Results 21 to 30 of about 26,399 (169)

Latency Reversing Agents and the Road to an HIV Cure

Pathogens
HIV-1 infection cannot be cured due to the presence of HIV-1 latently infected cells. These cells do not produce the virus, but they can resume virus production at any time in the absence of antiretroviral therapy. Therefore, people living with HIV (PLWH)
Louis Tioka, Rafael Ceña Diez, Anders Sönnerborg, Maarten A. A. van de Klundert   +3 more
doaj   +4 more sources

Mathematical modeling and mechanisms of HIV latency for personalized anti latency therapies

npj Systems Biology and Applications
Combination antiretroviral therapy controls human immunodeficiency virus-1 (HIV) but cannot eradicate latent proviruses in immune cells, which reactivate upon treatment interruption.
Gianmarco Rasi, Elena Emili, Jessica M. Conway, Nicola Cotugno, Paolo Palma   +4 more
doaj   +2 more sources

Combinatorial latency reversal activity of inhibitor of apoptosis antagonists with mechanistically distinct classes of HIV latency reversal agents

Journal of Virus Eradication, 2019
Shane D. Falcinelli, David M. Irlbeck, Anne-Marie Turner, Frances Potjewyd, Lindsey I. James, David M. Margolis, Nancie M. Archin, Richard M. Dunham   +7 more
doaj   +2 more sources

Potent latency reversal by Tat RNA-containing nanoparticle enables multi-omic analysis of the HIV-1 reservoir. [PDF]

Nat Commun, 2023
Source data from the article "Potent latency reversal by Tat RNA-containing nanoparticle enables multi-omic analysis of the HIV-1 reservoir"
Pardons M, Cole B, Lambrechts L, van Snippenberg W, Rutsaert S, Noppe Y, De Langhe N, Dhondt A, Vega J, Eyassu F, Nijs E, Van Gulck E, Boden D, Vandekerckhove L.   +13 more
europepmc   +2 more sources

Natural killer cells induce HIV-1 latency reversal after treatment with pan-caspase inhibitors. [PDF]

Front Immunol, 2022
The establishment of a latency reservoir is the major obstacle for a cure of HIV-1. The shock-and-kill strategy aims to reactivate HIV-1 replication in HIV -1 latently infected cells, exposing the HIV-1-infected cells to cytotoxic lymphocytes.
Furtado Milão J, Love L, Gourgi G, Derhaschnig L, Svensson JP, Sönnerborg A, van Domselaar R.   +6 more
europepmc   +2 more sources

A CRISPR Screen of HIV Dependency Factors Reveals That CCNT1 Is Non-Essential in T Cells but Required for HIV-1 Reactivation from Latency

Viruses, 2023
We sought to explore the hypothesis that host factors required for HIV-1 replication also play a role in latency reversal. Using a CRISPR gene library of putative HIV dependency factors, we performed a screen to identify genes required for latency ...
Terry L. Hafer, Abby Felton, Yennifer Delgado, Harini Srinivasan, Michael Emerman   +4 more
doaj   +1 more source

23 Understanding the effects of latency reversing agents on HIV RNA splicing: implications for latency reversal

Journal of Virus Eradication, 2016
T.M. Mota, G. Khoury, J.C. Jacobson, H.K. Lu, F. Wightman, d.e.r. Sluis, J.L. Anderson, P.U. Cameron, S.R. Lewin, D.F.J. Purcell, R.M. Van   +10 more
doaj   +2 more sources

Mechanism by Which PF-3758309, a Pan Isoform Inhibitor of p21-Activated Kinases, Blocks Reactivation of HIV-1 Latency

Biomolecules, 2023
The “block and lock” strategy is one approach that might elicit a sterilizing cure for HIV-1 infection. The “block” refers to a compound’s ability to inhibit latent HIV-1 proviral transcription, while the “lock” refers to its capacity to induce permanent
Benni Vargas, James Boslett, Nathan Yates, Nicolas Sluis-Cremer   +3 more
doaj   +1 more source

The Pathway To Establishing HIV Latency Is Critical to How Latency Is Maintained and Reversed [PDF]

Journal of Virology, 2018
ABSTRACT HIV infection requires lifelong antiretroviral therapy because of the persistence of latently infected CD4 + T cells. The induction of virus expression from latently infected cells occurs following T cell receptor (TCR) activation, but not all latently infected cells respond to TCR stimulation. We
Simin D. Rezaei, Hao K. Lu, J. Judy Chang, Ajantha Rhodes, Sharon R. Lewin, Paul U. Cameron   +5 more
openaire   +2 more sources

Shocking HIV-1 with immunomodulatory latency reversing agents [PDF]

Seminars in Immunology, 2021
The "shock-and-kill" strategy is one of the most explored HIV-1 cure approaches to eliminate latent virus. This strategy is based on HIV-1 reactivation using latency reversing agents (LRAs) to reactivate latent proviruses (the "shock" phase) and to induce subsequent elimination of the reactivated cells by immune responses or virus-induced cytopathic ...
Anna Kula-Pacurar, Anthony Rodari, Gilles Darcis, Carine Van Lint   +3 more
openaire   +4 more sources