Results 101 to 110 of about 255,317 (292)

Versatile Palladium‐Catalyzed C‐H Arylation of Fluoroarenes with 2‐Chloropyridine Derivatives

Chemistry – A European Journal, EarlyView.
Direct C─H arylation of fluoroarenes with 2‐chloropyridines is enabled by a simple Pd/SPhos system in isopropyl acetate. The method uses inexpensive reactants and shows broad scope and high yields. DFT computations explain reactivity and selectivity.
Federico Belnome, Péter P. Fehér, András Stirling, Csongor G. Németh, Tamás Hergert, György M. Keserű, Péter Ábrányi‐Balogh   +6 more
wiley   +1 more source

LC–HRMS Identification of Saponins and Correlation with Antimicrobial and Anticoccidial Properties

Natural Product Communications
Objectives This study investigated the relationship between the chemical composition of Yucca schidigera saponins and their antimicrobial and anticoccidial activities against Clostridium perfringens and Eimeria tenella . Methods Extracts of Y. schidigera
Maria Federica Marchesi, Martina Felici, Jaewoo Choi, Teresa Gazzotti, Roberta Majer, Benedetta Tugnoli, Ester Grilli, Jan F. Stevens   +7 more
doaj   +1 more source

Highly Potent Fluorogenic Ligands for Triplex DNA: 5‐Substituted 2‐(Naphthalen‐2‐yl)‐4H‐Chromen‐4‐Ones

Chemistry – A European Journal, EarlyView.
5‐Substituted 2‐(naphthalen‐2‐yl)‐4H‐chromen‐4‐ones are reported as a novel class of highly potent and selective triplex DNA ligands. These ligands induce triplex formation at submicromolar concentrations and inhibit enzymatic activity via ligand‐mediated triplex formation.
Nghia Tran, Landy Gu, Krege M. Christison, Kalee Thao, Liang Xue   +4 more
wiley   +1 more source

Increasing the Separation Capacity of Intact Histone Proteoforms Chromatography Coupling Online Weak Cation Exchange-HILIC to Reversed Phase LC UVPD-HRMS

, 2018
Top-down proteomics is an emerging analytical strategy to characterize combinatorial protein post-translational modifications (PTMs). However, sample complexity and small mass differences between chemically closely related proteoforms often limit the ...
Gargano, Andrea F.G., Zhou, Mowei, Shaw, J.B., Fillmore, Thomas L., Christopher S. Wilkins (4175983), Christopher S. Wilkins, Paša-Tolić, L., Govert W. Somsen (1990435), Mowei Zhou, Thomas L. Fillmore, Zhou, M., Paša-Tolić, Ljiljana, Gargano, Andrea F.G.; id_orcid, Moore, Ronald J., Shaw, Jared B., Ljiljana Paša-Tolić (1491175), Andrea F. G. Gargano, Wilkins, C.S., Gargano, A.F.G., Andrea F. G. Gargano (1407400), Somsen, Govert W., Ljiljana Paša-Tolić, Thomas L. Fillmore (1324890), Wilkins, Christopher S., Govert W. Somsen, Fillmore, T.L., Moore, R.J., Ronald J. Moore (176001), Jared B. Shaw (1308051), Ronald J. Moore, Mowei Zhou (1473115), Jared B. Shaw, Somsen, G.W.   +32 more
core   +1 more source

Bioresponsive pseudoGlucosinolates (psGSLs) Release Isothiocyanates (ITCs) in the Presence of Nitroreductases

Chemistry – A European Journal, EarlyView.
This work introduces the concept of pseudoglucosinolates (psGSLs) and reports the synthesis and evaluation of nitroreductase‐responsive psGSLs. These compounds represent a complementary prodrug strategy to natural glucosinolates (GSLs) for the controlled release of isothiocyanates (ITCs), enabling bio‐responsive protein labeling, as demonstrated in ...
Claire C. Jimidar, Charity S. G. Ganskow, Mervic D. Kagho, Aishi Chakrabarti, Lorenz Wiese, Michael Zollo, Ulrike Beutling, Leona C. Cesar, Julia Morud, Kamila Bugaj, Mark Brönstrup, Stephan A. Sieber, Stephan M. Hacker, Philipp Klahn   +13 more
wiley   +1 more source

Targeted Isolation of Prenylated Flavonoids from Paulownia tomentosa Fruit Extracts via AI-Guided Workflow Integrating LC-UV-HRMS/MS

Metabolites
Objectives: This study presents a versatile, AI-guided workflow for the targeted isolation and characterization of prenylated flavonoids from Paulownia tomentosa (Thunb.) Steud. (Paulowniaceae). Methods: The approach integrates established extraction and
Tomas Rypar, Lenka Molcanova, Barbora Valkova, Ema Hromadkova, Christoph Bueschl, Bernhard Seidl, Karel Smejkal, Rainer Schuhmacher   +7 more
doaj   +1 more source

Glutathione-Conjugates of Deoxynivalenol in Naturally Contaminated Grain Are Primarily Linked via the Epoxide Group

Toxins, 2016
A glutathione (GSH) adduct of the mycotoxin 4-deoxynivalenol (DON), together with a range of related conjugates, has recently been tentatively identified by LC-MS of DON-treated wheat spikelets. In this study, we prepared samples of DON conjugated at the
Silvio Uhlig, Ana Stanic, Ingerd S. Hofgaard, Bernhard Kluger, Rainer Schuhmacher, Christopher O. Miles   +5 more
doaj   +1 more source

Homo‐/Heterodimeric Substrates Bias the Type and Multiplicity of Hydroxamic Acid Chelators Assembled by a NIS Synthetase DesD

Chemistry – A European Journal, EarlyView.
Chemoenzymatic reactions using the siderophore synthetase DesD from Salinispora tropica and hydroxamic acid substrates (native, non‐native) with different multiplicities (monomer, dimer) and components (homo‐/heterodimer) followed different reaction trajectories, which biased the architectures of the chelator major products and indicated DesD contains ...
Callum A. Rosser, Todd E. Markham, Rachel Codd   +2 more
wiley   +1 more source

Determination of adulteration in hair serums by LC-HRMS §

Journal of Chemical Metrology, 2023
Ahmet C. Gören, T. Cagdas Akalın, Şule Yalçın, Ayşenur Gunaydin Akyildiz   +3 more
openaire   +1 more source

LC-HRMS Biomarker Suspect Screening in Low Dose Studies

ISEE Conference Abstracts, 2018
Exposure biomarker development is a time consuming procedure, starting with identification of presumably appropriate metabolites of the xenobiotic in question.
Daniel Bury, Frederik Lessmann, Kathrin Papadopoulos, Alexandra Nehring, Tobias Weiss, Heiko Hayen, Thomas Brüning, Holger Martin Koch   +7 more
openaire   +1 more source