We studied whole transcriptome dynamics by RNA-sequencing in primary human cells from HIV-1+ individuals in response to in vitro exposure to the latency reversing agent bryostatin. Cells displayed an overt DNA damage-based primary response to bryostatin characterized by activation of CHEK1 and RAD54L. Cells induced the topoisomerase TOP2A together with
openaire +1 more source
HSV-2 triggers upregulation of MALAT1 in CD4+ T cells and promotes HIV latency reversal. [PDF]
J Clin Invest, 2023 Pierce CA +13 more
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IRF7 expression correlates with HIV latency reversal upon specific blockade of immune activation. [PDF]
Front Immunol, 2022 Ezeonwumelu IJ +13 more
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Targeting NF-κB signaling for HIV latency reversal: Mechanisms, challenges, and therapeutic perspectives. [PDF]
Virus ResShirazi MMA, Sadat SM.
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Virally Suppressed People Living with HIV Who Use Opioids Have Diminished Latency Reversal. [PDF]
Viruses, 2023 Basukala B +10 more
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Lithium attenuates HIV-1 latency reversal in an autophagy-independent way. [PDF]
iScienceAbdalla AL +5 more
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Ex vivo-expanded allogeneic Vδ2 T cells specifically reduce reservoirs of HIV-1 following latency reversal. [PDF]
JCI InsightMann BT +5 more
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Schlafen 12 restricts HIV-1 latency reversal by a codon-usage dependent post-transcriptional block in CD4+ T cells. [PDF]
Commun Biol, 2023 Kobayashi-Ishihara M +22 more
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Investigating the ubiquitin-proteasome system for targeted reversal of HIV-1 latency
, 2018 HIV is a worldwide epidemic, remaining the ever-present specter among all matters regarding blood or other bodily fluids, such as sexual intercourse, healthcare, blood transfusions, or even surgery, particularly in resource-poor areas.
core
Interleukin-2 is a potent latency reversal agent in people with treated HIV-1. [PDF]
Sci AdvFreeman ML +10 more
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