No evidence of neuronal damage as measured by neurofilament light chain in a HIV cure study utilising a kick-and-kill approach [PDF]
Journal of Virus Eradication, 2021 Objective: HIV-remission strategies including kick-and-kill could induce viral transcription and immune-activation in the central nervous system, potentially causing neuronal injury.
Jonathan Underwood, John Frater
exaly +4 more sources
Landscape review of current HIV ‘kick and kill’ cure research - some kicking, not enough killing [PDF]
BMC Infectious Diseases, 2017 Background Current antiretroviral therapy (ART) used to treat human immunodeficiency virus (HIV) patients is life-long because it only suppresses de novo infections.
Kristian Thorlund +2 more
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Epigenetic landscape in the kick-and-kill therapeutic vaccine BCN02 clinical trial is associated with antiretroviral treatment interruption (ATI) outcome [PDF]
EBioMedicine, 2022 Summary: Background: The BCN02-trial combined therapeutic vaccination with a viral latency reversing agent (romidepsin, RMD) in HIV-1-infected individuals and included a monitored antiretroviral pause (MAP) as an efficacy read-out identifying ...
Martin Tolstrup +2 more
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In vivo Effects of Romidepsin on T-Cell Activation, Apoptosis and Function in the BCN02 HIV-1 Kick&Kill Clinical Trial [PDF]
Frontiers in Immunology, 2020 Romidepsin (RMD) is a well-characterized histone deacetylase inhibitor approved for the treatment of cutaneous T-cell lymphoma. in vitro and in vivo studies have demonstrated that it is able to induce HIV-1 gene expression in latently infected CD4+ T ...
Miriam Rosás-Umbert +65 more
doaj +2 more sources
PKC inhibitors reveal PKC isoforms involved in HIV latency reversal and immunomodulation [PDF]
Journal of VirologyThe reservoir of persistently latently infected cells is a major barrier to a cure for HIV infection. Protein kinase C (PKC) modulators can reverse HIV latency and could thus be useful “Kick” components in “Kick and Kill” approaches to a cure.
Thomas D. Zaikos +10 more
doaj +2 more sources
In vivo activation of latent HIV with a synthetic bryostatin analog effects both latent cell "kick" and "kill" in strategy for virus eradication. [PDF]
PLoS Pathogens, 2017 The ability of HIV to establish a long-lived latent infection within resting CD4+ T cells leads to persistence and episodic resupply of the virus in patients treated with antiretroviral therapy (ART), thereby preventing eradication of the disease ...
Matthew D Marsden +11 more
doaj +2 more sources
Targeting Latent HIV Reservoirs: Effectiveness of Combination Therapy with HDAC and PARP Inhibitors [PDF]
VirusesThe “Kick and Kill” strategy, which aims to reactivate latent HIV reservoirs and facilitate the clearance of reactivated HIV-infected cells, has yet to achieve a functional cure due to the limited efficacy of current latency reversal agents.
Hasset Tibebe +9 more
doaj +2 more sources
Defining the Effects of PKC Modulator HIV Latency-Reversing Agents on Natural Killer Cells [PDF]
Pathogens and ImmunityBackground: Latency reversing agents (LRAs) such as protein kinase C (PKC) modulators can reduce rebound-competent HIV reservoirs in small animal models.
Melanie Dimapasoc +8 more
doaj +2 more sources
Latency Reversing Agents: Kick and Kill of HTLV-1? [PDF]
International Journal of Molecular Sciences, 2021 Andrea K. Kress +2 more
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Energy Science and Engineering, 2022 Workover of natural gas wells in deep carbonate gas reservoirs (DCRs) is facing multiple challenges such as fluid leakage, high temperature, and hydrogen sulfide (H2S) gas kick.
Chinedu J Okere, Guandong Su
exaly +2 more sources