Results 31 to 40 of about 291,220 (232)
Viruses, 2023 We sought to explore the hypothesis that host factors required for HIV-1 replication also play a role in latency reversal. Using a CRISPR gene library of putative HIV dependency factors, we performed a screen to identify genes required for latency ...
Terry L. Hafer +4 more
doaj +1 more source
The gammaherpesvirus 68 viral cyclin facilitates expression of LANA.
PLoS Pathogens, 2021 Gammaherpesviruses establish life-long infections within their host and have been shown to be the causative agents of devastating malignancies. Chronic infection within the host is mediated through cycles of transcriptionally quiescent stages of latency ...
Brian F Niemeyer +7 more
doaj +1 more source
A gammaherpesviral internal repeat contributes to latency amplification. [PDF]
, 2007 Gammaherpesviruses cause important infections of humans, in particular in immunocompromised patients. The genomes of gammaherpesviruses contain variable numbers of internal repeats whose precise role for in vivo pathogenesis is not well understood.
Steer, Beatrix +11 more
core +2 more sources
mBio, 2018 We used the Kasumi-3 model to study human cytomegalovirus (HCMV) latency and reactivation in myeloid progenitor cells. Kasumi-3 cells were infected with HCMV strain TB40/Ewt-GFP, flow sorted for green fluorescent protein-positive (GFP+) cells, and ...
Eleonora Forte +5 more
doaj +1 more source
Whole genome sequencing of Mycobacterium tuberculosis reveals slow growth and low mutation rates during latent infections in humans [PDF]
, 2014 Very little is known about the growth and mutation rates of Mycobacterium tuberculosis during latent infection in humans. However, studies in rhesus macaques have suggested that latent infections have mutation rates that are higher than that observed ...
Vic L Arcus +29 more
core +2 more sources
A gammaherpesvirus cooperates with interferon-alpha/beta-induced IRF2 to halt viral replication, control reactivation, and minimize host lethality. [PDF]
PLoS Pathogens, 2011 The gammaherpesviruses, including Epstein-Barr virus (EBV) and Kaposi's sarcoma-associated herpesvirus (KSHV), establish latency in memory B lymphocytes and promote lymphoproliferative disease in immunocompromised individuals.
Pratyusha Mandal +6 more
doaj +1 more source
Heliyon, 2019 HIV-1 persists during antiretroviral therapy (ART) due to long-lived and proliferating latently-infected host cells, with the outcome being an incomplete cure. The latently-infected cells, or reservoir cells, are transcriptionally absent and invisible to
Jutatip Panaampon +3 more
doaj +1 more source
Cell Reports, 2018 Summary: Despite effective treatment, HIV can persist in latent reservoirs, which represent a major obstacle toward HIV eradication. Targeting and reactivating latent cells is challenging due to the heterogeneous nature of HIV-infected cells.
Monica Golumbeanu +6 more
doaj +1 more source
Temperature-induced reactivation of Marek's disease virus-transformed T cells ex vivo
Frontiers in Veterinary Science, 2023 Marek's disease virus (MDV) establishes latency in chicken T lymphocytes that can lead to T cell transformation and cancer. Transformed Marek's disease chicken cell lines (MDCCs) can be expanded ex vivo and provide a valuable model to study latency ...
Yung-Tien Tien +2 more
doaj +1 more source
The role of cellular signalling pathways and translation initiation factors in Herpesvirus infection [PDF]
, 2011 As obligate intracellular parasites, viruses rely on host cells to replicate. Hsv-1 is a large double stranded DNA virus which is the cause of common cold sores and corneal blindness in humans. The defining feature of HSV-1 is its ability to exist in two
McMahon, Robert
core +2 more sources