Results 91 to 100 of about 22,977 (188)

Low-Complexity Reduced-Rank Beamforming Algorithms [PDF]

, 2013
A reduced-rank framework with set-membership filtering (SMF) techniques is presented for adaptive beamforming problems encountered in radar systems.
de Lamare, R. C., Wang, L.
core  

NP and L Proteins of Lymphocytic Choriomeningitis Virus (LCMV) Are Sufficient for Efficient Transcription and Replication of LCMV Genomic RNA Analogs [PDF]

Journal of Virology, 2000
ABSTRACT The genome of lymphocytic choriomeningitis virus (LCMV) consists of two negative-sense single-stranded RNA segments, designated L and S. Both segments contain two viral genes in an ambisense coding strategy, with the genes being separated by an intergenic region (IGR).
K J, Lee, I S, Novella, M N, Teng, M B, Oldstone, J C, de La Torre   +4 more
openaire   +2 more sources

Immunometabolic and Spatiotemporal Control of Tissue‐Resident Memory T Cell Biology

Barrier Immunity, Volume 2, Issue 1, Page 6-22, March 2026.
Tissue‐resident memory T (TRM) cells in barrier tissues provide a frontline defense against invading pathogens. Immune (Signals 1–3) and nutrient (Signal 4) cues play an integral role in directing TRM formation and heterogeneity. The spatial and temporal organization of these signals establishes durable TRM cells across tissues, enabling diverse ...
Jana L. Raynor, Hongbo Chi
wiley   +1 more source

Lymphocytic Choriomeningitis Virus–associated Meningitis, Southern Spain

Emerging Infectious Diseases, 2012
Lymphocytic choriomeningitis virus (LCMV) was detected in 2 patients with acute meningitis in southern Spain within a 3-year period. Although the prevalence of LCMV infection was low (2 [1.3%] of 159 meningitis patients), it represents 2.9% of all ...
Mercedes Pérez-Ruiz, José-María Navarro-Marí, María-Paz Sánchez-Seco, María-Isabel Gegúndez, Gustavo Palacios, Nazir Savji, W. Ian Lipkin, Giovanni Fedele, Fernando de Ory-Manchón   +8 more
doaj   +1 more source

Immune Exhaustion in Chronic Infection and Cancer: Signaling Pathways and Therapeutic Interventions

MedComm, Volume 7, Issue 3, March 2026.
Immune exhaustion is a well‐established hallmark of both cancer and chronic infection. This review proposes a novel “infection–exhaustion–tumor axis” framework, wherein chronic pathogens (e.g., oncogenic viruses) evade immune surveillance by hijacking inflammatory signaling to drive immune cell exhaustion, thereby creating immunosuppressive niches ...
Yali Song, Yazhi Mo, Si Chen, Yuemei Chen, Chunying Zhang, Shanying Deng, Juan Liao, Yi He, Wei Wang, Weidong Zheng, Tingting Zeng   +10 more
wiley   +1 more source

A specific microbial consortium enhances Th1 immunity, improves LCMV viral clearance but aggravates LCMV disease pathology in mice

Nature Communications
Abstract Anti-viral immunity can vary tremendously from individual to individual but mechanistic understanding is still scarce. Here, we show that a defined, low complex bacterial community (OMM12) but not the general absence of microbes in germ-free mice leads to a more potent immune response compared to the microbiome of specific-pathogen ...
Daphne Kolland, Miriam Kuhlmann, Gustavo P. de Almeida, Amelie Köhler, Anela Arifovic, Alexandra von Strempel, Mohsen Pourjam, Silvia Bolsega, Christine Wurmser, Katja Steiger, Marijana Basic, Klaus Neuhaus, Carsten B. Schmidt-Weber, Bärbel Stecher, Dietmar Zehn, Caspar Ohnmacht   +15 more
openaire   +3 more sources

The JAK/STAT Pathway in Cancer: From Molecular Mechanisms to Clinical Applications

MedComm – Oncology, Volume 5, Issue 1, March 2026.
Dysregulated JAK/STAT signaling and related genetic mutations are strongly associated with cancer progression, including promoting tumor proliferation, suppressing apoptosis, inducing immune suppression, participating in drug resistance. Based on the function of the JAK/STAT pathway in disease pathogenesis, numerous agents targeting the JAK/STAT ...
Yixing Liao, Qi Wei, Hongjun Song, Hao Zeng, Chang Qi, Yunchang Meng, Yuanyuan Zhang, Yuanyuan Zhang, Weimin Li, Yalun Li, Panwen Tian   +10 more
wiley   +1 more source

Electrophysiological sexual dimorphism as an early risk marker of alcohol use in adolescence: A longitudinal neuroimaging study

Addiction, Volume 121, Issue 3, Page 606-616, March 2026.
Abstract Aims To identify the brain activity profiles associated with alcohol consumption and to address its causes. Furthermore, we sought to examine the relationship between these electrophysiological markers and the excitation–inhibition balance, as well as to explore the potential moderating role of sex in these associations.
Alberto del Cerro‐León, Marcos Uceta, Danylyna Shpakivska‐Bilan, Isabel Suárez‐Méndez, Héctor Peribáñez‐Baz, Pablo Cuesta, Ricardo Bruña, Luis M. García‐Moreno, Fernando Maestú, Luis Fernando Antón‐Toro   +9 more
wiley   +1 more source

The impact of Foxp3+ regulatory T‐cells on CD8+ T‐cell dysfunction in tumour microenvironments and responses to immune checkpoint inhibitors

British Journal of Pharmacology, Volume 183, Issue 6, Page 1250-1270, March 2026.
Immune checkpoint inhibitors (ICIs) have been a breakthrough in cancer therapy, inducing durable remissions in responding patients. However, they are associated with variable outcomes, spanning from disease hyperprogression to complete responses with the onset of immune‐related adverse events.
Mikhaël Attias, Ciriaco A. Piccirillo
wiley   +1 more source

The re-emergence and evolution of lymphocytic choriomeningitis virus in Germany

International Journal of Infectious Diseases
Introduction: Lymphocytic choriomeningitis virus (LCMV; species Mammarenavirus choriomeningitidis), a zoonotic pathogen transmitted by house mice (Mus musculus), is the only globally distributed arenavirus.
Mr Calvin Mehl, Claudia Wylezich, Olayide Abraham Adeyemi, Fiona Joana Möhrer, Romy Kerber, Daniel Cadar, Lisa Oestereich, Christina Geiger, Nicole Schauerte, Kerstin Mätz-Rensing, Anne Nesseler, Katja Schmidt, Dirk Höper, Miriam Linnenbrink, Martin Beer, Gerald Heckel, Rainer G. Ulrich   +16 more
doaj   +1 more source