Results 41 to 50 of about 3,156,191 (292)

Field studies on the effects of under sleeper pads in lateral resistance of railway [PDF]

Journal of Structural and Construction Engineering, 2016
Under sleeper pads are used in several areas, specially, in places where transfer of vibrations to the surrounding areas should be limited. Beside of all advantages of this elements in the field of reducing costs of repair and maintenance of railway ...
Armin Monir Abbasi, Esmail Shahrokhinasab, Jabbar Ali Zakeri   +2 more
doaj  

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Lateral transfer and GC content of bacterial resistant genes [PDF]

Frontiers in Microbiology, 2013
Lateral genetic transfer (LGT) is one of the ways in which microorganisms such as bacteria could move and rearrange genetic materials from and into their genomes (Ragan and Beiko, 2009). The dissemination of antibiotic resistance genes between two microorganisms or between a microorganism and the environment could occur, for example, by conjugation ...
openaire   +3 more sources

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Design of a new high lateral resistance sleeper and performance comparison with conventional sleepers in a curved railway track by means of finite element models

Latin American Journal of Solids and Structures
The lack of lateral resistance in a curved railway track can produce misalignment problems due to the centrifugal forces when the trains pass through. Moreover, most of the times continuous welded rails (CWR) are used in nowadays railway tracks, which ...
Laura Montalbán Domingo, Julia I. Real Herraiz, Clara Zamorano, Teresa Real Herraiz   +3 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Analysis of electrical properties in lateral Schottky barrier diode based on n-GaN and AlGaN/GaN heterostructure

Frontiers in Physics, 2022
In this paper, the lateral Schottky barrier diodes (SBDs) with small capacitance and low turn-on voltage (Von) were fabricated on n-GaN and AlGaN/GaN heterostructure. The capacitances of lateral n-GaN SBD and lateral AlGaN/GaN SBD are 1.35 pF/mm and 0.70 
Honghui Liu, Zhiwen Liang, Fengge Wang, Yanyan Xu, Xien Yang, Yisheng Liang, Xin Li, Lizhang Lin, Zhisheng Wu, Yang Liu, Baijun Zhang   +10 more
doaj   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Bearing characteristics of ultra-long piles based on distributed fiber optic sensing technology

Yantu gongcheng xuebao
Based on a series of pile foundation tests from a project in the Super Headquarters Base in Shenzhen Bay, the load deformation characteristics of super-long piles under different geological conditions and the impact of friction coefficient on pile-soil ...
FU Zhangxin 1, CAO Wenzhao 1, 2, WU Xujun 1, 2, ZHANG Xingjie 2, LUO Muchi 1
doaj   +1 more source

Experimental study of trench effect on lateral failure mechanisms around the pipeline buried in clay

Journal of Pipeline Science and Engineering, 2021
Pipelines are usually trenched and backfilled using the pre-excavated soil as cost-effective protection against the environmental, constructional, and operational loads.
Morteza Kianian, Hodjat Shiri
doaj   +1 more source