Results 71 to 80 of about 23,319 (231)

Immediate diagnosis of cutaneous metastases with optical coherence tomography, line‐field confocal optical coherence tomography and dermoscopy: A case series

JEADV Clinical Practice
Background Cutaneous metastases (CM) are a frequent finding in the follow‐up of malignant tumours. Objectives CM were examined with dermoscopy, optical coherence tomography (OCT), dynamic OCT and line‐field confocal OCT (LC‐OCT) to describe common ...
Sarah Hobelsberger, Frank Friedrich Gellrich, Jörg Laske, Friedegund Meier, Stefan Beissert, Julian Steininger   +5 more
doaj   +1 more source

Atrophic Skeletal Muscle‐Derived Extracellular Vesicles Transfer miR‐125a‐5p to Inhibit Bone Formation in Osteoporosis during Aging

Advanced Science, EarlyView.
A muscle‐bone endocrine pathway in aging is revealed in which extracellular vesicles released from atrophic skeletal muscle (Aged‐SKM‐EVs) inhibit bone formation. These EVs deliver miR‐125a‐5p to osteoblasts, thereby suppressing the SIRT7‐Sp7 signaling axis and osteogenic differentiation.
Xiaoyan Shao, Pan Zhang, Zhidan Fan, Jiaquan Lin, Xiang Chen, Na Liu, Wang Gong, Yi He, Yining Zhou, Tianshu Shi, Yong Shi, Yuze Ma, Wentian Gao, Haosheng Wang, Depeng Fang, Chengzhi Wang, Wenshu Wu, Wenjin Yan, Jianghui Qin, Dongyang Chen, Haiguo Yu, Qing Jiang, Baosheng Guo   +22 more
wiley   +1 more source

Line-Field Confocal Optical Coherence Tomography for the Diagnosis of Skin Tumors: A Systematic Review and Meta-Analysis

Diagnostics
A line-field confocal optical coherence tomography (LC-OCT) combines confocal microscopy and optical coherence tomography into a single, rapid, easy-to-use device.
Shazli Razi, Yen-Hong Kuo, Gaurav Pathak, Priya Agarwal, Arianna Horgan, Prachi Parikh, Farah Deshmukh, Babar K. Rao   +7 more
doaj   +1 more source

IL‐4/STAT6‐signaling Influences Local Inflammation and Regeneration Processes During Acute Pancreatitis and Promotes Fibrosis by a Direct Activation of Pancreatic Fibroblasts During Chronic Pancreatitis

Advanced Science, EarlyView.
IL‐4/IL‐13/STAT6 signaling plays a crucial for the suppression of pro‐inflammation during acute pancreatitis and supports acinar cell regeneration but has only minor impact on fibrogenesis during chronic form of the disease. IL‐4/IL‐13 induce the expression of certain collagens directly in pancreatic fibroblasts via STAT6 activation, whereas ...
ElSheikh H, Salvers A, Piesker J, Buchholz S, Lange R, Ameling S, Steil L, Hammer E, Homuth G, Völker U, Bröker BM, Weiss FU, Sendler M, Glaubitz J   +13 more
wiley   +1 more source

Line‐field confocal optical coherence tomography and optical coherence tomography for distinguishing basal cell carcinoma from dermal nevus: A case report

JEADV Clinical Practice
Basal cell carcinoma (BCC) is the most frequent skin cancer with a rising incidence. It can imitate benign lesions for example, dermal nevus clinically and dermoscopically.
Deborah Winkler, Anna Desch, Martha Paola Mireles, Julia Welzel, Sandra Schuh   +4 more
doaj   +1 more source

Impact of Elevated Intraocular Pressure on Lamina Cribrosa Oxygenation: A Combined Experimental–Computational Study on Monkeys

Ophthalmology Science
Purpose: To evaluate how lamina cribrosa (LC) oxygenation is affected by tissue distortions resulting from elevated intraocular pressure (IOP). Design: Experimental study on 4 monkeys, histology, and computational analysis.
Yuankai Lu, PhD, Yi Hua, PhD, Bingrui Wang, PhD, Qi Tian, Fuqiang Zhong, PhD, Andrew Theophanous, Shaharoz Tahir, Po-Yi Lee, PhD, Ian A. Sigal, PhD   +8 more
doaj   +1 more source

TOGR3, a Proteasome β4 Subunit, Orchestrates Sugar Homeostasis to Trade Off Growth and Thermotolerance in Rice

Advanced Science, EarlyView.
This study identifies a novel thermoregulatory mechanism in rice: TOGR3 partners with 26S proteasome subunits, including TT1, to drive thermoresponsive ubiquitin–proteasome activity, maintaining sugar homeostasis in stomatal regulation to balance growth and stress resistance.
Biyao Zhang, Xiaoyan Wu, Ting Xu, Feifei Guo, Xiaolu Shen, Cuiping Meng, Yanan Wang, Xue Han, Hong Zhao, Yongbiao Xue   +9 more
wiley   +1 more source

Targeting the GPX4–FUNDC1 Interaction with Magnesium Lithospermate B Attenuates Sepsis‐Associated Lung Injury

Advanced Science, EarlyView.
The diagram depicts the endothelial‐protective mechanism of magnesium lithospermate B (MLB) in sepsis‐associated lung injury. MLB binds GPX4 at Gly79, disrupts its interaction with FUNDC1, prevents mitophagy‐mediated GPX4 degradation, restores mitophagic flux, reduces ROS, and limits ferroptosis.
Zhixi Li, Chang Liu, Zhaoxue Ma, Dongyou Zheng, Renkai Wang, Yongjing Yu, Guangmin Chen, Chenglong Li, Yue Bu, Hang Cao, Bing Zhang   +10 more
wiley   +1 more source

Non-invasive imaging for monitoring nodular inflammatory lesions in hidradenitis suppurativa

Dermatology Reports
Dear Editor, Noninvasive skin diagnostic techniques are widely used in dermatology, and their role in the diagnosis and monitoring of inflammatory skin diseases is still being explored.
Giuseppe Rizzuto, Federica Rega, Nevena Skroza, Concetta Potenza, Steven Paul Nisticò, Giovanni Pellacani, Nicoletta Bernardini, Annunziata Dattola   +7 more
doaj   +1 more source

Neuroprotective Effects of Time‐Restricted Feeding Combined With Different Protein Sources in MPTP‐Induced Parkinson's Disease Mice Model and Its Modulatory Impact on Gut Microbiota Metabolism

Advanced Science, EarlyView.
Time‐restricted feeding (TRF) exerts protein‐dependent neuroprotective effects in an MPTP‐induced Parkinson's disease model. In casein‐fed mice, TRF improves gut barrier integrity and reduces neuroinflammation, possibly via modulation of Allobaculum and BCAAs.
Ting Li, Jian Wu, Sheng‐Yang Zhou, Ming‐An Li, Li‐Ping Zhao, Ao Wang, Yi‐Zhi Song, Wen‐Yan Huang, Lu‐Lu Tan, Chen‐Meng Qiao, Wei‐Jiang Zhao, Chun Cui, Yan‐Qin Shen   +12 more
wiley   +1 more source