarun Mishra, Stacia Phillips, Yutao Zhao, Bethany Wilms, Chuan He, Li Wu   +5 more
doaj   +1 more source