Results 281 to 290 of about 219,064 (327)

Multiscale Organization of Neural Networks in a 3D Bioprinted Matrix

Advanced Science, EarlyView.
A 3D bioprint model of primary neurons has been engineered with a millimeter‐scale functional neural network, and it recapitulates in vivo transcriptomic features under both normal and disease conditions to the greatest extent. The successful integration of mature neurons and 3D bioprinting signifies a major advance in neuroscience modeling ...
Huiyu Yang, Jiangang Zhang, Yiran Li, Zihan Zhong, Wenhua Li, Haojun Luo, Yanyong Liu, Liujian Ouyang, Zhuoran Jiang, Yuning Sun, Hang Sun, Lulu Liu, Huayu Yang, Yu Wang, Nan Yang, Wenbin Ma, Yilei Mao   +16 more
wiley   +1 more source

Visualization of the Spiral Ganglion Neuron in Vivo Using a Novel 177Lu Nuclear Molecule Label

Advanced Science, EarlyView.
The study developed and validated a radionuclide‐labeled anti‐VGLUT1 antibody probe for the first nuclear imaging of cochlear spiral ganglion neurons (SGNs) in vivo. This approach may provide aid in screening candidates suitable for CI surgery by quantifying the number of surviving SGNs, and predicting the potential for postoperative hearing ...
Chenyang Kong, Xiaohui Wang, Jintao Yu, Li Wen, Chengwen Zheng, Ge Yin, Kai Xu, Weiwei He, Hao Wang, Xiaoli Lan, Dawei Jiang, Yu Sun   +11 more
wiley   +1 more source

Engineering Liquid Hierarchical Materials with DNA‐Programmed Spherical Nucleic Acids

Advanced Science, EarlyView.
Programmable spherical nucleic acids assembly strategies for constructing hierarchical structures through engineered DNA bond to form novel liquid‐like metal droplets. Abstract Inspired by nature, the orchestration of self‐assembling building blocks into hierarchical superstructures offers a transformative approach to functional materials design. While 
Zeyu Chen, Xu Chen, Dan Lu, Huating Kong, Jingyi Ye, Chunhai Fan, Honglu Zhang, Huan Zhang   +7 more
wiley   +1 more source

Exotropia in a Patient With a Novel Homozygous 4-Hydroxyphenylpyruvate Dioxygenase-Like Protein (HPDL) Variant. [PDF]

Cureus
Kasuya Y, Mitani T, Noguchi K, Mizuno T, Makino S, Osaka H.   +5 more
europepmc   +1 more source

A Feedback Loop Between Fatty Acid Metabolism and Epigenetics in Clear Cell Renal Carcinoma

Advanced Science, EarlyView.
The current study has profiled the landscape of active enhancers in ccRCC and identified FABP5 as an oncogene. FABP5 is essential for the lipid droplet formation driven by HIFs and critical for H3K27ac and enhancer activity. The study has discovered the function of a feedback loop between epigenetics and lipid metabolism regulated by FABP5 in ccRCC ...
Zhou Ye, Qi‐Xin Hu, Ming‐Liang Wei, Ji‐Dong Chen, Jia Shi, Ning‐Rong Yang, Lu Jiang, Jian Chen, Zhi‐Yuan Chen, Wei‐Min Yu, Yu Xiao, Kai‐Yu Qian, Zilin Xu, Zhong Wang, Wen‐Lu Qi, Xin‐Yi Xiao, Yu‐Yu Duan, Yong Xiao, Lian‐Yun Li, Lin‐Gao Ju, Ming‐Kai Chen, Min Wu   +21 more
wiley   +1 more source

Rampant Interkingdom Horizontal Gene Transfer in Pezizomycotina? An Updated Inspection of Anomalous Phylogenies. [PDF]

Int J Mol Sci
Aguirre-Carvajal K, Cárdenas S, Munteanu CR, Armijos-Jaramillo V.   +3 more
europepmc   +1 more source

Role of Lysogenic Phages in the Dissemination of Antibiotic Resistance Genes Applied in the Food Chain. [PDF]

Foods
Cadamuro RD, Elois MA, Pilati GVT, Savi BP, Pessi L, Jempierre YFSH, Rodríguez-Lázaro D, Fongaro G.   +7 more
europepmc   +1 more source

Phylogenetic reconstruction and lateral gene transfer [PDF]

Trends in Microbiology, 2004
Lateral gene transfer (LGT) is often seen as a form of noise, obscuring the phylogenetic signal with which we might hope to reconstruct the evolution of a group of organisms, or indeed the history of all life (the Tree of Life). Such reconstruction might still be possible if the subset of genes conserved among all genomes in a group (or common to all ...
Jessica W. Leigh, Eric Bapteste, W. Ford Doolittle, Yan Boucher   +3 more
openaire   +2 more sources

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Lateral gene transfer in Salmonella

Microbes and Infection, 2003
Comparative genomics and microarrays reveal that the genomes of different Salmonella enterica serovars are distinguished from each other by the presence or absence of hundreds of genes. The distribution of these variable genome regions is often not clonal.
Michael McClelland, Steffen Porwollik
openaire   +3 more sources

Detecting Laterally Transferred Genes

2012
Methods for identifying alien genes in genomes fall into two general classes. Phylogenetic methods examine the distribution of a gene's homologues among genomes to find those with relationships not consistent with vertical inheritance. These approaches include identifying orphan genes which lack homologues in closely related genomes and genes with ...
Rajeev K. Azad, Rajeev K. Azad, Jeffrey G. Lawrence   +2 more
openaire   +3 more sources