Results 91 to 100 of about 25,828 (235)

Epigenetic Regulation of Liver Fibrosis: Mechanisms and Therapeutic Implications

Portal Hypertension &Cirrhosis, EarlyView.
This review synthesizes the epigenetic mechanisms—DNA methylation, histone modifications, and non‐coding RNAs—that drive hepatic stellate cell activation and the progression of liver fibrosis. It further evaluates emerging therapeutic strategies targeting these epigenetic regulators, including DNA methyltransferase and histone deacetylase inhibitors ...
Maryam Jadid Tavaf, Mahboobeh Ebrahimi Varkiani, Saeid Abroun, Pedram Asadi‐Sarabi, Shukoofeh Torabi, Elham Rismani, Mohammad Majd Hammour, Andreas K. Nüssler, Massoud Vosough   +8 more
wiley   +1 more source

Preparation regimen is more important than patient-related factors: a randomized trial comparing a standard bowel preparation before colonoscopy with an individualized approach

Romanian Journal of Internal Medicine, 2017
Background. Optimal bowel preparation is one of the most important factors affecting the quality of colonoscopy. Several patient-related factors are known to influence the quality of bowel cleansing but randomized trials in this area are lacking.
Voiosu T., Tanţău Alina, Voiosu A., Benguş Andreea, Mocanu Cristina, Smarandache Bianca, Baicuş C., Vişovan Ioana, Mateescu B.   +8 more
doaj   +1 more source

A Systematic Scoping Review of Participant Descriptor, Diversity and Inclusivity Data Reported in Randomised Studies of Post‐Operative Ileus

ANZ Journal of Surgery, EarlyView.
ABSTRACT Background Poor reporting of baseline descriptor, diversity and inclusion data is a barrier in surgical research for drawing generalisable conclusions across diverse populations. Post‐operative ileus was used as an exemplar surgical condition to quantify the variation in baseline descriptor, inclusivity and diversity data in randomised ...
Miriam Khalil, Edward Roberts, David G. Jayne, Stephen J. Chapman   +3 more
wiley   +1 more source

Negative effects of abuse of laxatives in medical practice

, 2018
The abuse of laxatives is a disorder characterized by an incomprehensible and changing range of gastrointestinal, electrolytic and acid-base abnormalities that can lead to both the onset of chronic diseases and fatalities.
Yu.M. Stepanov, M.V. Stoikevych, O.N. Vlasova   +2 more
core   +1 more source

Changes in Gastrointestinal Symptoms Among Children With Cystic Fibrosis During 12 Months of Elexacaftor/Tezacaftor/Ivacaftor Therapy: A Swedish Multicentre Study

Acta Paediatrica, EarlyView.
ABSTRACT Aim Elexacaftor/Tezacaftor/Ivacaftor (ETI) has markedly improved clinical outcomes in cystic fibrosis (CF). However, its effects on gastrointestinal (GI) function, nutrition and pancreatic enzyme therapy in children remain insufficiently described.
Marcus Svedberg, Ellen Karlge Nilsson, Per Ekman, Henrik Imberg   +3 more
wiley   +1 more source

Colonoscopic Resolution of Melanosis Coli After Cessation of Senna Laxative Use

International Medical Case Reports Journal
Toshimi Chiba,1,* Ting Wang,1,* Satoshi Kikuchi2,* 1Division of Internal Medicine, Department of Oral Medicine, Iwate Medical University, Morioka, Iwate, Japan; 2Department of Gastroenterology, Sanai Hospital, Morioka, Iwate, Japan*These ...
Chiba T, Wang T, Kikuchi S
doaj  

Modern approaches to the treatment of constipation in pregnant women

Лечащий Врач
Background. Constipation, or constipation, is a polyetiological pathological condition characterized by prolongation of the intervals between acts of defecation and changes in the shape and consistency of fecal matter.
A. K. Minaeva
doaj   +1 more source

Gut microbiota as a novel therapeutic target for eating disorders and obesity

British Journal of Pharmacology, EarlyView.
The graphical abstract highlights the bidirectional interaction between the gut microbiota and central homeostatic and hedonic mechanisms regulating food intake, which contributes to overweight and obesity. It also illustrates emerging microbiota‐based biomarkers and therapeutic strategies (including prebiotics, probiotics, postbiotics, synbiotics and ...
Solveiga Samulėnaitė, Victor Mathis, Emmanuel Darcq, Aurelijus Burokas, Elena Martín‐García, Rafael Maldonado   +5 more
wiley   +1 more source

Surgical removal of a perirectal melanoma through sphincterotomy and rectal wall resection in a horse

Equine Veterinary Education, EarlyView.
Summary Melanomas are among the most frequent neoplasms in grey horses. Deep perirectal melanomas, however, are uncommon and challenging to excise due to their proximity to the peritoneal reflection. This report describes the successful standing removal of a large (16 × 8 × 6 cm) perirectal melanoma firmly adherent to the dorsal rectal wall in a 19 ...
R. Becker, C. Koch, M. de Preux
wiley   +1 more source

Effect of Cassia fistula L. aqueous extract in maternal reproductive outcome, some serum indices and fetal anomaly frequency in rat

Caspian Journal of Internal Medicine, 2022
Background: Cassia fistula was used traditionally as laxative in pregnant women. Nevertheless, its fetal and maternal effects in pregnancy have not been studied yet. Methods: Oral (Lethal Dose, 50%) LD50 was determined in mice.
Saeed Hakiminia, Zahra Esmaeeli, Ali Akbar Moghadamnia, Seyyed Gholam Ali Jorsaraei, Farideh Feizi, Sorayya Khafri, Zahra Memariani, Hoda Shirafkan, Seyyed Ali Mozaffarpur   +8 more
doaj