Modeling Kick-Kill Strategies toward HIV Cure [PDF]
Frontiers in Immunology, 2017 Although combinatorial antiretroviral therapy (cART) potently suppresses the virus, a sterile or functional cure still remains one of the greatest therapeutic challenges worldwide.
Esteban A. Hernandez-Vargas
doaj +5 more sources
A Randomized Comparison of Antiretroviral Therapy Alone Versus Antiretroviral Therapy with a 'Kick-and-Kill' Approach, on Measures of the HIV Reservoir Amongst Participants with Recent HIV Infection: The RIVER Trial [PDF]
SSRN Electronic Journal, 2019 Summary Background: Antiretroviral therapy (ART) cannot cure HIV infection because of a persistent reservoir of latently infected cells. Approaches that force HIV transcription from these cells, making them susceptible to killing - termed ‘kick and kill’ - have been explored as a strategy towards an HIV cure.
Fidler, Sarah +26 more
core +14 more sources
Sting agonist as a kick and kill agent to target the HIV reservoir
Journal of Virus Eradication, 2019 D M Margolis, A Chahroudi
exaly +4 more sources
The Use of Seismic Attributes and Well Logs in Delineating Kick Horizon; A Case Study of Nova Well, Niger Delta Basin, Nigeria [PDF]
Journal of Applied Sciences and Environmental Management, 2022 Predrill pore pressure prediction of the NOVA well suggested that the drilling program was in agreement with available seismic surveys. However, a kick was encountered while during the well.
K. O. Ejairu
doaj +2 more sources
Determining the difference of kick tolerance with single bubble and dynamic multiphase models: Evaluation of well-control with water/synthetic based muds [PDF]
Ain Shams Engineering Journal, 2022 Determining the magnitude of an influx into the wellbore when a kick event occurs is very important during well design as well as the well execution phases. This research is conducted to determine the kick tolerance where the single bubble phase model is
Javed Akbar Khan +3 more
doaj +2 more sources
Role of Dendritic Cells in Exposing Latent HIV-1 for the Kill
Viruses, 2019 The development of effective yet nontoxic strategies to target the latent human immunodeficiency virus-1 (HIV-1) reservoir in antiretroviral therapy (ART)-suppressed individuals poses a critical barrier to a functional cure.
Jan Kristoff +2 more
doaj +2 more sources
Inhibition of ALKBH5 demethylase of m6A pathway potentiates HIV-1 reactivation from latency [PDF]
Virology JournalBackground Current latency-reversing agents (LRAs) employed in the “shock-and-kill” strategy primarily focus on relieving epigenetic and transcriptional blocks to reactivate the latent HIV-1.
Haider Ali +18 more
doaj +2 more sources
Can we just kick-and-kill HIV: possible challenges posed by the epigenetically controlled interplay between HIV and host immunity. [PDF]
Immunotherapy, 2019 Ruiz-Riol M, Brander C.
europepmc +4 more sources
Molecular Modeling and Synthesis of New HIV Latency-Reversing Agents Targeting the Lymphatic System
Medical Sciences Forum, 2022 During the HIV infection, a small amount of the virus remains in a latent state, forming a viral reservoir in places with limited access to drugs such as lymph nodes. HIV latency reversing agents, as HDAC inhibitors, have been used in the “kick and kill”
Beatriz Meduqui Rodrigues +3 more
doaj +1 more source