Results 81 to 90 of about 854,837 (280)

ALDOA Promotes Glycolysis and NLRP3/GSDMD Pyroptosis to Accelerate ALS Progression

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Amyotrophic lateral sclerosis (ALS) is characterized by progressive motor neuron degeneration. Glycolytic dysregulation is implicated in disease progression, yet the underlying mechanisms remain unclear. This study investigates how Aldolase A (ALDOA) drives ALS progression through glycolysis‐mediated motor neuron pyroptosis.
Kaixin Yan, Yan Jiang, Yuxuan Yong, Tianshuo Zhang, Niannian Zhang, Qianqian Zeng, Xue Gong, Li Meng, Fangfang Bi, Yongmin Liu   +9 more
wiley   +1 more source

Added Prognostic Value of EEG Reactivity in Comatose Patients Following Cardiac Arrest

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives To evaluate the added prognostic value of EEG reactivity for favorable outcome compared with background analysis during and after targeted temperature management (TTM). Methods Prospective observational cohort study of comatose post–cardiac arrest patients admitted to a single academic center between 2017 and 2022, all undergoing ...
Sarah Caroyer, Marie Obrecht, Charlotte de Maeseneire, Charlotte Damien, Chantal Depondt, Lorenzo Ferlini, Estelle Rikir, Filippo Annoni, Fabio Silvio Taccone, Nicolas Mavroudakis, Benjamin Legros, Nicolas Gaspard   +11 more
wiley   +1 more source

Targeting Ikaros and Aiolos with pomalidomide fails to reactivate or induce apoptosis of the latent HIV reservoir

Journal of Virology
HIV persists in people living with HIV (PLHIV) on antiretroviral therapy (ART) in long-lived and proliferating latently infected CD4+ T cells that selectively express pro-survival proteins, including the zinc finger proteins, Ikaros and Aiolos.
Rachel D. Pascoe, Youry Kim, Ajantha Rhodes, Jesslyn Ong, Carolin Tumpach, Celine Gubser, J. Judy Chang, James H. McMahon, Sharon R. Lewin, Thomas A. Rasmussen   +9 more
doaj   +1 more source

Lessons Learned from In Vivo Studies of a Viral Noncoding RNA

mSphere, 2016
Despite increasing interest in the biology of noncoding RNAs (ncRNAs), few functions have been uncovered for viral ncRNAs in vivo. In their recent article in mSphere, Feldman and colleagues [E. R. Feldman et al., mSphere 1(2):e00105-15, 2016, doi:10.1128/
Rodney P. Kincaid, Christopher S. Sullivan   +1 more
doaj   +1 more source

Measuring the Success of HIV-1 Cure Strategies

Frontiers in Cellular and Infection Microbiology, 2020
HIV-1 eradication strategies aim to achieve viral remission in the absence of antiretroviral therapy (ART). The development of an HIV-1 cure remains challenging due to the latent reservoir (LR): long-lived CD4 T cells that harbor transcriptionally silent
Jordan Thomas, Alessandra Ruggiero, Alessandra Ruggiero, William A. Paxton, Georgios Pollakis   +4 more
doaj   +1 more source

White Matter Hyperintensity Burden and Short‐Interval Change Associated With Sleep Apnoea in the UK Biobank

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background and Purpose White matter hyperintensities (WMH) are a core neuroimaging marker of cerebral small vessel disease (CSVD). Sleep apnoea (SA) is a recognized vascular risk factor, but its associations with regional WMH burden, short‐interval WMH change and cognitive performance in population‐based cohorts remain incompletely defined. We
Peng Cheng, Diego Z. Carvalho, Shahid Karim, Anwar Chahal, Virend K. Somers   +4 more
wiley   +1 more source

Okul Öncesi Dönemdeki Çocukların Bilişsel Stillerinin Bazı Değişkenler Açısından İncelenmesi

Selçuk Üniversitesi Sosyal Bilimler Enstitüsü Dergisi, 2009
Bu araştırmanın amacı, okul öncesi dönemdeki çocukların 1 yaşlarına, 2 cinsiyetlerine, 3 kardeşsayılarına, 4 annelerinin 5 babalarının eğitim seviyelerine, 6 devam ettikleri okul türüne göre Kansas Okul Öncesi Çocuklar İçin Düşünsellik ...
Zarife Seçer, Hakan Sarı, Nadir Çeliköz, Ömer Üre   +3 more
doaj  

Self-Adjustable Active Sequence to Reduce Latency in Duty Cycle WSNs

IEEE Access, 2019
The wireless sensor networks (WSNs) have a great application prospect, which is composed of much simple hardware and small-size sensor nodes to realize the perception of the surrounding environment. It is often widely used that nodes work in a duty cycle
Xuan Long, Wei Liu, Tian Wang, Zhiwen Zeng, Ming Ma   +4 more
doaj   +1 more source

Movement Disorders in Aicardi–Goutières Syndrome and Response to Immunomodulation

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT This study characterizes movement disorders and treatment responses in seven children with Aicardi–Goutières syndrome (AGS). We retrospectively evaluated motor phenotypes, neuroimaging, and interferon signatures in patients treated with baricitinib or anifrolumab. Spasticity affected all patients, while dystonia was present in 4/7.
Enrique Gonzalez Saez‐Diez, Monica Ferrer Socorro, Kathryn Yang, Nicole Battaglia, Zainab Zaman, Mariko Bennett, Adeline Vanderver, Pui Y. Lee, Lauren A. Henderson, Milena M. Andzelm, Darius Ebrahimi‐Fakhari   +10 more
wiley   +1 more source

Empirical Evaluation of Wireless Technologies for Resilient and Reliable Remote Control: 5G, Starlink, and Multi-Connectivity

IEEE Access
Wireless technologies are increasingly adopted for industrial video monitoring and remote control due to their flexibility, scalability, and broad coverage.
Weifan Zhang, Rasmus Suhr Mogensen, Carmen Covadonga Blanco Gonzalez, Sebastian Bro Damsgaard, Sokol Kosta, Preben E. Mogensen   +5 more
doaj   +1 more source