Results 211 to 220 of about 95,173 (266)

Determination of Concentration-Time-Mortality Relationships to Replace LC50 Values

Inhalation Toxicology, 1990
AbstractTo determine concentration-time-mortality relationships of ammonia (NH3), chlorine (Cl2), hydrogen sulfide (H2S), and phosgene (COCl2) in acute inhalation toxicity studies with rats and mice, groups of five males and five females each were exposed for different periods of time to different concentrations of the respective test atmospheres.
A. Zwart, J. H. E. Arts, J. M. Klokman-houweling, E. D. Schoen   +3 more
openaire   +2 more sources

Determination of lethal concentration (LC50) values

2013
Kuçukgul Gulec, A., Altinterim, B., Aksu, O.   +2 more
openaire   +2 more sources

Estimating Short-Term LC50 Values

Fire Technology, 1976
The authors discuss correlations of LC50 data and suggest that one possible use of them may be in the design of toxicity test procedures.
Carlos J. Hilado, Arthur Furst
openaire   +1 more source

Correlation between LC50 for Adult Fish and Fish Embryos

Bulletin of Experimental Biology and Medicine, 2017
Testing for substance toxicity for living organisms is an important step in the development and adaptation of new drugs for various purposes. Analysis of the dependences between toxicological parameters of chemical substances for various test objects and physicochemical properties of these agents is a promising trend. Partition coefficient logP (logKow)
K V, Zolotarev, K V, Nakhod, A N, Mikhailov, M V, Mikhailova   +3 more
openaire   +2 more sources

Estimators for the LC50.

1988
Dit rapport geeft een kritisch overzicht van statistische methoden voor het schatten van de LC50. Met name wordt aandacht besteed aan de bruikbaarheid van deze methoden bij het type gegevens dat bij toxiciteitstoetsen vaak voorkomt.
Hoekstra, JA
openaire   +3 more sources

A QSAR model for predicting toxicity (LC50) to rainbow trout

Water Research, 2002
A fragment constant method for prediction of toxicity (LC50) to rainbow trout was developed based on the experimental LC50 values of 258 chemicals obtained from the literature. The dataset was randomly divided into a training set and a validation set for purposes of model development and validation.
S, Tao, Xiaohuan, Xi, Fuliu, Xu, Richard, Dawson   +3 more
openaire   +2 more sources

Chlorosilane Acute Inhalation Toxicity and Development of an LC50 Prediction Model

Inhalation Toxicology, 2006
The acute inhalation toxicity of 10 chlorosilanes was investigated in Fischer 344 rats using a 1-h whole-body vapor inhalation exposure and a 14-day recovery period. The median lethal concentration (LC50(1)) for each material was calculated from the nominal exposure concentrations and mortality.
Paul A, Jean, Robert H, Gallavan, Gary B, Kolesar, Waheed H, Siddiqui, Jon A, Oxley, Robert G, Meeks   +5 more
openaire   +2 more sources

Methods for Calculating an LC50

1977
A variety of graphical and computational methods can be used to derive a median lethal concentration (LC50) from concentration-mortality data produced by an acute mortality test. In the selection of a method, practical considerations should receive as much attention as the usual theoretical and statistical considerations.
openaire   +1 more source

LC50 test results in polychlorinated biphenylfed mink: Age, season, and diet comparisons

Archives of Environmental Contamination and Toxicology, 1986
The toxicity of a polychlorinated biphenyl (PCB) mixture (Aroclor® 1254) to mink (Mustela vison) was evaluated through three dietary LC50 tests. These tests were designed to assess the effects of age of the test animals, composition of the diet, and season and year on the results of 28-day dietary LC50 tests.
T C, Hornshaw, J, Safronoff, R K, Ringer, R J, Aulerich   +3 more
openaire   +2 more sources

Measuring cytotoxicity: a new perspective on LC50.

Anticancer research, 2007
Cytotoxicity in cell culture is typically expressed as LC50 the concentration of a given agent which is lethal to 50% of the cells. This number is dependent on the incubation time with the agent. Previously, a two-term exponential model has been proposed to describe cell growth after a cytotoxic event: y(t) = k, * exp(-d(1)*t) + k2 * exp(d(2)*t).
Ming, Zhang, Dolly, Aguilera, Chandra, Das, Hernan, Vasquez, Peter, Zage, Vidya, Gopalakrishnan, Johannes, Wolff   +6 more
openaire   +1 more source