Results 221 to 230 of about 60,310 (255)

[Study on proteins in Guangdilong by nano LC/orbitrap fusion lumos HR-MS].

Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 2019
In the present study,fresh Guangdilong( GD),originating from Pheretima aspergillum,was taken as the object. The total proteins from GD were firstly separated by SDS-PAGE according to their molecular weights and in-gel digestion was then performed.After that,the peptides were analyzed by nano LC/orbitrap fusion lumos high resolution mass spectrometry ...
Hong-Shuang, Dong, Jing-Xian, Zhang, Qing, Hu, Yan-Chun, Wang, Jian, Sun, Su, Zhang, Hong, Yu, Rui, Feng, Xiu-Hong, Mao, Shen, Ji   +9 more
openaire   +1 more source

In vitro and in vivo human metabolism of a synthetic cannabinoid EAM-2201 detected by LC–quadrupole-ion trap-MS/MS and high-resolution LC–Orbitrap-MS/MS

Forensic Toxicology, 2019
The aim of this study is to characterize the metabolites of EAM-2201 in human hepatocytes obtained in vitro and those in liver and urine specimens obtained in vivo from the autopsy of an EAM-2201 abuser. EAM-2201 was incubated with human hepatocytes for 3 h in a CO2 incubator and the metabolites of EAM-2201 were produced.
Kayoko Minakata, Itaru Yamagishi, Koutaro Hasegawa, Hideki Nozawa, Masako Suzuki, Takuya Kitamoto, Osamu Suzuki, Kanako Watanabe   +7 more
openaire   +1 more source

Metabolic Profiling of Canertinib: A Comprehensive Cross‐Species Investigation Using Advanced UPLC‐MS/MS and LC‐Orbitrap‐HRMS Techniques

Biomedical Chromatography
ABSTRACTCanertinib is an EGFR tyrosine kinase inhibitor intended for the treatment of leukemia and non–small cell lung cancer. This study described a UPLC‐MS/MS method for quantitatively assessing the metabolic stability of canertinib in liver microsomes.
Weiqi Yuan, Gang Shi, Lantu Gou, Jinliang Yang   +3 more
openaire   +1 more source

The use of LC-Orbitrap MS for the detection of Fusarium masked mycotoxins: the case of type A trichothecenes

World Mycotoxin Journal, 2012
‘Masked mycotoxins’ (mycotoxin glucosides) derived from type A trichothecenes (T-2 toxin and HT-2 toxin) were detected in commercially available maize powder reference material. These novel glucosides were identified as T-2 toxin-glucoside (T2-Glc) and HT-2 toxin-glucoside (HT2-Glc) on the basis of accurate mass measurements of characteristic ions and ...
H. Nakagawa, S. Sakamoto, Y. Sago, M. Kushiro, H. Nagashima   +4 more
openaire   +1 more source

Metabolic profiling of 5- Methoxy-N,N-diallyltryptamine in human liver microsomes and zebrafish using LC-Orbitrap MS

Journal of Chromatography B
The metabolic profiles of tryptamine-derived new psychoactive substance 5-Methoxy-N, N-diallyltryptamine (5-MeO-DALT) were investigated using both zebrafish and human liver microsome models. The ultra-high performance liquid chromatography Q Exactive Quadrupole-Orbitrap high resolution mass spectrometer (UPLC-Q-Orbitrap-HRMS) was employed to analyze ...
Liang, Meng, Yanjiao, Wang, Chenhao, Zhong, Sen, Zhao   +3 more
openaire   +2 more sources

Detection of N-(1-deoxy-D-fructos-1-yl) Fumonisin C1, C2 and C3 in Corn Powder by LC - Orbitrap MS

Journal of Environmental & Analytical Toxicology, 2018
Detection of N-(1-deoxy-D-fructos-1-yl) fumonisin C1, C2 and C3 (NDfrc-FCs) in a reference material of corn powder were performed with LC-Orbitrap MS. The peaks of NDfrc-FCs were eluted 0.1 ~ 0.3 min earlier than those of fumonisin C1, C2 and C3 (FCs), from the C18 column, probably due to their hydrophilic structures having the carbohydrate residues ...
Yosuke Matsuo, Kentaro Takahara, Hidemi Hatabayashi, Hiroyuki Nakagawa   +3 more
openaire   +1 more source

Front Cover: Separation and quantification of imidazoles in atmospheric particles using LC–Orbitrap‐MS

Journal of Separation Science, 2020
Monique Teich, Mechthild Schmidtpott, Dominik van Pinxteren, Jianmin Chen, Hartmut Herrmann   +4 more
openaire   +1 more source

Integrative oncology: Addressing the global challenges of cancer prevention and treatment

Ca-A Cancer Journal for Clinicians, 2022
Jun J Mao,, Msce, Lorenzo Cohen, Karen M Mustian   +2 more
exaly  

Obesity and adverse breast cancer risk and outcome: Mechanistic insights and strategies for intervention

Ca-A Cancer Journal for Clinicians, 2017
Cynthia Morata-Tarifa, Joyce M Slingerland   +1 more
exaly  

Multidisciplinary standards of care and recent progress in pancreatic ductal adenocarcinoma

Ca-A Cancer Journal for Clinicians, 2020
Aaron J Grossberg, William L Hwang, Anirban Maitra   +2 more
exaly