Results 91 to 100 of about 26,399 (169)

Interleukin-15-Stimulated Natural Killer Cells Clear HIV-1-Infected Cells following Latency Reversal Ex Vivo

, 2018
Current efforts toward human immunodeficiency virus (HIV) eradication include approaches to augment immune recognition and elimination of persistently infected cells following latency reversal.
Carolina Garrido, Natalia Soriano-Sarabia, Marina Tuyishime, Maria Abad-Fernandez, David M. Margolis, Justin J. Pollara, Guido Ferrari   +6 more
core   +1 more source

Croton oligandrus Pierre & Hutch (Euphorbiaceae) Extracts and Isolated Compounds Reverse HIV-1 Latency

Journal of Experimental Pharmacology
Chantal Emade Nkwelle,1,2 Smith B Babiaka,3,4 Clovis S Metuge,2,3 Kimberly Liang,5 Unique Stephens,5 Seraphine Nkie Esemu,1 David S Zuzga,5 Kristy Shuda McGuire,5 Luis J Montaner,5 Roland N Ndip,1 Ian Tietjen,5 Fidele Ntie-Kang2,3,6 1Department of ...
Emade Nkwelle C, Babiaka SB, Metuge CS, Liang K, Stephens U, Esemu SN, Zuzga DS, Shuda McGuire K, Montaner LJ, Ndip RN, Tietjen I, Ntie-Kang F   +11 more
doaj  

High concentrations of Maraviroc do not alter immunological and metabolic parameters of CD4 T cells

Scientific Reports
Maraviroc (MVC) is an antiretroviral drug capable of binding to CCR5 receptors and block HIV entry into target cells. Moreover, MVC can activate NF-kB pathway and induce viral transcription in HIV-infected cells, being proposed as a latency reversal ...
Erick De La Torre Tarazona, Caroline Passaes, Santiago Moreno, Asier Sáez-Cirión, José Alcamí   +4 more
doaj   +1 more source

Ansellone J, a Potent in Vitro and ex Vivo HIV‑1 Latency Reversal Agent Isolated from a Phorbas sp. Marine Sponge

Five new minor sesterterpenoids, ansellones H (4), I (5), J (6), and K (7) and phorone C (8), have been isolated from a Phorbas sp. marine sponge collected in British Columbia. Their structures have been elucidated by detailed analysis of NMR and MS data.
Raymond J. Andersen (155984), Silven Read (3915155), Karam Mounzer (5408), Amanda Sciorillo (12511258), Nicole de Voogd (12511273), David E. Williams (155960), Kwasi Gyampoh (12511264), Guorui Zu (12511267), Ian Tietjen (140813), Meng Wang (124646), Donya Naz Divsalar (12511261), Luis J. Montaner (12511270), Zhe Yuan (306523)   +12 more
core   +1 more source

Noncanonical-NF-κB activation and DDX3 inhibition reduces the HIV-1 reservoir by elimination of latently infected cells ex-vivo

Microbiology Spectrum
Latency reversal and subsequent elimination of the human immunodeficiency virus-1 (HIV-1) reservoir using a combination of compounds with different mechanisms of action are considered a promising tool for HIV-1 cure.
Jade Jansen, Stefanie Kroeze, Shirley Man, Matteo Andreini, Jan-Willem Bakker, Claudio Zamperini, Alessia Tarditi, Neeltje A. Kootstra, Teunis B. H. Geijtenbeek   +8 more
doaj   +1 more source

The impact of heptose phosphates on HIV latency and human immune responses

, 2023
Use of HIV-specific antiretroviral therapeutic agents (ARTs) achieves total control of viremia and prevents progression of HIV to AIDS, but they are not a cure.
Guvenc, Furkan
core  

Beyond Antiretroviral Therapy: Molecular and Immunological Innovations in HIV Treatment

Tropical Medicine and Infectious Disease
Despite prolonged viral inhibition with combination antiretroviral therapy (ART), HIV-1 survives as genetically intact, replication-capable proviruses within durable CD4+ T-cell fractions, involving central memory, transitional memory, and stem cell-like
Awadh Alanazi, Mohamed N. Ibrahim, Mohamed A. Elithy   +2 more
doaj   +1 more source

A truncated HIV Tat demonstrates potent and specific latency reversal activity. [PDF]

Antimicrob Agents Chemother, 2023
Van Gulck E, Pardons M, Nijs E, Verheyen N, Dockx K, Van Den Eynde C, Battivelli E, Vega J, Florence E, Autran B, Archin NM, Margolis DM, Katlama C, Hamimi C, Van Den Wyngaert I, Eyassu F, Vandekerckhove L, Boden D.   +17 more
europepmc   +1 more source

How fast can we see? The latency development in human infants to pattern, orientation, and direction-reversal visual evoked potentials

, 2012
The goal of this thesis is to track latency changes in three visual evoked potentials (VEP) stimuli as an indication of overall brain development, in order to provide a normative baseline to differentiate visual and neurological development from ...
Lee, Jin
core   +1 more source

HIV latency reversal using designed PKC modulators

Journal of Virus Eradication, 2017
M.D. Marsden, T.W. Chun, P.A. Wender, J.A. Zack   +3 more
doaj   +1 more source