Results 1 to 10 of about 21,610 (241)

LC-HRMS Lipidomic Fingerprints in Serbian Cohort of Schizophrenia Patients. [PDF]

Int J Mol Sci
Schizophrenia (SCH) is a major mental illness that causes impaired cognitive function and long-term disability, so the requirements for reliable biomarkers for early diagnosis and therapy of SCH are essential. The objective of this work was an untargeted lipidomic study of serum samples from a Serbian cohort including 30 schizophrenia (SCH) patients ...
Marković S, Jadranin M, Miladinović Z, Gavrilović A, Avramović N, Takić M, Tasic L, Tešević V, Mandić B.   +8 more
europepmc   +5 more sources

Prioritization of Unknown LC-HRMS Features Based on Predicted Toxicity Categories. [PDF]

Environ Sci Technol
Complex environmental samples contain a diverse array of known and unknown constituents. While liquid chromatography coupled with high-resolution mass spectrometry (LC-HRMS) nontargeted analysis (NTA) has emerged as an essential tool for the comprehensive study of such samples, the identification of individual constituents remains a significant ...
Turkina V, Gringhuis JT, Boot S, Petrignani A, Corthals G, Praetorius A, O'Brien JW, Samanipour S.   +7 more
europepmc   +3 more sources

Validation of an LC–HRMS Method for Quantifying Indoxyl Sulfate and p-Cresyl Sulfate in Human Serum [PDF]

Molecules
Accurate quantification of indoxyl sulfate (IndS) and p-cresyl sulfate (pCS) is essential for understanding their role in chronic kidney disease (CKD) progression and for developing strategies to mitigate their harmful effects, including cardiovascular ...
María Rodríguez-García, Irene Martínez, Irene Aliart, Jaime I. Sainz de Medrano, Nayra Rico, Víctor Joaquín Escudero-Saiz, Francisco Maduell, Manuel Morales-Ruiz, Gregori Casals   +8 more
doaj   +2 more sources

Therapeutic drug monitoring of selumetinib in pediatrics: a combined LC-MS/MS and LC-HRMS approach [PDF]

Frontiers in Pharmacology
Neurofibromatosis type 1 (NF1) is a genetic disorder characterized by the development of plexiform neurofibromas (PNs), benign yet potentially debilitating tumors with limited treatment options. Selumetinib, a selective MEK1/2 inhibitor, has emerged as a
Alessia Cafaro, Andrea Santangelo, Andrea Santangelo, Sebastiano Barco, Corinna Corsini, Roberto Bandettini, Pasquale Striano, Pasquale Striano, Maria Cristina Diana, Giuliana Cangemi   +9 more
doaj   +2 more sources

What is in the fish? Collaborative trial in suspect and non-target screening of organic micropollutants using LC- and GC-HRMS

Environment International, 2023
A collaborative trial involving 16 participants from nine European countries was conducted within the NORMAN network in efforts to harmonise suspect and non-target screening of environmental contaminants in whole fish samples of bream (Abramis brama ...
Wiebke Dürig, Sofia Lindblad, Oksana Golovko, Georgios Gkotsis, Reza Aalizadeh, Maria-Christina Nika, Nikolaos Thomaidis, Nikiforos A. Alygizakis, Merle Plassmann, Peter Haglund, Qiuguo Fu, Juliane Hollender, Jade Chaker, Arthur David, Uwe Kunkel, André Macherius, Lidia Belova, Giulia Poma, Hugues Preud'Homme, Catherine Munschy, Yann Aminot, Carsten Jaeger, Jan Lisec, Martin Hansen, Katrin Vorkamp, Linyan Zhu, Francesca Cappelli, Claudio Roscioli, Sara Valsecchi, Renzo Bagnati, Belén González, Ailette Prieto, Olatz Zuloaga, Ruben Gil-Solsona, Pablo Gago-Ferrero, Sara Rodriguez-Mozaz, Hélène Budzinski, Marie-Helene Devier, Georg Dierkes, Lise Boulard, Griet Jacobs, Stefan Voorspoels, Heinz Rüdel, Lutz Ahrens   +43 more
doaj   +1 more source

Measurement of Plasma Glucagon Levels Using Mass Spectrometry in Patients with Type 2 Diabetes on Maintenance Hemodialysis

Kidney & Blood Pressure Research, 2021
Background: Recently, attention has been focused on the effect of glucagon on blood glucose variability. The dynamics of glucagon have attracted attention as a new target in the treatment of diabetes patients.
Yuta Yoshizawa, Michihiro Hosojima, Hideyuki Kabasawa, Naohito Tanabe, Atsushi Miyachi, Hitoshi Hamajima, Eri Mieno, Masaki Kobayashi, Tadahiro Kitamura, Ichiei Narita, Akihiko Saito   +10 more
doaj   +1 more source

Multiplex Detection of 24 Staphylococcal Enterotoxins in Culture Supernatant Using Liquid Chromatography Coupled to High-Resolution Mass Spectrometry

Toxins, 2022
Staphylococcal food poisoning outbreaks are caused by the ingestion of food contaminated with staphylococcal enterotoxins (SEs). Among the 27 SEs described in the literature to date, only a few can be detected using immuno-enzymatic-based methods that ...
Donatien Lefebvre, Kevin Blanco-Valle, Jacques-Antoine Hennekinne, Stéphanie Simon, François Fenaille, François Becher, Yacine Nia   +6 more
doaj   +1 more source

Non-targeted analysis of unexpected food contaminants using LC-HRMS [PDF]

Analytical and Bioanalytical Chemistry, 2018
A non-target analysis method for unexpected contaminants in food is described. Many current methods referred to as "non-target" are capable of detecting hundreds or even thousands of contaminants. However, they will typically still miss all other possible contaminants. Instead, a metabolomics approach might be used to obtain "true non-target" analysis.
Kunzelmann, Marco, Winter, Martin, Åberg, Magnus, Hellenäs, Karl-Erik, Rosén, Johan   +4 more
openaire   +2 more sources

Ammonium Fluoride as Suitable Additive for HILIC-Based LC-HRMS Metabolomics [PDF]

Metabolites, 2019
Hydrophilic Interaction Liquid Chromatography (HILIC) chromatography is widely applied in metabolomics as a complementary strategy to reverse phase chromatography. Nevertheless, it still faces several issues in terms of peak shape and compounds ionization, limiting the automatic de-convolution and data semi-quantification performed through dedicated ...
Narduzzi, Luca, Royer, Anne-Lise, Bichon, Emmanuelle, Guitton, Yann, Le Bizec, Bruno, Buisson, Corinne, Dervilly, Gaud   +6 more
openaire   +5 more sources

Extending the Lipidome Coverage by Combining Different Mass Spectrometric Platforms: An Innovative Strategy to Answer Chemical Food Safety Issues

Foods, 2021
From a general public health perspective, a strategy combining non-targeted and targeted lipidomics MS-based approaches is proposed to identify disrupted patterns in serum lipidome upon growth promoter treatment in pigs.
Jérémy Marchand, Yann Guitton, Estelle Martineau, Anne-Lise Royer, David Balgoma, Bruno Le Bizec, Patrick Giraudeau, Gaud Dervilly   +7 more
doaj   +1 more source