Results 41 to 50 of about 71,076 (242)

Interferon beta drives therapy resistance in a patient‐derived model of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Interferon type 1 (IFN‐1) production and signaling is associated with the acquisition of therapy resistance, following chronic DNA damage, via Interferon‐related DNA damage resistance signature (IRDS) gene expression. An alternative, DNA damage‐independent role of sustained IFN‐1 mediated resistance was identified and characterized by the emergence of ...
Ashlyn Conant, Tise Suzuki, Kiera McGivney, V. S. S. Abhinav Ayyadevara, Sharon Asariah, Jay Deng, Ethan Nyein, Jacqueline Coats, Gary Yu, Yevgeniya J. Ioffe, Christian Hurtz, Juli J. Unternaehrer   +11 more
wiley   +1 more source

ADP‐ribosylation: An emerging regulator of the epigenome

Molecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho, Chenqian Liu, W. Lee Kraus   +2 more
wiley   +1 more source

Early‐life high‐fat diet exposure increases Achilles tendon stiffness and induces transcriptomic alterations

FEBS Open Bio, EarlyView.
Early‐life exposure to a high‐fat diet altered intact Achilles tendons in rat offspring, making them thinner, stiffer, and molecularly distinct even without injury. These findings suggest that developmental high‐fat diet exposure may impair tendon quality and increase susceptibility to mechanical overload or tendon injury later in life.
Heyong Yin, Ziyang Yuan, Wenli Jiang, Ai Guo   +3 more
wiley   +1 more source

A Latent Transition Analysis Model for Assessing Change in Cognitive Skills [PDF]

Educational and Psychological Measurement, 2015
Latent transition analysis (LTA) was initially developed to provide a means of measuring change in dynamic latent variables. In this article, we illustrate the use of a cognitive diagnostic model, the DINA model, as the measurement model in a LTA, thereby demonstrating a means of analyzing change in cognitive skills over time.
Feiming, Li, Allan, Cohen, Brian, Bottge, Jonathan, Templin   +3 more
openaire   +2 more sources

Dose‐dependent hepatotoxicity of hydrogen peroxide in HepG2 cells and its modulation by CYP450 induction

FEBS Open Bio, EarlyView.
NMR metabolomics revealed concentration‐dependent metabolic perturbations in HepG2 cells exposed to H2O2. Rifampicin pretreatment enhanced metabolic competence, attenuated toxin‐induced alterations and produced metabolite profiles more consistent with human liver physiology, supporting the use of CYP450‐induced HepG2 models for improved in vitro ...
Maren Jinks, Garth L. Maker, Emily C. Davies, Berin A. Boughton, Samantha Lodge   +4 more
wiley   +1 more source

The mediating role of biological age in the impact of mood instability symptoms on neurodegenerative disease and mortality

BMC Medicine
Background Accumulating evidence links mood instability to an increased risk of adverse outcomes, yet its relationship with neurodegenerative diseases remains underexplored.
Junru Wang, Jiahui Zhang, Kai Liu, Jing Wang, Yali Wang, Xiaojun Ma, Zhuoyuan Li, Shulan He, Xiaojuan Liu, Ping Chen, Jiangping Li   +10 more
doaj   +1 more source

Emotion regulation profiles across time: a latent transition analysis

International Journal of Adolescence and Youth
Difficulties in emotion regulation are associated with mental health problems during adolescence. This study aimed to identify distinct emotion regulation profiles in adolescents, examine potential differences between profiles, and examine transitions ...
Hedvig Andersson, Berit Gustafsson, Erik Aspeqvist, Reeta Kankaanpää, Laura Korhonen, Maria Zetterqvist   +5 more
doaj   +1 more source

Anticipatory emotions at the prospect of the transition to higher education: A latent transition analysis

Journal of Vocational Behavior, 2021
Abstract While some attention has been devoted to the study of emotions in vocational psychology, research on the emotional anticipation of future career events is scarce. Using latent transition analysis, we investigated profiles of anticipatory emotions at the prospect of the transition to higher education during the last year of high school.
Parmentier, Michaël, Dangoisse, Florence, Zacher, Hannes, Pirsoul, Thomas, Nils, Frédéric   +4 more
openaire   +1 more source

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

Aging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang, Zhong Fan, Runmeng Liu, Xiaotian Zhang   +3 more
wiley   +1 more source

The development of mathematics expectancy-value profiles during the secondary–tertiary transition into STEM fields

International Journal of STEM Education
Background To master the secondary–tertiary transition into fields of science, technology, engineering, and mathematics (STEM), academic self-beliefs play a pivotal role, especially those related to learning mathematics. The framework of expectancy-value
Martin Mayerhofer, Marko Lüftenegger, Michael Eichmair   +2 more
doaj   +1 more source