Results 41 to 50 of about 1,677,295 (274)

Clinical feasibility of endoscopic submucosal dissection with minimum lateral margin of superficial esophageal squamous cell carcinoma

Endoscopy International Open, 2019
Background Esophageal stricture following endoscopic submucosal dissection (ESD) for superficial esophageal squamous cell cancer (SESCC) has been associated with wide mucosal defects greater than three-quarters of the luminal circumference. Some patients
Hiroki Kuwabara, Seiichiro Abe, Satoru Nonaka, Haruhisa Suzuki, Shigetaka Yoshinaga, Ichiro Oda, Yutaka Saito   +6 more
doaj   +1 more source

Effects of Dry Granulation Operating Parameters on Forming Quality

Applied Sciences, 2023
To address the issues of the existing dry granulation process, which mostly relies on manual adjustments based on empirical experience and lacks the analysis of theoretical data, a simplified model of tablet pressing based on a modified Drucker–Prager ...
Xiaowen Xie, Haozheng Gao, Zhongze Xie, Mingge Wu   +3 more
doaj   +1 more source

The heat shock response plays an important role in TDP-43 clearance: evidence for dysfunction in amyotrophic lateral sclerosis

Brain : a journal of neurology, 2016
Insoluble TDP-43 inclusions are the pathological hallmark of ALS and tau-negative frontotemporal lobar degeneration. Chen et al. show that the heat shock response (HSR), which regulates chaperone expression, is compromised in an ALS mouse model and in ...
Han-Jou Chen, Jacqueline C Mitchell, S. Novoselov, Jack W. Miller, A. Nishimura, E. Scotter, C. Vance, M. Cheetham, C. Shaw   +8 more
semanticscholar   +1 more source

The Role of VCP Mutations in the Spectrum of Amyotrophic Lateral Sclerosis—Frontotemporal Dementia

Frontiers in Neurology, 2022
Amyotrophic Lateral Sclerosis (ALS) and Frontotemporal Dementia (FTD) are two neurological diseases which, respectively, and primarily affect motor neurons and frontotemporal lobes.
E. Scarian, G. Fiamingo, L. Diamanti, Ilaria Palmieri, S. Gagliardi, O. Pansarasa   +5 more
semanticscholar   +1 more source

Impaired glymphatic function in the early stages of disease in a TDP-43 mouse model of amyotrophic lateral sclerosis

Translational Neurodegeneration, 2022
Background Multiple lines of evidence suggest possible impairment of the glymphatic system in amyotrophic lateral sclerosis (ALS). To investigate this, we used in vivo magnetic resonance imaging (MRI) to assess glymphatic function early in the course of ...
Akram Zamani, A. Walker, B. Rollo, K. Ayers, Raysha Farah, T. O’Brien, David K. Wright   +6 more
semanticscholar   +1 more source

Lateral Rhinotomy for a Large, Infected Haller Cell Causing Proptosis

Philippine Journal of Otolaryngology Head and Neck Surgery, 2018
Objective: To report a case of a large sinus Haller cell that presented with chronic rhinosinusitis and proptosis and its surgical management. Method:             Design:            Case Report             Setting:            Tertiary Government
Debangshu Ghosh, Dilip Kumar Baruah, Subodh Chandra Goswmi, Sumit Kumar Basu   +3 more
doaj   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Research on AH-model Vehicle Clearance Based on Dynamics Simulation Calculation

Chengshi guidao jiaotong yanjiu
Objective The AH-model vehicle combines the characteristics of A and B type model vehicles. Due to its structural differences from conventional metro vehicles, there are currently no corresponding standards on vehicle clearance in China at present, thus ...
MEN Yonglin, ZHANG Yunhang, XU Xu
doaj   +1 more source

USP10 Inhibits Aberrant Cytoplasmic Aggregation of TDP-43 by Promoting Stress Granule Clearance

Molecular and Cellular Biology, 2022
TAR DNA-binding protein 43 (TDP-43) is a causative factor of amyotrophic lateral sclerosis (ALS). Cytoplasmic TDP-43 aggregates in neurons are a hallmark pathology of ALS.
Masahiko Takahashi, H. Kitaura, A. Kakita, T. Kakihana, Y. Katsuragi, O. Onodera, Y. Iwakura, H. Nawa, M. Komatsu, M. Fujii   +9 more
semanticscholar   +1 more source