The Bovine Herpesvirus 1 Latency-Reactivation Cycle, a Chronic Problem in the Cattle Industry [PDF]
Viruses, 2023 Bovine alphaherpesvirus 1 (BoHV-1) is a persistent and recurring disease that affects cattle worldwide. It is a major contributor to bovine respiratory disease and reproductive failure in the US.
Jeffery B Ostler, Clinton Jones
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Absence of signal peptide peptidase in peripheral sensory neurons affects latency-reactivation in HSV-1 ocularly infected mice. [PDF]
PLoS Pathogens, 2022 We previously reported that HSV-1 infectivity in vitro and in vivo requires HSV glycoprotein K (gK) binding to the ER signal peptide peptidase (SPP). Anterograde-retrograde transport via peripheral nerves between the site of infection (i.e., eye) and the
Shaohui Wang +4 more
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Herpes simplex virus 1 regulates β-catenin expression in TG neurons during the latency-reactivation cycle. [PDF]
PLoS ONE, 2020 When herpes simplex virus 1 (HSV-1) infection is initiated in the ocular, nasal, or oral cavity, sensory neurons within trigeminal ganglia (TG) become infected.
Kelly S Harrison +3 more
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IFNβ absence compensates for LAT functions in latency reactivation and T cell exhaustion [PDF]
Journal of VirologyType I interferons (IFNs) generate strong antiviral immunity following viral infection in mice and humans. These type I IFNs are encoded by at least 14 IFNα genes and a single IFNβ gene.
Shaohui Wang +3 more
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BK polyomavirus: latency, reactivation, diseases and tumorigenesis [PDF]
Frontiers in Cellular and Infection Microbiology, 2023 The identification of the first human polyomavirus BK (BKV) has been over half century, The previous epidemiological and phylogenetic studies suggest that BKV prevailed and co-evolved with humans, leading to high seroprevalence all over the world.
Xianfeng Zhou +4 more
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Current In Vitro Models to Study Varicella Zoster Virus Latency and Reactivation
Viruses, 2019 Varicella zoster virus (VZV) is a highly prevalent human pathogen that causes varicella (chicken pox) during primary infection and establishes latency in peripheral neurons.
Abel Viejo-Borbolla +2 more
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HSV-1 reactivation as an emergent property of neuronal stress: implications for traumatic brain injury [PDF]
Journal of NeuroinflammationHerpes simplex virus type 1 (HSV-1) establishes lifelong latency in neurons, with reactivation driven by multiple molecular, cellular, and systemic stressors.
Alyson R. Stewart +5 more
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A Virally Encoded DeSUMOylase Activity Is Required for Cytomegalovirus Reactivation from Latency
Cell Reports, 2018 Summary: A subset of viral genes is required for the long-term latent infection of hematopoietic cells by human cytomegalovirus (HCMV). Here, we show that a latency-associated gene product (LUNA) promotes the disruption of cellular PML bodies during ...
Thomas Stamminger +2 more
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The human cytomegalovirus chemokine binding protein UL22A is necessary for efficient reactivation from latency in CD34+ hematopoietic progenitor cells and humanized mice [PDF]
Journal of VirologyHerpesviruses and poxviruses encode secreted chemokine binding proteins that prevent the interaction between chemokines and their cognate G protein-coupled receptors to alter chemotactic gradients and intracellular signaling pathways.
Rebekah L. Turner +14 more
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Regulation of herpes simplex virus type 1 latency-reactivation cycle and ocular disease by cellular signaling pathways [PDF]
Experimental Eye Research, 2022 Clinton Jones, Kelly Harrison
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