Results 71 to 80 of about 24,164 (284)

Line‐field confocal optical coherence tomography in lichen planopilaris and frontal fibrosing alopecia: a pilot study [PDF]

Background and Objectives Lichen planopilaris (LPP) and frontal fibrosing alopecia (FFA) are common causes of cicatricial alopecia. While several studies have demonstrated the usefulness of non-invasive imaging methods such as reflectance confocal ...
Deußing, Maximilian, Eyssele, Tamara, French, Lars E., Hartmann, Daniela, Lange, Silvan, Nutz, Marie‐Christine, Sattler, Elke C., Schuh, Sandra, Senner, Sonja, Welzel, Julia   +9 more
core   +2 more sources

Atrophic Skeletal Muscle‐Derived Extracellular Vesicles Transfer miR‐125a‐5p to Inhibit Bone Formation in Osteoporosis during Aging

Advanced Science, EarlyView.
A muscle‐bone endocrine pathway in aging is revealed in which extracellular vesicles released from atrophic skeletal muscle (Aged‐SKM‐EVs) inhibit bone formation. These EVs deliver miR‐125a‐5p to osteoblasts, thereby suppressing the SIRT7‐Sp7 signaling axis and osteogenic differentiation.
Xiaoyan Shao, Pan Zhang, Zhidan Fan, Jiaquan Lin, Xiang Chen, Na Liu, Wang Gong, Yi He, Yining Zhou, Tianshu Shi, Yong Shi, Yuze Ma, Wentian Gao, Haosheng Wang, Depeng Fang, Chengzhi Wang, Wenshu Wu, Wenjin Yan, Jianghui Qin, Dongyang Chen, Haiguo Yu, Qing Jiang, Baosheng Guo   +22 more
wiley   +1 more source

Unusual site presentation of dermatitis herpetiformis: line-field confocal optical coherence tomography for effective management

Dermatology Reports
Dermatitis herpetiformis (DH) is an uncommon autoimmune blistering skin disorder linked to gluten sensitivity. This report describes the line-field confocal optical coherence tomography (LC-OCT) features in a DH case, correlating with histopathological ...
Luca Bettolini, Stefano Bighetti, Sara Rovaris, Iacopo Ghini, Vincenzo Maione   +4 more
doaj   +1 more source

A Nanoparticle‐Integrated Complete Manufacturing Pipeline of Chemically Engineered Exosomes

Advanced Science, EarlyView.
We report a novel manufacture technology of chemically engineered exosomes. The four steps of manufacturing, i.e., biogenesis, loading, isolation, and storage, are integrated by the use of a nanoparticle. The manufacture technology incorporates three innovative components, i.e., a new nano‐bio effect, a new composite nanoparticle, and a new isolation ...
Xiaowei Wen, Zixing Xu, Zerun Hao, Yanming Chen, Kai Xie, Haofan Yin, Xueying Wang, Jie Min, Sihan Sun, Baiding Chen, Chengxiu Ling, Mingming Xu, Yizhao Chen, Gang Ruan   +13 more
wiley   +1 more source

Structure-function relationships in glaucoma using enhanced depth imaging optical coherence tomography-derived parameters: a cross-sectional observational study

BMC Ophthalmology, 2019
Background To investigate structural and functional correlations in glaucoma patients using enhanced depth imaging spectral-domain optical coherence tomography (EDI OCT)-derived parameters.
Flavio S. Lopes, Igor Matsubara, Izabela Almeida, Syril K. Dorairaj, Roberto M. Vessani, Augusto Paranhos Jr, Tiago S. Prata   +6 more
doaj   +1 more source

A simple method for sphingolipid analysis of tissues embedded in optimal cutting temperature compound[S]

Journal of Lipid Research, 2020
MS-assisted lipidomic tissue analysis is a valuable tool to assess sphingolipid metabolism dysfunction in disease. These analyses can reveal potential pharmacological targets or direct mechanistic studies to better understand the molecular underpinnings ...
Timothy D. Rohrbach, April E. Boyd, Pamela J. Grizzard, Sarah Spiegel, Jeremy Allegood, Santiago Lima   +5 more
doaj   +1 more source

A Tac1‐Expressing Brainstem Pathway Underlies the Pathogenesis of Trigeminal Neuralgia

Advanced Science, EarlyView.
A critical TG‐Sp5CTac1‐PBNTac1 pathway drives trigeminal neuropathic pain (TNP). Tac1‐expressing parabrachial nucleus (PBNTac1) neurons exhibit heightened responses to innocuous stimuli in TNP, and chemogenetic inhibition of these neurons effectively prevents TNP development.
Liting Sun, Jia‐Jia Wang, Xiang‐Yu Li, Xin‐Yi Lin, Juan Li, Qiu‐Tong Yu, Zi‐Han Wang, Xue‐Ping Gao, Lei Jin, Wei‐Ke Li, Tian‐Lin Cheng, Juan Deng   +11 more
wiley   +1 more source

Oral Streptococcus salivarius Couples Neutrophil IRGM1 Signaling to NET Formation and Colorectal Cancer Metastasis

Advanced Science, EarlyView.
The oral bacterium Streptococcus salivarius promotes colorectal cancer metastasis by inducing neutrophil extracellular trap (NET) formation. Mechanistically, IRGM1–IQGAP1 interaction activates Wnt5a–PI3K/AKT signaling in neutrophils, driving NET‐mediated tumor progression.
Fengyi Liu, Yuan Wang, Hengxuan Cai, Qianwen Yue, Xueli Liu, Xuanwen Bao, Zeng Wang, Xuehan Li, Lai Wei, Zhihua Zhang, Fan Xing, Yi Xu, Xianjun Li, Wei Xu   +13 more
wiley   +1 more source

Bifidobacterium Pseudolongum‐Derived Acetate Attenuates Acute Pancreatitis Through GPR43‐Mediated Suppression of M1 Macrophage Polarization

Advanced Science, EarlyView.
The severity of acute pancreatitis (AP) is linked to reduced abundance of Bifidobacterium pseudolongum (B. pseudolongum). Administration of B. pseudolongum or its key metabolite acetate alleviates pancreatic and systemic inflammation by suppressing M1 macrophage polarization.
Langyi Guan, Xueyang Li, Cong He, Pan Zheng, Yaoyu Zou, Qi Zhu, Xin Li, Jie Liang, Junmin Yang, Li Zhang, Yuman Ye, Jianhua Wan, Huajing Ke, Jianping Liu, Nonghua Lu, Nianshuang Li, Yin Zhu   +16 more
wiley   +1 more source

Morphological Evaluation of Facial Pigmented Lesions With Line-Field Confocal Optical Coherence Tomography: Correlation With Reflectance Confocal Microscopy. A Pilot Study

Dermatology Practical & Conceptual
Introduction: Facial pigmented lesions pose significant challenges for diagnosis and treatment planning due to their anatomical topography and complexity.
Clément Lenoir, Mariano Suppa, Simone Soglia, Susana Puig, Linda Tognetti, Elisa Cinotti, Carmen Orte Cano, Gwendoline Diet, Pietro Rubegni, Jean-Luc Perrot, Veronique del Marmol, Josep Malvehy, Javiera Pérez-Anker   +12 more
doaj   +1 more source