Results 61 to 70 of about 5,030,269 (303)

Salmonella lipopolysaccharide‐containing supported lipid bilayers as platforms to study bacteriophage interactions

open access: yesFEBS Letters, EarlyView.
We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace   +6 more
wiley   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

open access: yesFEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj   +3 more
wiley   +1 more source

Research on Lateral Load Bearing Characteristics of Deepwater Drilling Conductor Suction Pile

open access: yesEnergies
The vast reserves of natural gas hydrates in offshore areas present significant challenges to development. Surface well construction technology is crucial for the extraction of deepwater natural gas hydrates.
Shuzhan Li   +5 more
doaj   +1 more source

Analysis of vehicle lateral stability estimating suspension characteristics on the snowy and dry road / Automobilio skersinio stovumo analizė vertinant pakabos charakteristikas važiuojant snieguota ir sausa kelio danga

open access: yesMokslas: Lietuvos Ateitis, 2013
This paper analyzes the lateral dynamics of the vehicle withindependent suspension. The tests have been made driving inan incremental acceleration mode under conditions of a circulartrajectory within 10, 15 and 20-meter radius.
Vidas Žuraulis   +2 more
doaj   +1 more source

Rear-Wheel Steering Control for Enhanced Steady-State and Transient Vehicle Handling Characteristics

open access: yesIEEE Access, 2020
This paper presents a rear-wheel steering (RWS) control algorithm to enhance the vehicle handling performance without prior knowledge of tire characteristics.
Kwanwoo Park   +3 more
doaj   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

open access: yesFEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang   +4 more
wiley   +1 more source

Freight car model with Y25 bogies stability analysis

open access: yesPojazdy Szynowe, 2023
Y25 (25Tn) bogies have been used in freight cars for over 50 years. It is a proven design with a positive opinion in many European countries. In addition to the generally positive opinion about the operational properties of the Y25 bogies, there are ...
Mirosław Dusza
doaj   +1 more source

Structure‐forward targeting of claudins with synthetic binders

open access: yesFEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Lateral-Stability-Oriented Path-Tracking Control Design for Four-Wheel Independent Drive Autonomous Vehicles with Tire Dynamic Characteristics under Extreme Conditions

open access: yesWorld Electric Vehicle Journal
This paper proposes a lateral-stability-oriented path-tracking controller for four-wheel independent drive (4WID) autonomous vehicles. The proposed controller aims to maintain vehicle stability under extreme conditions while minimizing lateral deviation.
Zhencheng Yu   +2 more
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

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