Results 21 to 30 of about 291,220 (232)

KSHV reactivation from latency requires Pim-1 and Pim-3 kinases to inactivate the latency-associated nuclear antigen LANA.

PLoS Pathogens, 2009
Host signal-transduction pathways are intimately involved in the switch between latency and productive infection of herpes viruses. As with other herpes viruses, infection by Kaposi's sarcoma herpesvirus (KSHV) displays these two phases.
Fang Cheng, Magdalena Weidner-Glunde, Markku Varjosalo, Eeva-Marja Rainio, Anne Lehtonen, Thomas F Schulz, Päivi J Koskinen, Jussi Taipale, Päivi M Ojala   +8 more
doaj   +2 more sources

Epitranscriptomic m6A modifications during reactivation of HIV-1 latency in CD4+ T cells

mBio
Despite effective antiretroviral therapy reducing HIV-1 viral loads to undetectable levels, the presence of latently infected CD4+ T cells poses a major barrier to HIV-1 cure.
Tarun Mishra, Stacia Phillips, Yutao Zhao, Bethany Wilms, Chuan He, Li Wu   +5 more
doaj   +2 more sources

Inhibition of ALKBH5 demethylase of m6A pathway potentiates HIV-1 reactivation from latency [PDF]

Virology Journal
Background Current latency-reversing agents (LRAs) employed in the “shock-and-kill” strategy primarily focus on relieving epigenetic and transcriptional blocks to reactivate the latent HIV-1.
Haider Ali, Jakub Wadas, Maryam Bendoumou, Heng-Chang Chen, Paolo Maiuri, Antoine Dutilleul, Simona Selberg, Lorena Nestola, Kamil Lalik, Veronique Avettand-Fenoël, Coca Necsoi, Alessandro Marcello, Esko Kankuri, Mati Karelson, Stéphane De Wit, Krzysztof Pyrc, Alexander O. Pasternak, Carine Van Lint, Anna Kula-Pacurar   +18 more
doaj   +2 more sources

Regulation of KSHV Latency and Lytic Reactivation

Viruses, 2020
Kaposi’s sarcoma-associated herpesvirus (KSHV) is associated with three malignancies— Kaposi’s sarcoma (KS), primary effusion lymphoma (PEL), and multicentric Castleman’s disease (MCD). Central to the pathogenesis of these diseases is the KSHV viral life
Grant Broussard, Blossom Damania
doaj   +2 more sources

Expression of Murine CD80 by Herpes Simplex Virus 1 in Place of Latency-Associated Transcript (LAT) Can Compensate for Latency Reactivation and Anti-apoptotic Functions of LAT. [PDF]

Journal of Virology, 2020
Shaohui Wang, Jack Yu, Ujjaldeep Jaggi
exaly   +2 more sources

Varicella-Zoster viruses associated with post-herpetic neuralgia induce sodium current density increases in the ND7-23 Nav-1.8 neuroblastoma cell line [PDF]

, 2013
Post-herpetic neuralgia (PHN) is the most significant complication of herpes zoster caused by reactivation of latent Varicella-Zoster virus (VZV). We undertook a heterologous infection in vitro study to determine whether PHN-associated VZV isolates ...
Rowan, EG, Kennedy, PGE, Breuer, J, Scott Fiona, Peter G E Kennedy, Esther Grinfeld, Breuer, J., Rowan, E.G., Kennedy Peter G. E., Breuer, Judith, Paul Montague, Fiona Scott, Ashrafi, GH, Ashrafi, G.H., Judith Breuer, Rowan Edward G., Scott, F., Ashrafi G. H., Edward G Rowan, Kennedy, P. G. E., Grinfeld, E, Grinfeld Esther, Rowan, Edward, Montague, P, Montague Paul, Grinfeld, E., Breuer Judith, G H Ashrafi, Kennedy, P.G.E., Montague, P., Scott, F   +30 more
core   +5 more sources

Synergistic Chromatin-Modifying Treatments Reactivate Latent HIV and Decrease Migration of Multiple Host-Cell Types

Viruses, 2021
Upon infection of its host cell, human immunodeficiency virus (HIV) establishes a quiescent and non-productive state capable of spontaneous reactivation.
Alexandra Blanco, Tarun Mahajan, Robert A. Coronado, Kelly Ma, Dominic R. Demma, Roy D. Dar   +5 more
doaj   +1 more source

Human Cytomegalovirus US28 Ligand Binding Activity Is Required for Latency in CD34⁺ Hematopoietic Progenitor Cells and Humanized NSG Mice

mBio, 2019
Human cytomegalovirus (HCMV) infection of CD34+ hematopoietic progenitor cells (CD34+ HPCs) provides a critical reservoir of virus in stem cell transplant patients, and viral reactivation remains a significant cause of morbidity and mortality.
Lindsey B. Crawford, Patrizia Caposio, Craig Kreklywich, Andrew H. Pham, Meaghan H. Hancock, Taylor A. Jones, Patricia P. Smith, Andrew D. Yurochko, Jay A. Nelson, Daniel N. Streblow   +9 more
doaj   +1 more source

De Novo synthesis of VP16 coordinates the exit from HSV latency in vivo [PDF]

, 2009
The mechanism controlling the exit from herpes simplex virus latency (HSV) is of central importance to recurrent disease and transmission of infection, yet interactions between host and viral functions that govern this process remain unclear. The cascade
Sawtell, N.M., Thompson, R.L., Richard L Thompson, Chris M Preston, Nancy M Sawtell, Preston, C.M.   +5 more
core   +1 more source

An investigation of herpes simplex virus promoter activity compatible with latency establishment reveals VP16-independent activation of immediate-early promoters in sensory neurones [PDF]

, 2011
Herpes simplex virus (HSV) type-1 establishes lifelong latency in sensory neurones and it is widely assumed that latency is the consequence of a failure to initiate virus immediate-early (IE) gene expression. However, using a Ore reporter mouse system in
Heather M. Coleman, Connor, V., Proenca, J.T., Michael P. Nicoll, Nicoll, M.P., Jane Arthur, Arthur, J., Preston, C.M., João T. Proença, Christopher M. Preston, Coleman, H.M., Efstathiou, S., Stacey Efstathiou, Viv Connor   +13 more
core   +1 more source