Results 11 to 20 of about 9,108 (204)

Novel Latency Reversal Agents for HIV-1 Cure [PDF]

Annual Review of Medicine, 2018
Vicente Planelles, Adam M Spivak
exaly   +2 more sources

Modulation of IRF7-driven transcription as a strategy to control HIV-1 latency [PDF]

Frontiers in Immunology
BackgroundThe persistence of latent HIV-1 reservoirs remains a major barrier to achieving a cure for HIV. While latency-reversing agents (LRAs) have been extensively studied, latency-promoting agents (LPAs) offer a complementary strategy to silence viral
Ifeanyi Jude Ezeonwumelu, Ifeanyi Jude Ezeonwumelu, Edurne Garcia-Vidal, Edurne Garcia-Vidal, Eudald Felip, Eudald Felip, Eudald Felip, Sara Cabrero-de las Heras, Sara Cabrero-de las Heras, Bonaventura Clotet, Bonaventura Clotet, Roger Badia, Roger Badia, Ester Ballana, Ester Ballana, Ester Ballana, Eva Riveira-Muñoz, Eva Riveira-Muñoz, Maria Nevot, Maria Nevot   +19 more
doaj   +2 more sources

The Effect of Latency Reversal Agents on Primary CD8+ T Cells: Implications for Shock and Kill Strategies for Human Immunodeficiency Virus Eradication [PDF]

EBioMedicine, 2016
Christopher W Pohlmeyer, Patrick Tarwater, Joel N Blankson   +2 more
exaly   +2 more sources

Nanoparticle delivery of Tat synergizes with classical latency reversal agents to express HIV antigen targets [PDF]

Antimicrobial Agents and Chemotherapy
Nancie M Archin, Ellen van Gulck
exaly   +2 more sources

New Concepts in Therapeutic Manipulation of HIV-1 Transcription and Latency: Latency Reversal versus Latency Prevention

Viruses, 2023
Antiretroviral therapy (ART) has dramatically improved the prognosis for people living with HIV-1, but a cure remains elusive. The largest barrier to a cure is the presence of a long-lived latent reservoir that persists within a heterogenous mix of cell ...
Catherine A. Lewis, David M. Margolis, Edward P. Browne   +2 more
doaj   +1 more source

A CRISPR Screen of HIV Dependency Factors Reveals That CCNT1 Is Non-Essential in T Cells but Required for HIV-1 Reactivation from Latency

Viruses, 2023
We sought to explore the hypothesis that host factors required for HIV-1 replication also play a role in latency reversal. Using a CRISPR gene library of putative HIV dependency factors, we performed a screen to identify genes required for latency ...
Terry L. Hafer, Abby Felton, Yennifer Delgado, Harini Srinivasan, Michael Emerman   +4 more
doaj   +1 more source

Trade-off between synergy and efficacy in combinations of HIV-1 latency-reversing agents. [PDF]

PLoS Computational Biology, 2018
Eradicating HIV-1 infection is difficult because of the reservoir of latently infected cells that gets established soon after infection, remains hidden from antiretroviral drugs and host immune responses, and retains the capacity to reignite infection ...
Vipul Gupta, Narendra M Dixit
doaj   +1 more source

Activation of the Anti-Oxidative Stress Response Reactivates Latent HIV-1 Through the Mitochondrial Antiviral Signaling Protein Isoform MiniMAVS

Frontiers in Immunology, 2021
The mitochondrial antiviral signaling protein (MAVS) is part of the cell’s innate immune mechanism of defense. MAVS mRNA is bicistronic and can give rise to a full length-MAVS and a shorter isoform termed miniMAVS.
Indra Sarabia, Camille L. Novis, Amanda B. Macedo, Hiroshi Takata, Racheal Nell, Juyeon C. Kakazu, Robert L. Furler, Binita Shakya, Heidi L. Schubert, Christopher P. Hill, Ana Beatriz DePaula-Silva, Adam M. Spivak, Lydie Trautmann, Vicente Planelles, Alberto Bosque   +14 more
doaj   +1 more source

Moving Toward a Functional Cure for HIV-1

Infectious Diseases & Immunity, 2021
. Despite the recent success of suppressing human immunodeficiency virus 1 (HIV-1) replication in the peripheral blood with antiretroviral therapy, elimination of the provirus from infected cells remains challenging because the virus can integrate into ...
Wen Kang, Yongtao Sun, Haijuan Wang
doaj   +1 more source

Human Immunodeficiency Virus-1 Latency Reversal via the Induction of Early Growth Response Protein 1 to Bypass Protein Kinase C Agonist-Associated Immune Activation

Frontiers in Microbiology, 2022
Human Immunodeficiency Virus-1 (HIV) remains a global health challenge due to the latent HIV reservoirs in people living with HIV (PLWH). Dormant yet replication competent HIV harbored in the resting CD4+ T cells cannot be purged by antiretroviral ...
Lilly M. Wong, Dajiang Li, Yuyang Tang, Gema Méndez-Lagares, George R. Thompson, Dennis J. Hartigan-O’Connor, Satya Dandekar, Guochun Jiang, Guochun Jiang   +8 more
doaj   +1 more source