Results 111 to 120 of about 255,317 (292)

A Novel Workflow for Fast Elucidation of Drug Metabolites for Screening—Combining In Silico Metabolite Prediction With Trapped Ion Mobility QTOF‐MS

Drug Testing and Analysis, EarlyView.
UHPLC‐timsTOF‐MS with in silico prediction and automated annotation enabled rapid identification of quetiapine metabolites from pHLMs, facilitating their inclusion in targeted LC‐QTOF‐MS urine screening and improving biomarker detection for toxicological applications.
Annette Zschiesche, Birgit Schneider, Ilona Nordhorn, Carsten Baessmann, Laura M. Huppertz, Jürgen Kempf   +5 more
wiley   +1 more source

Inhibition of hepatitis C virus by Avicennia marina (Forssk.) Vierh. leaves extract: Liquid chromatography-high-resolution mass spectrometry, network pharmacology, molecular simulation, and in vitro study [PDF]

Journal of HerbMed Pharmacology
Introduction: Avicennia marina (Forssk.) Vierh. is known for its antiviral property. However, therapeutic mechanisms of the plant against hepatitis C virus (HCV) are still unclear. Therefore, this study aimed to determine the potential of A.
Muhammad Arba, Sunandar Ihsan, Fathar Muhamad Irfansya Hatma, Jamili Jamili, Setyanto Tri Wahyudi, Tutik Sri Wahyuni   +5 more
doaj   +1 more source

Identification and Characterization of the Designer Opioid N‐Pyrrolidino Fluetonitazene in Nasal Spray

Drug Testing and Analysis, EarlyView.
N‐Pyrrolidino fluetonitazene, a synthetic opioid, was identified and characterized in a nasal spray using GC‐MS, LC‐QTOF‐MS, NMR and FT‐IR. ABSTRACT Detection of drugs in non‐biological samples serves as a fundamental basis for identifying emerging trends in the field of new psychoactive substances and provides valuable information for optimizing ...
Fabian Picht, Valentin Cepus, Rona Hohlfeld, Julian Klingbeil, Marco Weber   +4 more
wiley   +1 more source

First identification report for amino acid composition of red algae Gracilaria spp. obtained from Central Java, Indonesia

BioTechnologia
Gracilaria is a genus of red algae found mainly in Asia. Various species of Gracilaria are distributed throughout Indonesia’s marine waters, especially in coastal areas, and are cultivated for research and economic purposes.
Klara Kharisma Bunga Chandra, Tri Rini Nuringtyas, Tri Joko Raharjo   +2 more
doaj   +1 more source

Entwicklung von auf LC-HRMS basierenden Stabilisotopen-Markierungstechniken

, 2014
Ungerichtete Metabolomik-Ansätze haben das Ziel sämtliche niedermolekularen Stoffwechselprodukte eines biologischen Systems (Metabolom) ganzheitlich zu erfassen.
Kluger, Bernhard
core  

Detection of the GH Analogue Redalsomatropin Alfa in Sports Drug Testing: Immunological Approaches and LC‐HRMS/MS

Drug Testing and Analysis, EarlyView.
After evaluating the compatibility of the GH analogue redalsomatropin alfa with approved doping control immunoassays for rhGH, it was implemented into the existing detection method for somatrogon employing affinity purification with GHR‐Fc‐conjugated magnetic beads, tryptic digestion, and LC‐HRMS/MS to allow for a specific and sensitive detection ...
Katja Walpurgis, Andreas Thomas, Jasmin Thelen, Bettina Majer, Maneera Al‐Jaber, Wadha Abushareeda, Mario Thevis   +6 more
wiley   +1 more source

QuEChERS-Based LC-MS/MS and HRMS Methods for PFAS Determination in Food: A Systematic Review

Foods
Per- and polyfluoroalkyl substances (PFAS) are persistent contaminants that require very strict performance criteria from the methods that want to analyze them in food for research or regulatory purposes.
Francesco Giuseppe Galluzzo, Gaetano Cammilleri, Licia Pantano, Vittorio Calabrese, Maria Drussilla Buscemi, Elisa Maria Domenica Messina, Calogero Alfano, Dario Bonomo, Andrea Pulvirenti, Andrea Macaluso, Vincenzo Ferrantelli, Gianluigi Maria Lo Dico   +11 more
doaj   +1 more source

A Sensitive LC-MS/MS Method for Palytoxin Using Lithium Cationization

Toxins, 2018
Palytoxin (PlTX) and analogues are produced by certain dinoflagellates, sea anemones, corals and cyanobacteria. PlTX can accumulate in the food chain and when consumed it may cause intoxication with symptoms like myalgia, weakness, fever, nausea, and ...
Mirjam D. Klijnstra, Arjen Gerssen
doaj   +1 more source

Analysis and Characterization of Kisspeptin and Its Analogues in Serum and Urine Samples by Liquid Chromatography–High‐Resolution Mass Spectrometry for Doping Control Purposes

Drug Testing and Analysis, EarlyView.
Sensitive LC‐HRMS methods were established for the detection of kisspeptin and its analogues in serum and urine, alongside their analytical and metabolic characterization. Stability studies were conducted in serum, plasma, and urine, highlighting the importance of appropriate sample handling for reliable anti‐doping analysis.
Sophia Krombholz, Linus Korsmeier, Andreas Thomas, Mario Thevis   +3 more
wiley   +1 more source

Beyond degradation: LC-HRMS based tracking of transformation products and toxicity during photocatalytic removal of ceftazidime via advanced oxidation processes

Sustainable Chemistry for the Environment
High-resolution mass spectrometry combined with liquid chromatography (LC-HRMS) was employed to comprehensively investigate transformation pathways and transformation products (TPs) formation during the degradation of ceftazidime (CAZ).
Eleni Evgenidou, Panagiotis Pavlidis, Androniki Rapti, Lelouda-Athanasia Koronaiou, Vasileios Alampanos, Dimitra Lambropoulou   +5 more
doaj   +1 more source