Off-Target Effect of Activation of NF-κB by HIV Latency Reversal Agents on Transposable Elements Expression [PDF]
Viruses, 2022 Many drugs have been evaluated to reactivate HIV-1 from cellular reservoirs, but the off-target effects of these latency reversal agents (LRA) remain poorly defined.
Gislaine Curty +4 more
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Polyanionic carbosilane dendrimers as a new adjuvant in combination with latency reversal agents for HIV treatment [PDF]
Journal of Nanobiotechnology, 2019 Background The major obstacle impeding human immunodeficiency virus-1 (HIV-1) eradication in antiretroviral treatment (ART) treated HIV-1 subjects is the establishment of long-lived latently infected resting CD4+ T cells. Due to the fact that no drug has
Ignacio Relaño-Rodríguez +4 more
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Latency reversal agents modulate HIV antigen processing and presentation to CD8 T cells. [PDF]
PLoS Pathogens, 2020 Latency reversal agents (LRA) variably induce HIV re-expression in CD4 T cells but reservoirs are not cleared. Whether HIV epitope presentation is similar between latency reversal and initial infection of CD4 T cells is unknown yet crucial to define ...
Julie Boucau +3 more
doaj +2 more sources
Reanalysis of Gene Expression Profiles of CD4+ T Cells Treated with HIV-1 Latency Reversal Agents [PDF]
Microorganisms, 2020 The human immunodeficiency virus (HIV-1) causes a progressive depletion of CD4+ T cells, hampering immune function. Current experimental strategies to fight the virus focus on the reactivation of latent HIV-1 in the viral reservoir to make the virus ...
Antonio Victor Campos Coelho +2 more
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PKC inhibitors reveal PKC isoforms involved in HIV latency reversal and immunomodulation [PDF]
Journal of VirologyThe reservoir of persistently latently infected cells is a major barrier to a cure for HIV infection. Protein kinase C (PKC) modulators can reverse HIV latency and could thus be useful “Kick” components in “Kick and Kill” approaches to a cure.
Thomas D. Zaikos +10 more
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Latency reversal agents affect differently the latent reservoir present in distinct CD4+ T subpopulations. [PDF]
PLoS Pathogens, 2019 Latency reversal agents (LRAs) have proven to induce HIV-1 transcription in vivo but are ineffective at decreasing the size of the latent reservoir in antiretroviral treated patients.
Judith Grau-Expósito +13 more
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HIVGKO: A Tool to Assess HIV-1 Latency Reversal Agents in Human Primary CD4+ T Cells [PDF]
Bio-Protocol, 2018 While able to suppress HIV replication in HIV infected individuals, combination antiretroviral therapy (ART) fails to eliminate viral latent reservoir, which consists in integrated transcriptional silenced HIV provirus. So far, identification of latently-
Emilie Battivelli, Eric Verdin
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Small Molecule Inhibitors of BAF; A Promising Family of Compounds in HIV-1 Latency Reversal
EBioMedicine, 2016 Persistence of latently infected cells in presence of Anti-Retroviral Therapy presents the main obstacle to HIV-1 eradication. Much effort is thus placed on identification of compounds capable of HIV-1 latency reversal in order to render infected cells ...
Mateusz Stoszko +10 more
doaj +3 more sources
Breaking into HIV-1’s Epigenetic Vault: Cure Strategies to Eliminate the Viral Reservoir [PDF]
VirusesHuman immunodeficiency virus type 1 (HIV-1) is a retrovirus that integrates into the host cell’s DNA as a provirus. Transcription from the provirus is regulated in large part by cellular proteins and epigenetic factors.
Joanna E. Jones +3 more
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Emerging Microbes and InfectionsTo date, an affordable, effective treatment for an HIV-1 cure remains only a concept with most “latency reversal” agents (LRAs) lacking specificity for the latent HIV-1 reservoir and failing in early clinical trials.
Minh Ha Ngo +25 more
doaj +3 more sources