Results 21 to 30 of about 32,738 (234)
New Latency Reversing Agents for HIV-1 Cure: Insights from Nonhuman Primate Models
Viruses, 2021 Antiretroviral therapy (ART) controls human immunodeficiency virus 1 (HIV-1) replication and prevents disease progression but does not eradicate HIV-1.
Katherine M. Bricker +2 more
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The role of miR-29a in HIV-1 replication and latency
Journal of Virus Eradication, 2017 The development of an effective HIV-1 eradication strategy relies upon a clear understanding of the cellular mechanisms involved in HIV-1 latency. Among such cellular processes, microRNA activities affect HIV-1 production by regulating viral transcripts ...
Giacomo Frattari +2 more
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Reanalysis of Gene Expression Profiles of CD4+ T Cells Treated with HIV-1 Latency Reversal Agents
Microorganisms, 2020 The human immunodeficiency virus (HIV-1) causes a progressive depletion of CD4+ T cells, hampering immune function. Current experimental strategies to fight the virus focus on the reactivation of latent HIV-1 in the viral reservoir to make the virus ...
Antonio Victor Campos Coelho +2 more
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HIV Latency and Nanomedicine Strategies for Anti-HIV Treatment and Eradication
Biomedicines, 2023 Antiretrovirals (ARVs) reduce Human Immunodeficiency Virus (HIV) loads to undetectable levels in infected patients. However, HIV can persist throughout the body in cellular reservoirs partly due to the inability of some ARVs to cross anatomical barriers ...
Mickensone Andre +2 more
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Aminobisphosphonates reactivate the latent reservoir in people living with HIV-1
Frontiers in Immunology, 2023 Antiretroviral therapy (ART) is not curative due to the existence of cellular reservoirs of latent HIV-1 that persist during therapy. Current research efforts to cure HIV-1 infection include “shock and kill” strategies to disrupt latency using small ...
Marta Sanz +29 more
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Viruses, 2020 Human immunodeficiency virus (HIV-1) indefinitely persists, despite effective antiretroviral therapy (ART), within a small pool of latently infected cells. These cells often display markers of immunologic memory and harbor both replication-competent and -
Roland Schwarzer +2 more
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The Third and Fatal Shock: How Pandemic Killed the Millennial Paradigm [PDF]
SSRN Electronic Journal, 2020 AbstractThis millennium began with widespread acceptance of a governing paradigm emphasizing small government, free markets, and open borders. Three crises—the 9/11 attacks, the 2008 financial crisis, and the 2020 COVID‐19 pandemic—forced American policy makers to diverge from this paradigm.
openaire +2 more sources
Horses killed and injured by electric shock [PDF]
Journal of Comparative Pathology and Therapeutics, 1901 n ...
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Are BET Inhibitors yet Promising Latency-Reversing Agents for HIV-1 Reactivation in AIDS Therapy?
Viruses, 2021 AIDS first emerged decades ago; however, its cure, i.e., eliminating all virus sources, is still unachievable. A critical burden of AIDS therapy is the evasive nature of HIV-1 in face of host immune responses, the so-called “latency.” Recently, a ...
Thanarat Salahong +2 more
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Block-And-Lock Strategies to Cure HIV Infection
Viruses, 2020 Today HIV infection cannot be cured due to the presence of a reservoir of latently infected cells inducing a viral rebound upon treatment interruption. Hence, the latent reservoir is considered as the major barrier for an HIV cure.
Gerlinde Vansant +3 more
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