Results 51 to 60 of about 22,977 (188)

Distributed Node-Specific LCMV Beamforming in Wireless Sensor Networks [PDF]

IEEE Transactions on Signal Processing, 2012
In this paper, we consider the linearly constrained distributed adaptive node-specific signal estimation (LC-DANSE) algorithm, which generates a node-specific linearly constrained minimum variance (LCMV) beamformer, i.e., with node-specific linear constraints, at each node of a wireless sensor network.
Bertrand, Alexander, Moonen, Marc
openaire   +1 more source

RING Finger Z Protein of Lymphocytic Choriomeningitis Virus (LCMV) Inhibits Transcription and RNA Replication of an LCMV S-Segment Minigenome [PDF]

Journal of Virology, 2001
ABSTRACT Arenaviruses have a bisegmented negative-strand RNA genome whose proteomic capability is limited to only four polypeptides, namely, nucleoprotein (NP), surface glycoprotein (GP) that is proteolytically processed into GP1+GP2, polymerase (L), and a small (11-kDa) RING finger protein (Z). The role of Z during the
T I, Cornu, J C, de la Torre
openaire   +2 more sources

T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities

Advanced Science, EarlyView.
T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu, Xiaoyu Yao, Qingyang Wang, Mengrui Yang, Runze Li, Jiangjiang Qin, Jing Zhuang, Changgang Sun   +7 more
wiley   +1 more source

Pathogenic and Apathogenic Strains of Lymphocytic Choriomeningitis Virus Have Distinct Entry and Innate Immune Activation Pathways

Viruses
Lymphocytic choriomeningitis virus (LCMV) and Lassa virus (LASV) share many genetic and biological features including subtle differences between pathogenic and apathogenic strains.
Dylan M. Johnson, Nittaya Khakhum, Min Wang, Nikole L. Warner, Jenny D. Jokinen, Jason E. Comer, Igor S. Lukashevich   +6 more
doaj   +1 more source

Studying Macromolecular Composition in Cell–Cell Interfaces Using 3D Membrane Reconstitution Systems

Advanced Science, EarlyView.
A comprehensive understanding of the interactions between proteins, lipids and glycocalyx components at the immune synapse is still lacking. Here, an artificial and a semi‐artificial model contact system were established to reconstitute the cell‐cell contact in 3D. The model systems enable the examination of macromolecule enrichment or depletion at the
Franziska Ragaller, Amelie Maribel Schneider, Ellen Sjule, Renhua Sun, Xiao Han, Luca Andronico, Edward Jenkins, Michael Dustin, Adnane Achour, Erdinc Sezgin   +9 more
wiley   +1 more source

PD-1 signaling promotes control of chronic viral infection by restricting type-I-interferon-mediated tissue damage [PDF]

, 2019
Immune responses are essential for pathogen elimination but also cause tissue damage, leading to disease or death. However, it is unclear how the host immune system balances control of infection and protection from the collateral tissue damage.
Egawa, Takeshi, Raju, Saravanan, Verbaro, Daniel J   +2 more
core   +1 more source

Spatial heterogeneity and peptide availability determine CTL killing efficiency in vivo [PDF]

, 2014
The rate at which a cytotoxic T lymphocyte (CTL) can survey for infected cells is a key ingredient of models of vertebrate immune responses to intracellular pathogens. Estimates have been obtained using in vivo cytotoxicity assays in which peptide-pulsed
A Wiedemann, A Yates, AJ Yates, AL DeVico, AM Beal, AM Byers, Andrew Yates, AS Perelson, AS Perelson, AS Perelson, AS Perelson, B Breart, Benedict Seddon, Bjoern Peters, CA Macken, D Zagury, DH Busch, DL Barber, EA Grimm, ER Christinck, F Graw, F Graw, G Chu, LG Guidotti, M Bajénoff, M Poe, MA Purbhoo, MH Foley, MR Jenkins, P Perez, RR Regoes, RR Regoes, S Budhu, S Valitutti, SE Henrickson, SH van der Burg, Sim Tung, Thea Hogan, TR Mempel, Ulrich Kadolsky, VV Ganusov, VV Ganusov, VV Ganusov, VV Ganusov, W Barchet, Y Sykulev, YW Jung   +46 more
core   +4 more sources

Sleep magnetoencephalography enhances detection and source imaging of seizures and fast oscillations in focal cortical dysplasia

Epilepsia, EarlyView.
Abstract Objective Focal cortical dysplasia (FCD) causes drug‐resistant epilepsy requiring presurgical evaluation. Invasive electroencephalographic (EEG) studies demonstrate that sleep modulates epileptic activity, including interictal epileptiform discharges (IEDs), fast oscillations (FOs) in the beta (14–40 Hz) and gamma (40–80 Hz) frequency bands ...
Marcel Heers, Jawata Afnan, Christoph Braun, Christophe Grova, Dirk‐Matthias Altenmüller, Bernhard J. Steinhoff, Matthias Dümpelmann, Theo Demerath, Horst Urbach, Silke Ethofer, Markus Siegel, Andreas Schulze‐Bonhage, Holger Lerche, Yiwen Li Hegner   +13 more
wiley   +1 more source

Correlations in the T Cell Response to Altered Peptide Ligands

, 2004
The vertebrate immune system is a wonder of modern evolution. Occasionally, however, correlations within the immune system lead to inappropriate recruitment of preexisting T cells against novel viral diseases.
Arstila, Bachmann, Bachmann, Blattman, Bogarad, Chandler, Deem, Derrida, Derrida, Drossel, Garboczi, Garcia, Jeong-Man Park, Kauffman, Kedl, Kesmir, Klenerman, Lee, Lee, Martin, Michael W. Deem, Perelson, Perelson, Schodin, Singh, Sloan-Lancaster, Sourdive   +26 more
core   +1 more source

Reduced-Rank STAP Schemes for Airborne Radar Based on Switched Joint Interpolation, Decimation and Filtering Algorithm [PDF]

, 2010
In this paper, we propose a reduced-rank space-time adaptive processing (STAP) technique for airborne phased array radar applications. The proposed STAP method performs dimensionality reduction by using a reduced-rank switched joint interpolation ...
de Lamare, R.C., Fa, R., Wang, L.
core   +1 more source