Results 41 to 50 of about 248,657 (265)

Bearing characteristics of ultra-long piles based on distributed fiber optic sensing technology

Yantu gongcheng xuebao
Based on a series of pile foundation tests from a project in the Super Headquarters Base in Shenzhen Bay, the load deformation characteristics of super-long piles under different geological conditions and the impact of friction coefficient on pile-soil ...
FU Zhangxin 1, CAO Wenzhao 1, 2, WU Xujun 1, 2, ZHANG Xingjie 2, LUO Muchi 1
doaj   +1 more source

Experimental study of trench effect on lateral failure mechanisms around the pipeline buried in clay

Journal of Pipeline Science and Engineering, 2021
Pipelines are usually trenched and backfilled using the pre-excavated soil as cost-effective protection against the environmental, constructional, and operational loads.
Morteza Kianian, Hodjat Shiri
doaj   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Lateral migration resistance of screw is essential in evaluating bone screw stability of plate fixation

Scientific Reports, 2021
Conventional evaluation of the stability of bone screws focuses on pullout strength, while neglecting lateral migration resistance. We measured pullout strength and lateral migration resistance of bone screws and determined how these characteristics ...
Xiaoreng Feng, Weichen Qi, Teng Zhang, Christian Fang, Hongfeng Liang, Bin Chen, Frankie Leung   +6 more
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Differential microbiological spectrum and resistance pattern in periprosthetic hip joint infections: a matched-cohort analysis comparing direct anterior versus lateral approach

BMC Musculoskeletal Disorders, 2022
Background In recent years, total hip arthroplasty via the direct anterior approach (DAA) has become more common. Little is known on the influence of the surgical approach on the microbiological spectrum and resistance pattern in periprosthetic hip joint
Alexander Aichmair, Bernhard J. H. Frank, Gabriel Singer, Sebastian Simon, Martin Dominkus, Jochen G. Hofstaetter   +5 more
doaj   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Ballast bed resistance characteristics based on discrete-element modeling

Advances in Mechanical Engineering, 2018
In this study, in situ experiments were conducted to study the changing characteristics of the lateral and longitudinal resistance of a ballast bed, and a three-dimensional model for the ballast bed and sleeper was constructed based on the discrete ...
Zhiping Zeng, Shanyi Song, Weidong Wang, Haijian Yan, Guoshu Wang, Bin Xiao   +5 more
doaj   +1 more source

Early‐life high‐fat diet exposure increases Achilles tendon stiffness and induces transcriptomic alterations

FEBS Open Bio, EarlyView.
Early‐life exposure to a high‐fat diet altered intact Achilles tendons in rat offspring, making them thinner, stiffer, and molecularly distinct even without injury. These findings suggest that developmental high‐fat diet exposure may impair tendon quality and increase susceptibility to mechanical overload or tendon injury later in life.
Heyong Yin, Ziyang Yuan, Wenli Jiang, Ai Guo   +3 more
wiley   +1 more source

Effect of the Particle Size Distribution of the Ballast on the Lateral Resistance of Continuously Welded Rail Tracks

Infrastructures
While the effect of ballast degradation on lateral resistance is noteworthy, limited research has delved into the specific aspect of ballast breakage in this context.
Jafar Chalabii, Morteza Esmaeili, Dániel Gosztola, Szabolcs Fischer, Majid Movahedi Rad   +4 more
doaj   +1 more source