Results 131 to 140 of about 330,504 (280)

A Selectfluor‐based Polonovski Rearrangement Leading to Novel Entities for Synthetic and Medicinal Applications

Chemistry – A European Journal, EarlyView.
Starting from carboxylic acids and Selectfluor‐derivatives, functionalized diazabicyclooctanes can be obtained via a novel Polonovski‐type rearrangement proceeding under mild reaction conditions. Besides their use in organic synthesis the unique structure and reactivity of the rearrangement products enables applications in medicinal chemistry ...
Jakob Kuhn, Susanne Gradl, Vanessa Osterloh, Peter Gmeiner, Harald Hübner, Markus R. Heinrich   +5 more
wiley   +1 more source

LC-HRMS ANALYSIS AND ISOLATION OF BIOACTIVE COMPOUNDS FROM SONGGA WOOD (Strychnos ligustrina) USING RADIAL CHROMATOGRAPHY

Songga Wood (Strychnos ligustrina) is a traditional medicinal plant that has been used to treat malaria, rheumatism, and wounds. The therapeutic potential of this species is primarily attributed to its secondary metabolites, particularly alkaloids, which
Fery Indradewi Armadany, Novita Sari Syukur, Nasrudin, Irnawati, Fadhliyah Malik, Asriullah Jabbar, Sahidin, Muhammad Ilyas Y, Abd. Arif Rachmat Halim   +8 more
core   +1 more source

Decoding Heptazine Architectures: From Molecular Association to Structural Insight

Chemistry – A European Journal, EarlyView.
A comprehensive study (NMR and theoretical) of three novel heptazine derivatives that self‐assemble into dimers has been conducted, highlighting their versatility as a platform for multifunctional supramolecular and optoelectronic materials. ABSTRACT Heptazine (Hpz) derivatives display remarkable supramolecular organization governed by noncovalent ...
Silvia del Moral, Daniel Barrena‐Espés, Julen Munarriz, Matthias Lehmann, Pilar Romero, José Luis Serrano   +5 more
wiley   +1 more source

Control of Gemcitabine Activity With Blue and Red Light

Chemistry – A European Journal, EarlyView.
Treating cancer with chemotherapy is generally associated with many side effects, which can be addressed by selectively releasing the desired drugs with visible light. Sixteen new blue light‐activatable cytostatics were introduced, with the gemcitabine derivative exhibiting ideal properties.
Nils F. Kersten, Konstantin L. Stock, Marius Hyprath, Hannah Weisser, Timo Weinrich, Dieter Steinhilber, Alexander Heckel   +6 more
wiley   +1 more source

Characterizing the nasal metabolome and exposome by LC-HRMS: Opportunities and challenges

Microchemical Journal
The nasal cavity represents a host-microbial interface critical to respiratory defense against viral infections, including those caused by influenza virus, respiratory syncytial virus, rhinovirus or SARS-CoV-2. Although the nasal microbiome itself has been well characterized, the nasal metabolome remains comparatively unexplored.
Berger, Sabrina, Peach, Jesse T., Martens, Anke, Zuccoli, Sonia, Wisgrill, Lukas, Warth, Benedikt   +5 more
openaire   +2 more sources

Multimodal Fluorescent MOF@BODIPY Platform: Bridging Sensing and Mechanistic Insight

Chemistry – A European Journal, EarlyView.
ABSTRACT Hybrid metal–organic frameworks (MOFs) that integrate organic chromophores constitute powerful platforms for optical sensing by combining structural order with tunable photophysics. Incorporating photoresponsive chromophores into MOFs enables sensitive probing of guest–framework interactions through well‐defined luminescent signatures. Herein,
Alejandro Cortés‐Villena, Paula Rodrigo‐Martínez, José A. Sáez, Pablo Gaviña, Emilio Pardo, Raquel E. Galian, Sergio Armenta, Héctor Martínez‐Pérez‐Cejuela, José Manuel Herrero‐Martínez   +8 more
wiley   +1 more source

Rhodium‐Catalyzed Synthesis of Enantioenriched α‐Substituted Primary Amines Through Asymmetric Transfer Hydrogenation

Chemistry – A European Journal, EarlyView.
Enantioenriched α‐substituted primary amines are efficiently prepared by rhodium‐catalyzed asymmetric transfer hydrogenation of ortho‐hydroxyaryl N─H imines under mild conditions using a low catalyst loading and ammonium formate as the hydrogen source in high yields (up to 99%) and enantioselectivities (up to 99% ee).
Chonghuo Liu, Guillaume Lefèvre, Qin Yin, Phannarath Phansavath, Virginie Ratovelomanana‐Vidal   +4 more
wiley   +1 more source

Increasing the Separation Capacity of Intact Histone Proteoforms Chromatography Coupling Online Weak Cation Exchange-HILIC to Reversed Phase LC UVPD-HRMS

, 2018
Top-down proteomics is an emerging analytical strategy to characterize combinatorial protein post-translational modifications (PTMs). However, sample complexity and small mass differences between chemically closely related proteoforms often limit the ...
Gargano, Andrea F.G., Zhou, Mowei, Shaw, J.B., Fillmore, Thomas L., Christopher S. Wilkins (4175983), Christopher S. Wilkins, Paša-Tolić, L., Govert W. Somsen (1990435), Mowei Zhou, Thomas L. Fillmore, Zhou, M., Paša-Tolić, Ljiljana, Gargano, Andrea F.G.; id_orcid, Moore, Ronald J., Shaw, Jared B., Ljiljana Paša-Tolić (1491175), Andrea F. G. Gargano, Wilkins, C.S., Gargano, A.F.G., Andrea F. G. Gargano (1407400), Somsen, Govert W., Ljiljana Paša-Tolić, Thomas L. Fillmore (1324890), Wilkins, Christopher S., Govert W. Somsen, Fillmore, T.L., Moore, R.J., Ronald J. Moore (176001), Jared B. Shaw (1308051), Ronald J. Moore, Mowei Zhou (1473115), Jared B. Shaw, Somsen, G.W.   +32 more
core   +1 more source

Non‐Invasive Estimation of Systemic Drug Exposure Using Exhaled Breath Metabolomics in Humans: A Translational Proof‐of‐Concept Study

Clinical Pharmacology &Therapeutics, EarlyView.
Accurate assessment of systemic drug exposure in humans remains challenging, as conventional approaches rely on intermittent blood sampling and laboratory‐based assays that are invasive and provide limited temporal resolution. Exhaled breath contains volatile and semi‐volatile compounds arising from drug metabolism and downstream biological processes ...
Kai Fricke, Diego M. Baur, Kapil Dev Singh, Felix Schmidt, Kathrin Müsch, Noriane A. Sievi, Marco Di Donato, Anton Schmick, Jonas Herth, Silvia Ulrich, Pablo Sinues, Marian Galovic, Malcolm Kohler   +12 more
wiley   +1 more source

Analysis of In Vitro Mirtazapine Metabolites in Human Liver Microsomes by LC-HRMS.

Fa yi xue za zhi
To establish and optimize an in vitro incubation system with human liver microsomes and investigate the in vitro metabolites and possible metabolic pathways of mirtazapine.Three major metabolites of mirtazapine were selected to optimize the incubation conditions of liver microsomes.
ZHANG Ying, ZHANG Wen-fang, XU Duo-qi, QIN Shi-yang, YANG Shi-yun, QIAO Jing   +5 more
openaire   +2 more sources