Results 21 to 30 of about 388,981 (242)
Sensing of HIV-1 by TLR8 activates human T cells and reverses latency
Nature Communications, 2020 Manipulation of Toll-like receptors (TLRs) affects HIV-1 infection and latency reversal. Here, the authors show that HIV-1 is endocytosed and recognized by TLR8 in human primary CD4+T cells and that TLR8 stimulation induces an inflammatory response that ...
Hany Zekaria Meås +11 more
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Issues in Implementing Latency Insensitive Protocols [PDF]
, 2004 The latency insensitive protocols (LIP), which are designed to improve the performance of systems-on-chip, were refined. The refined protocol was validated by using many proof-of-concept examples, that comprised of various combinations of feedforward and
L. Macchiarulo +3 more
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Adaptive Latency Insensitive Protocols [PDF]
, 2007 Latency-insensitive design copes with excessive delays typical of global wires in current and future IC technologies. It achieves its goal via encapsulation of synchronous logic blocks in wrappers that communicate through a latency-insensitive protocol ...
Casu, Mario Roberto, Macchiarulo, Luca
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The Journal of Clinical Investigation, 2022 Latency reversal strategies for HIV cure using inhibitor of apoptosis protein (IAP) antagonists (IAPi) induce unprecedented levels of latent reservoir expression without immunotoxicity during suppressive antiretroviral therapy (ART).
Shane D. Falcinelli +30 more
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De Novo synthesis of VP16 coordinates the exit from HSV latency in vivo [PDF]
, 2009 The mechanism controlling the exit from herpes simplex virus latency (HSV) is of central importance to recurrent disease and transmission of infection, yet interactions between host and viral functions that govern this process remain unclear. The cascade
Sawtell, N.M. +5 more
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Latency reversal agents modulate HIV antigen processing and presentation to CD8 T cells.
PLoS Pathogens, 2020 Latency reversal agents (LRA) variably induce HIV re-expression in CD4 T cells but reservoirs are not cleared. Whether HIV epitope presentation is similar between latency reversal and initial infection of CD4 T cells is unknown yet crucial to define ...
Julie Boucau +3 more
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Humanized Mice for the Evaluation of Novel HIV-1 Therapies
Frontiers in Immunology, 2021 With the discovery of antiretroviral therapy, HIV-1 infection has transitioned into a manageable but chronic illness, which requires lifelong treatment. Nevertheless, complete eradication of the virus has still eluded us.
Shawn Abeynaike +3 more
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NSC95397 Is a Novel HIV-1 Latency-Reversing Agent
VirusesThe latent viral reservoir represents one of the major barriers to curing HIV-1. Focus on the “kick and kill” (also called “shock and kill”) approach, in which virus expression is reactivated, and then cells producing virus are selectively depleted, has ...
Randilea Nichols Doyle +5 more
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An investigation of herpes simplex virus promoter activity compatible with latency establishment reveals VP16-independent activation of immediate-early promoters in sensory neurones [PDF]
, 2011 Herpes simplex virus (HSV) type-1 establishes lifelong latency in sensory neurones and it is widely assumed that latency is the consequence of a failure to initiate virus immediate-early (IE) gene expression. However, using a Ore reporter mouse system in
Heather M. Coleman +13 more
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CBP/p300 lysine acetyltransferases inhibit HIV-1 expression in latently infected T cells
iScienceSummary: HIV-1 latency is regulated by chromatin modifying enzymes, and histone deacetylase inhibitors (HDACi) cause reactivation of provirus expression.
Riley M. Horvath, Ivan Sadowski
doaj +1 more source