Quantitative Method for Analysis of Lipids by LC-HRMS and Fatty Acid Methyl Ester by GC-FID in Macauba (Acrocomia aculeata) Oils. [PDF]
Plants (Basel)Ferro EZS +3 more
europepmc +1 more source
Advanced Science, Volume 13, Issue 16, 18 March 2026.This study identifies a conserved CsdA‐LaeB hub in Aspergillus fumigatus that regulates secondary metabolite fumiquinazoline C (FqC). Disrupting this hub enhances FqC production and virulence, shedding new light on the post‐transcriptional regulatory logic linking secondary metabolism to pathogenicity and offering alternative strategies for diagnostic ...
Zili Song +14 more
wiley +1 more source
Trapped Ion Mobility Improves Annotation Accuracy in LC-HRMS Screening Applications for Exposomics. [PDF]
Anal ChemHuber C, Ulrich N, Krauss M.
europepmc +1 more source
AIE‐Active Cationic Tripyrrole Targeting Mitochondrial SDHAF1 for Acute Myeloid Leukemia Therapy
Aggregate, Volume 7, Issue 3, March 2026.Cationic tripyrrole oligomers (Tri‐DPPy) selectively accumulate in mitochondria and suppress Complex II activity by binding to SDHAF1, thereby effectively eradicating AML cells both in vitro and in vivo. ABSTRACT Therapy‐resistant acute myeloid leukemia (AML) depends on mitochondrial oxidative phosphorylation (OXPHOS) to meet its energy demands, and ...
Wangxing Lin +6 more
wiley +1 more source
Exploring non-target screening variability in unsupervised multivariate time trend analysis of LC-HRMS data. [PDF]
Anal Bioanal ChemArmin R, Vosough M, Schmidt TC.
europepmc +1 more source
Photo‐Catalyzed Labeling of Amyloid Deposits in Human Tissue to Proteotype Amyloidosis Diseases
Aggregate, Volume 7, Issue 3, March 2026.Amyloid‐ID, a ThT‐like photocatalytic probe, enables proteotyping of amyloid deposits by ROS‐mediated protein labeling. Applied to patient biopsies, amyloid‐ID identifies potential fibrinogen‐derived amyloid in laryngeal amyloidosis, revealing a mechanically sensitive fibrillation mechanism linked to vocal cord friction.
Huan Feng +10 more
wiley +1 more source
First Insights Into the LC-HRMS Profiling and Biological Activities of <i>Crocus graveolens</i>. [PDF]
Food Sci NutrErsoy E +5 more
europepmc +1 more source
Aggregate, Volume 7, Issue 3, March 2026.N‐oxide is a polar and multifunctional group. Herein, we report a new property of this versatile group that is structure‐dependent aggregation. The first‐generation application of this new finding is to design novel heme‐detecting probes. ABSTRACT N‐oxides, characterized by a highly polar N+–O− bond, have recently demonstrated rapidly growing ...
Si Ha +9 more
wiley +1 more source
Evaluation of Three Sample Preparation Methods for LC-HRMS Suspect Screening of Contaminants of Emerging Concern in Effluent Wastewater. [PDF]
Anal ChemOrlando-Véliz D +4 more
europepmc +1 more source
Archiv der Pharmazie, Volume 359, Issue 3, March 2026.A novel pyrazoline derivative (P2) was synthesized and demonstrated potent α‐glucosidase inhibition (IC50 = 2.10 µM), significantly surpassing acarbose and highlighting its promise as an effective oral antidiabetic agent. ABSTRACT This study reports the synthesis of some novel chalcone (C1–C3) and 3,5‐disubstituted pyrazoline derivatives (P1–P3 ...
Fatma Erbay +6 more
wiley +1 more source