Results 51 to 60 of about 102,219 (300)
Virus Detection by CRISPR-Cas9-Mediated Strand Displacement in a Lateral Flow Assay. [PDF]
ACS Appl Bio MaterIn public health emergencies or in resource-constrained settings, laboratory-based diagnostic methods, such as RT-qPCR, need to be complemented with accurate, rapid, and accessible approaches to increase testing capacity, as this will translate into ...
Montagud-Martínez R +7 more
europepmc +2 more sources
A point-of-care lateral flow assay for neutralising antibodies against SARS-CoV-2
EBioMedicine, 2021 Background: As vaccines against SARS-CoV-2 are now being rolled out, a better understanding of immunity to the virus, whether from infection, or passive or active immunisation, and the durability of this protection is required. This will benefit from the
Thomas S. Fulford +32 more
doaj +1 more source
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Assay sensitivity of the top 4 mAb pairs (LcrV or F1) by lateral flow immunoassay.
, 2022 Assay sensitivity of the top 4 mAb pairs (LcrV or F1) by lateral flow immunoassay.
Haley L. DeMers (9596353) +17 more
core +1 more source
Lateral flow assays: Principles, designs and labels
TrAC Trends in Analytical Chemistry, 2016 Abstract Lateral flow assays (LFAs) have attracted interest due to their friendly user formats, short assay times, little interferences, low costs, and being easy by operated by non-specialized personnel. This technique is based on biochemical interaction of antigen-antibody or probe DNA-target DNA hybridization.
Bahadir, Elif Burcu +1 more
openaire +3 more sources
mSphereNucleic acid amplification testing (NAAT) for N. gonorrhoeae is unavailable in resource-limited settings. We previously developed a CRISPR-based lateral flow assay for detecting N. gonorrhoeae.
Lao-Tzu Allan-Blitz +10 more
doaj +1 more source
Clinical Performance of Lateral Flow Assay for Cryptosporidium spp. Diagnosis
Biomedicines, 2023 Cryptosporidium spp. is an apicomplexan protozoan parasite associated with gastroenteritis in humans. In 2018, Spain showed 1511 confirmed cases, with a growing trend since 2014. Despite this fact, Cryptosporidium spp.
Miriam Campos-Ruiz +7 more
doaj +1 more source
Molecular Oncology, EarlyView.Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau +8 more
wiley +1 more source
Lateral flow assay for detection and recovery of live cell Neisseria gonorrhoeae
Current Research in Biotechnology, 2022 Gonorrhea, caused by Neisseria gonorrhoeae, is a global disease that disproportionately impacts low- and middle-income countries. Current testing methods have failed to significantly reduce disease burden, thereby allowing untreated gonorrhea infections ...
Taylor Oeschger +2 more
doaj +1 more source