We investigated the extent of lymphocytic choriomeningitis virus (LCMV) infection in employees and rodents at 3 commercial breeding facilities. Of 97 employees tested, 31 (32%) had IgM and/or IgG to LCMV, and aseptic meningitis was diagnosed in 4 ...
Barbara Knust +23 more
doaj +1 more source
Post-translational processing of the glycoproteins of lymphocytic choriomeningitis virus. [PDF]
Intracellular events in the synthesis, glycosylation, and transport of the lymphocytic choriomeningitis virus (LCMV) glycoproteins have been examined. We have shown by N-glycanase digestion that LCMV strain Arm-4 bears five oligosaccharides on GP-1 and ...
Buchmeier, MJ +3 more
core
Mixed Signals: T Cells as Architects of IgE Immunity
ABSTRACT Food allergen‐specific IgE can cause significant pathology, yet the pathways that generate pathogenic, high‐affinity IgE remain incompletely understood. Increasing evidence suggests that IgE responses arise from the integration of multiple, and sometimes opposing, T cell–derived cues.
Abigail L. Tierney +3 more
wiley +1 more source
Alloreactive cytotoxic T lymphocytes generated in the presence of viral- derived peptides show exquisite peptide and MHC specificity [PDF]
The nature of alloreactivity to MHC molecules has been enigmatic, primarily because of the observation that allogeneic responses are considerably stronger than syngeneic responses. To better determine the specificity potential of allogeneic responses, we
Alexander-Miller, M. A. +4 more
core
Human cases of lymphocytic choriomeningitis virus (LCMV) infections in Hungary
Abstract Lymphocytic choriomeningitis (LCM) is a “neglected” rodent-borne viral zoonotic disease caused by lymphocytic choriomeningitis virus (LCMV) (family Arenaviridae ). The aim of this retrospective clinical and laboratory study was to detect LCMV RNA, using RT-PCR, in ...
Peter Pankovics +6 more
openaire +2 more sources
PD‐L1‐Binding Antigen Presenters: Redirecting Vaccine‐Induced Antibodies for Cancer Immunotherapy
The PBAP‐gE complex anchors gE antigen to PD‐L1 on tumor cells. Vaccine‐induced anti‐gE antibodies simultaneously engage FcγRIIIa on NK cells and tumor‐bound PBAP‐gE, triggering NK cell activation and antibody‐dependent cellular cytotoxicity, thereby selectively eliminating PD‐L1–expressing tumor cells.
Huixin Gao +24 more
wiley +1 more source
Infectious diseases and autoimmunity [PDF]
Introduction: Autoimmunity occurs when the immune system recognizes and attacks host tissue. In addition to genetic factors, environmental triggers (in particular viruses, bacteria and other infectious pathogens) are thought to play a major role in the ...
Deidda, Silvia +3 more
core +1 more source
Both Systemic and Mucosal LCMV Immunization Generate Robust Viral-Specific IgG in Mucosal Secretions, But Elicit Poor LCMV-Specific IgA [PDF]
Immunoglobulins in secretions play a critical role in protection at mucosal surfaces. We examined the generation of viral-specific IgG and IgA in plasma and mucosal secretions of mice following systemic or mucosal immunization with lymphocytic choriomeningitis virus (LCMV), a widely used experimental model of viral infection.
Bheemreddy, Rajini +4 more
openaire +2 more sources
Uncovering Immune Niches in Health and Disease Using Spatial Transcriptomics
Through the lens of spatial transcriptomics and associated tools, novel immune niche constituents can now be resolved. Drawing on gut and tumor contexts, we propose a framework to define immune niches and integrate clonal dynamics, aiming to advance niche‐directed therapies toward precise, context‐specific immune modulation.
Johan Thorsson +3 more
wiley +1 more source
Prenatal Diagnosis of Congenital Lymphocytic Choriomeningitis Virus Infection: A Case Report
Lymphocytic choriomeningitis virus (LCMV) is an emerging neuroteratogen which can infect humans via contact with urine, feces, saliva, or blood of infected rodents.
Fanny Tevaearai +2 more
doaj +1 more source

