LC-HRMS analysis of phospholipids bearing oxylipins [PDF]
Analytica Chimica ActaSeveral oxylipins including hydroxy- and epoxy-polyunsaturated fatty acids (PUFA) act as lipid mediators. In biological samples they dominantly occur esterified in phospholipids (PL).
Nadja, Kampschulte +4 more
core +3 more sources
Combining LC-HRMS and LC-HRMS/MS data to explore a cereal food processed under different conditions
International audienceCharacterizing the chemical fingerprint of a processed food is a major challenge to advance food quality. New untargeted approaches based on LC-HRMS analysis can unlock the potential to increase our understanding on how chemical ...
Camel, Valérie +5 more
core +6 more sources
Automated Near Real-Time QC for LC-HRMS. [PDF]
Rapid Commun Mass SpectromABSTRACT Rationale The quality of analytical measurements is typically evaluated after completion of the entire, or possibly multiple, measurement batch(es). Automated, near real‐time quality control (QC) during LC‐HRMS acquisition can prevent reruns and sample loss by flagging issues as they ...
Mohr MJ +6 more
europepmc +3 more sources
LC–HRMS determination of piperine on rat dried blood spots: A pharmacokinetic study
Journal of Pharmaceutical Analysis, 2016 A liquid chromatography–high resolution mass spectrometry (LC–HRMS) method was developed and validated for the determination of piperine (PPR) on dried blood spots (DBS).
Bokka Ramesh +5 more
doaj +3 more sources
Integrated 1D-LC-HRMS and Heart-Cutting 2D-LC-MS for Impurity Profiling and Chiral Separation of Mitiglinide Drug Substance. [PDF]
Rapid Commun Mass SpectromRationale The comprehensive quality control of chiral pharmaceuticals like mitiglinide necessitates simultaneous assessment of chemical impurities and enantiomeric purity, yet conventional workflows address these separately, leading ...
Wang C, Zhou S, Sun W, Pan Y, Feng H.
europepmc +2 more sources
Naive Bayes classification model for isotopologuedetection in LC-HRMS data [PDF]
Chemometrics and Intelligent Laboratory Systems, 2021 Isotopologue identification or removal is a necessary step to reduce the number of features that need to be identified in samples analyzed with non-targeted analysis. Currently available approaches rely on either predicted isotopic patterns or an arbitrary mass tolerance, requiring information on the molecular formula or instrumental error ...
Denice van Herwerden +5 more
openaire +6 more sources
LC-HRMS/MS-based phytochemical profiling of Piper spices: Global association of piperamides with endocannabinoid system modulation. [PDF]
, 2021 The plant genus Piper comprises extensively consumed spice taxa like black pepper (P. nigrum L.) or long pepper (P. longum L.). The chronic dietary use of different Piper spices has been associated with different health benefits, though the molecular ...
Gertsch, Jürg +3 more
core +1 more source
Characterization of an Amphetamine Interference from Gabapentin in an LC–HRMS Method [PDF]
Journal of Analytical Toxicology, 2019 Abstract An amphetamine interference was observed during the development of an liquid chromatography–high-resolution mass spectrometry (LC–HRMS) multi-class confirmation method for the determination of 47 drugs and metabolites in urine. The interference passed all qualitative criteria for amphetamine leading to potential false-positive ...
Ana Celia, Muñoz-Muñoz +5 more
openaire +2 more sources
Rapid and Reliable Data Treatment for the Control of Food Chemical Contaminants by LC-HRMS
, 2022 Liquid chromatography-high resolution mass spectrometry (LC-HRMS) is considered an unavoidable extension of low-resolution LC-MS/MS that stretches the capabilities of multi-residue analysis of chemical contaminants in food.
Thomas Bessaire (4867285) +4 more
core +1 more source
Ammonium Fluoride as Suitable Additive for HILIC-Based LC-HRMS Metabolomics [PDF]
Metabolites, 2019 Hydrophilic Interaction Liquid Chromatography (HILIC) chromatography is widely applied in metabolomics as a complementary strategy to reverse phase chromatography. Nevertheless, it still faces several issues in terms of peak shape and compounds ionization, limiting the automatic de-convolution and data semi-quantification performed through dedicated ...
Narduzzi, Luca +6 more
openaire +5 more sources