Organizing principles of cortical layer 6 [PDF]
Frontiers in Neural Circuits, 2010 Neurons in the deepest layer of mammalian cerebral cortex are morphologically and physiological diverse and are situated in a strategic position to modulate neuronal activity locally and in other structures. The variety of neuronal circuits within which
Farran Briggs
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Neocortical layer 6, a review [PDF]
Frontiers in Neuroanatomy, 2010 This review attempts to summarise some of the major areas of neocortical research as it pertains to layer 6. After a brief summary of the development of this intriguing layer, the major pyramidal cell classes to be found in layer 6 are described and ...
Alex M Thomson
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Rabies virus-based labeling of layer 6 corticothalamic neurons for two-photon imaging in vivo [PDF]
iScience, 2023 Summary: Neocortical layer 6 (L6) is less understood than other more superficial layers, largely owing to limitations of performing high-resolution investigations in vivo.
Miaoqing Gu +15 more
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Layer 6 ensembles can selectively regulate the behavioral impact and layer-specific representation of sensory deviants [PDF]
eLife, 2020 Predictive models can enhance the salience of unanticipated input. Here, we tested a key potential node in neocortical model formation in this process, layer (L) 6, using behavioral, electrophysiological and imaging methods in mouse primary somatosensory
Jakob Voigts +2 more
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Activation of Corticothalamic Layer 6 Cells Decreases Angular Tuning in Mouse Barrel Cortex [PDF]
Frontiers in Neural Circuits, 2019 In the mouse whisker system, the contribution of L6 corticothalamic cells (L6 CT) to cortical and thalamic processing of the whisker deflection direction was investigated. A genetically defined population of L6 CT cells project to infragranular GABAergic
François Philippe Pauzin +2 more
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Infrabarrels Are Layer 6 Circuit Modules in the Barrel Cortex that Link Long-Range Inputs and Outputs [PDF]
Cell Reports, 2017 The rodent somatosensory cortex includes well-defined examples of cortical columns—the barrel columns—that extend throughout the cortical depth and are defined by discrete clusters of neurons in layer 4 (L4) called barrels.
Shane R. Crandall +3 more
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Opposing Cholinergic and Serotonergic Modulation of Layer 6 in Prefrontal Cortex [PDF]
Frontiers in Neural Circuits, 2018 Prefrontal cortex is a hub for attention processing and receives abundant innervation from cholinergic and serotonergic afferents. A growing body of evidence suggests that acetylcholine (ACh) and serotonin (5-HT) have opposing influences on tasks ...
Daniel W. Sparks +7 more
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Layer 6 corticocortical neurons are a major route for intra- and interhemispheric feedback [PDF]
eLifeThe neocortex comprises anatomically discrete yet interconnected areas that are symmetrically located across the two hemispheres. Determining the logic of these macrocircuits is necessary for understanding high level brain function. Here in mice, we have
Simon Weiler +2 more
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An orexin-sensitive subpopulation of layer 6 neurons regulates cortical excitability and anxiety behaviour [PDF]
Translational PsychiatryCortical layer 6 neurons are the only projection neuron population in the cortical mantle known to electrophysiologically respond to orexin—a neuropeptide involved in cortical arousal and emotive behaviour.
Fernando Messore +11 more
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Cell-type-selective synaptogenesis during the development of layer 6 corticothalamic neuron connectivity in the mammalian neocortex [PDF]
Cell ReportsSummary: The function of the mammalian neocortex relies on the timing of axon extension and establishment of cell-type-biased patterns of excitatory synaptic connections.
Alan Y. Gutman-Wei +9 more
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