Results 161 to 170 of about 21,610 (241)

LC-HRMS Coupling to Feature-Based Molecular Networking to Efficiently Annotate Monoterpene Indole Alkaloids of <i>Alstonia scholaris</i>. [PDF]

Plants (Basel)
He YJ, Qin Y, Luo XD.
europepmc   +1 more source

Multiple Heart‐Cut Ion‐Exchange Chromatography‐Reversed‐Phase Liquid Chromatography Platform for Online Desalting and Fractionation of Monoclonal Antibody Charge Variants

Journal of Separation Science, Volume 49, Issue 3, March 2026.
Representation of the IMPROBE platform for profiling monoclonal antibody charge variants with online desalting, fractionation, and identification. ABSTRACT Minor deviations in biopharmaceutical manufacturing processes, such as those used for monoclonal antibodies (mAbs), can introduce structural modifications that alter protein efficacy and safety ...
Annika A. M. van der Zon, Chuck van der Veen, Mandon Cheung, Melissa Baerenfaenger, Govert W. Somsen, Andrea F. G. Gargano   +5 more
wiley   +1 more source

The first report from Ankara on the presence of xylazine abuse in blood and urine samples using a validated LC-HRMS method. [PDF]

Int J Legal Med
Erol Öztürk Y, Yeter O, Aslıyüksek H, Oztuna A, Sezigen S, Demirel G.   +5 more
europepmc   +1 more source

Ion Chemistry in Dielectric Barrier Discharge Ionization: Recent Advances in Direct Gas Phase Analyses

Mass Spectrometry Reviews, Volume 45, Issue 2, Page 193-217, March/April 2026.
ABSTRACT Dielectric barrier discharge ionization (DBDI) sources, employing low‐temperature plasma, have emerged as sensitive and efficient ionization tools with various atmospheric pressure ionization processes. In this review, we summarize a historical overview of the development of DBDI, highlighting key principles of gas‐phase ion chemistry and the ...
Kseniya Dryahina, Miroslav Polášek, Juraj Jašík, Kristýna Sovová, Patrik Španěl   +4 more
wiley   +1 more source

Untargeted LC-HRMS Metabolomics and Chemometrics of <i>Aloe vera</i> Across Diverse Geographical Origins and Cultivation Practices. [PDF]

Plants (Basel)
Anzano A, Grauso L, de Falco B, Lanzotti V.   +3 more
europepmc   +1 more source

Practical Applications of Secondary/Extractive Electrospray Ionization (SESI): A Versatile Tool for Real‐Time Chemical Analysis

Mass Spectrometry Reviews, Volume 45, Issue 2, Page 392-428, March/April 2026.
ABSTRACT In the 1980s, researchers discovered the remarkable ability of electrospray plumes to effectively ionize gas‐phase molecules via secondary ionization. Around 20 years later—coinciding with the ambient mass spectrometry revolution—secondary electrospray ionization (SESI) and extractive electrospray ionization (EESI) coupled to mass spectrometry
Xin Luo, Huiling Wang, Xiaolan Hu, Sasho Gligorovski, Xue Li, Pablo Sinues   +5 more
wiley   +1 more source

Turn‐Induction in Peptides Incorporating Novel Cyrene‐Derived α,α‐Disubstituted Amino Acid

Journal of Peptide Science, Volume 32, Issue 3, March 2026.
Novel chiral cyrene‐derived Cyr residues were incorporated into peptides. The α,α‐disubstituted amino acid residue was introduced using the Ugi reaction. X‐ray crystallographic analysis of R‐ and S‐Cyr residues indicated preference to adopt left‐ and right‐handed α‐helical conformations, respectively.
Kajumee Bora Bhowal, Raphael Hitti, William D. Lubell   +2 more
wiley   +1 more source

Combined detection of inhibitors of the activin receptor signaling pathways (IASPs) by means of LC-HRMS/MS for human doping control. [PDF]

Sci Rep
Sakellariou P, Walpurgis K, Thomas A, Marchand A, Miller G, Dellanna F, Thevis M.   +6 more
europepmc   +1 more source

Covalent Peptide‐Based N‐Myc/Aurora‐A Inhibitors Bearing Sulfonyl Fluoride Warheads

Journal of Peptide Science, Volume 32, Issue 3, March 2026.
N‐Myc‐derived peptidomimetics bearing aryl sulfonyl fluoride warheads were shown to act as effective N‐Myc/Aurora‐A PPI inhibitors, selectively labelling Aurora‐A in a recognition‐directed manner. ABSTRACT Orthosteric inhibition of the N‐Myc/Aurora‐A protein–protein interaction (PPI) represents a potential mechanism by which degradation of N‐Myc can be
Robert S. Dawber, Diana Gimenez, George W. Preston, Megan H. Wright, Richard Bayliss, Stuart L. Warriner, Andrew J. Wilson   +6 more
wiley   +1 more source