Results 21 to 30 of about 25,365 (244)
Biomolecules, 2023 The “block and lock” strategy is one approach that might elicit a sterilizing cure for HIV-1 infection. The “block” refers to a compound’s ability to inhibit latent HIV-1 proviral transcription, while the “lock” refers to its capacity to induce permanent
Benni Vargas +3 more
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The Pathway To Establishing HIV Latency Is Critical to How Latency Is Maintained and Reversed [PDF]
Journal of Virology, 2018 ABSTRACT HIV infection requires lifelong antiretroviral therapy because of the persistence of latently infected CD4 + T cells. The induction of virus expression from latently infected cells occurs following T cell receptor (TCR) activation, but not all latently infected cells respond to TCR stimulation. We
Simin D. Rezaei +5 more
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Trade-off between synergy and efficacy in combinations of HIV-1 latency-reversing agents. [PDF]
PLoS Computational Biology, 2018 Eradicating HIV-1 infection is difficult because of the reservoir of latently infected cells that gets established soon after infection, remains hidden from antiretroviral drugs and host immune responses, and retains the capacity to reignite infection ...
Vipul Gupta, Narendra M Dixit
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Position effects influence HIV latency reversal [PDF]
Nature Structural & Molecular Biology, 2016 The main obstacle to curing HIV is the presence of latent proviruses in the bodies of infected patients. The partial success of reactivation therapies suggests that the genomic context of integrated proviruses can interfere with treatment. Here we developed a method called Barcoded HIV ensembles (B-HIVE) to map the chromosomal locations of thousands of
Heng-Chang Chen +4 more
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Shocking HIV-1 with immunomodulatory latency reversing agents [PDF]
Seminars in Immunology, 2021 The "shock-and-kill" strategy is one of the most explored HIV-1 cure approaches to eliminate latent virus. This strategy is based on HIV-1 reactivation using latency reversing agents (LRAs) to reactivate latent proviruses (the "shock" phase) and to induce subsequent elimination of the reactivated cells by immune responses or virus-induced cytopathic ...
Anna Kula-Pacurar +3 more
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Combination Immune Checkpoint Blockade to Reverse HIV Latency [PDF]
The Journal of Immunology, 2020 Abstract In people living with HIV on antiretroviral therapy, HIV latency is the major barrier to a cure. HIV persists preferentially in CD4+ T cells expressing multiple immune checkpoint (IC) molecules, including programmed death (PD)-1, T cell Ig and mucin domain-containing protein 3 (TIM-3), lymphocyte associated gene 3 (LAG-3), and T
Renée M Van der Sluis +11 more
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A Two-Color Haploid Genetic Screen Identifies Novel Host Factors Involved in HIV-1 Latency
mBio, 2021 To identify novel host factors as putative targets to reverse HIV-1 latency, we performed an insertional mutagenesis genetic screen in a latent HIV-1 infected pseudohaploid KBM7 cell line (Hap-Lat).
Michael Röling +13 more
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Nanoparticle delivery of Tat synergizes with classical latency reversal agents to express HIV antigen targets [PDF]
Antimicrobial Agents and Chemotherapy, Nancie Archin, Ellen Van Gulck
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Reversed short-latency ocular following
Vision Research, 2002 Using the scleral search coil technique to monitor eye movements, we recorded short-latency ocular following responses to displacement steps of large random-dot patterns. On half of the trials, the luminance of the dots and background were reversed during the step, a procedure that is known to reverse the direction of the perceived motion ("reverse phi"
Masson, Guillaume, Yang, D-S, Miles, F.A
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