Results 11 to 20 of about 291,220 (232)
Epigenetic Control of Cytomegalovirus Latency and Reactivation
Viruses, 2013 Cytomegalovirus (CMV) gene expression is repressed in latency due to heterochromatinization of viral genomes. In murine CMV (MCMV) latently infected mice, viral genomes are bound to histones with heterochromatic modifications, to enzymes that mediate ...
Mary Hummel +2 more
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The Role of the Human Cytomegalovirus UL133-UL138 Gene Locus in Latency and Reactivation
Viruses, 2020 Human cytomegalovirus (HCMV) latency, the means by which the virus persists indefinitely in an infected individual, is a major frontier of current research efforts in the field.
Luwanika Mlera +4 more
doaj +2 more sources
PLoS Pathogens, 2023 Previously we reported that the HSV-1 latency associated transcript (LAT) specifically upregulates the cellular herpesvirus entry mediator (HVEM) but no other known HSV-1 receptors.
Ujjaldeep Jaggi +3 more
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RNA-induced epigenetic silencing inhibits HIV-1 reactivation from latency [PDF]
Retrovirology, 2018 Background Current antiretroviral therapy is effective in controlling HIV-1 infection. However, cessation of therapy is associated with rapid return of viremia from the viral reservoir.
Catalina Méndez +4 more
doaj +2 more sources
Mitochondrial protein, TBRG4, modulates KSHV and EBV reactivation from latency [PDF]
PLoS Pathogens, 2022 Kaposi’s sarcoma-associated herpesvirus (KSHV) and Epstein-Barr (EBV) are gammaherpesviruses associated with multiple human malignancies. KSHV is the etiological agent of Kaposi’s Sarcoma, primary effusion lymphoma (PEL) and multicentric Castleman’s ...
Huirong Zhang +5 more
doaj +3 more sources
Towards an Understanding of the Herpes Simplex Virus Type 1 Latency-Reactivation Cycle [PDF]
Interdisciplinary Perspectives on Infectious Diseases, 2010 Infection by herpes simplex virus type 1 (HSV-1) can cause clinical symptoms in the peripheral and central nervous system. Recurrent ocular shedding can lead to corneal scarring and vision loss making HSV-1 a leading cause of corneal blindness due to an ...
Guey-Chuen Perng, Clinton Jones
doaj +2 more sources
Viruses, 2023 Alphaherpesviruses infect humans and most animals. They can cause severe morbidity and mortality. The pseudorabies virus (PRV) is a neurotropic alphaherpesvirus that can infect most mammals. The PRV persists in the host by establishing a latent infection,
Li Pan +7 more
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Mechanisms of Kaposi's Sarcoma-Associated Herpesvirus Latency and Reactivation [PDF]
Advances in Virology, 2011 The life cycle of Kaposi's sarcoma-associated herpesvirus (KSHV) consists of latent and lytic replication phases. During latent infection, only a limited number of KSHV genes are expressed.
Fengchun Ye, Xiufen Lei, Shou-Jiang Gao
doaj +2 more sources
An iPSC-Derived Myeloid Lineage Model of Herpes Virus Latency and Reactivation [PDF]
Frontiers in Microbiology, 2019 Herpesviruses undergo life-long latent infection which can be life-threatening in the immunocompromised. Models of latency and reactivation of human cytomegalovirus (HCMV) include primary myeloid cells, cells known to be important for HCMV latent ...
Emma Poole +20 more
doaj +3 more sources
Stress Can Induce Bovine Alpha-Herpesvirus 1 (BoHV-1) Reactivation from Latency
VirusesBovine alpha-herpesvirus 1 (BoHV-1) is a significant problem for the cattle industry, in part because the virus establishes latency, and stressful stimuli increase the incidence of reactivation from latency.
Fouad El-Mayet, Clinton Jones
doaj +2 more sources