Results 31 to 40 of about 4,532 (131)

Prevalence and Risk Factors for Lymphocytic Choriomeningitis Virus Infection in Continental Croatian Regions

Tropical Medicine and Infectious Disease, 2021
Lymphocytic choriomeningitis virus (LCMV) is a neglected human pathogen associated with aseptic meningitis, severe systemic infections in immunocompromised persons, and congenital anomalies. Data on the prevalence of LCMV infections are scarce.
Tatjana Vilibic-Cavlek, Tena Oreski, Misa Korva, Branko Kolaric, Vladimir Stevanovic, Snjezana Zidovec-Lepej, Irena Tabain, Pavle Jelicic, Bozana Miklausic-Pavic, Vladimir Savic, Ljubo Barbic, Tatjana Avsic-Zupanc   +11 more
doaj   +1 more source

Plasma Membrane Lipid Asymmetry Dynamically Regulates Passive Diffusion

Advanced Science, EarlyView.
Passive diffusion enables hydrophobic molecules to cross the plasma membrane and exert their biological functions. This study demonstrates that plasma membrane lipid asymmetry, dynamically regulated by lipid scrambling, determines membrane permeability to lipophilic molecules and thereby modulates their cellular activities.
Jieming Ping, Wenliang Wang, Jinnuo Xu, Mengyun Yang, Ning Wu   +4 more
wiley   +1 more source

Reduced numbers of LCMV-specific CD8+ T cells in the livers of LCMV-infected CIITA−/− mice.

, 2014
C57BL/6 and CIITA−/− mice were infected with 106 FFU LCMV-WE. At day 12 or 15 after infection, the numbers of LCMV-gp33 specific CD8+ T cells in spleen and liver of C57BL/6 and CIITA−/− mice were determined by staining with LCMV-gp33 loaded H-2Db ...
Antonella Carambia (511798), Tanja Trautmann (511796), Hans-Willi Mittrücker (511801), Johannes Herkel (270468), Jan-Hendrik Kozik (511797), Christiane Wiegard (511802), Kirsten Richter (146142), Dorothee Schwinge (511800), Ansgar W. Lohse (393407), Annette Oxenius (141998), Timo Lischke (511799)   +10 more
core   +1 more source

Artificial Intelligence for Identifying Tumor‐Reactive CD8+ T Cells: Biological Principles, Computational Advances, and Future Directions

Med Research, EarlyView.
This review details a three‐stage paradigm shift for tumor‐reactive CD8+ T‐cell identification: decoding transcriptomic states, deciphering clonal functional efficacy, and molecular‐level therapeutic TCR design. Addressing translational hurdles and generative AI “scientific blind spots”—such as missing catch bonds—we present a visionary roadmap.
Chao Yang, Yingying Sun, Yan Zhang, Yifen Shi, Zhiwen Shi   +4 more
wiley   +1 more source

Macrophage and T cell produced IL-10 promotes viral chronicity. [PDF]

PLoS Pathogens, 2013
Chronic viral infections lead to CD8(+) T cell exhaustion, characterized by impaired cytokine secretion. Presence of the immune-regulatory cytokine IL-10 promotes chronicity of Lymphocytic Choriomeningitis Virus (LCMV) Clone 13 infection, while absence ...
Kirsten Richter, Guillaume Perriard, Rayk Behrendt, Reto A Schwendener, Veronika Sexl, Robert Dunn, Masahito Kamanaka, Richard A Flavell, Axel Roers, Annette Oxenius   +9 more
doaj   +1 more source

Drivers of Host–Pathogen Community Assemblages in European Forests and Urban Green Spaces

Integrative Zoology, EarlyView.
ABSTRACT Despite advances in understanding infectious diseases, the persistence and re‐emergence of wildlife pathogens continue to raise public and veterinary health concerns. This study investigates the relationship between biodiversity and rodent‐borne diseases in Europe, focusing on habitat alterations and their impact on rodent diversity.
Vincent Sluydts, Marie Bouilloud, Maxime Galan, Hussein Alburkat, Anaïs Bordes, Vincent Bourret, Valeria Colombo, Luc DeBruyn, Lara Dutra, Jana Eccard, Jasmin Firozpoor, Romain Gallet, Maciej Grzybek, Heikki Henttonen, Jens Jacob, Andrew McManus, Tarja Sironen, Peter Stuart, Caroline Tatard, Benjamin Roche, Herwig Leirs, Nathalie Charbonnel   +21 more
wiley   +1 more source

Therapeutic potential of natural products in cancer immunotherapy: Advances and challenges

British Journal of Pharmacology, EarlyView.
This review systematically outlines the mechanisms underlying tumour immunotherapy resistance and elucidates the role of natural products in enhancing therapeutic efficacy as immunomodulatory adjuvants. Abstract Immunotherapy has emerged as a clinically pivotal approach in cancer treatment, but its application remains limited to a small subset of ...
Rao Hu, Kaibin Dai, Zhensheng Lin, Mingfang Ye, Minfeng Chen, Xiaobo Li, Dongmei Zhang   +6 more
wiley   +1 more source

Lymphocytic Choriomeningitis Virus (LCMV): Propagation, Quantitation, and Storage

, 2008
Lymphocytic choriomeningitis virus (LCMV) is an enveloped, ambisense RNA virus and the prototypic virus of the arenavirus group. It can cause viral meningitis and other ailments in humans, but its natural host is the mouse.
Raymond M. Welsh, Seedhom, Mina O., Mina O. Seedhom, Welsh, Raymond M.   +3 more
core   +1 more source

Cellular endosomal potassium ion flux regulates arenavirus uncoating during virus entry

mBio
Lymphocytic choriomeningitis virus (LCMV) is an enveloped and segmented negative-sense RNA virus classified within the Arenaviridae family of the Bunyavirales order.
Amelia B. Shaw, Hiu Nam Tse, Owen Byford, Grace Plahe, Alex Moon-Walker, Samantha E. Hover, Erica Ollmann Saphire, Sean P. J. Whelan, Jamel Mankouri, Juan Fontana, John N. Barr   +10 more
doaj   +1 more source

A guide to studying tumour‐T‐cell interactions using in vitro coculture assays

The FEBS Journal, EarlyView.
In vitro tumour‐T‐cell coculture systems provide a controlled way to study how T cells recognise and kill tumour cells. Different tumour models can be combined with antigen‐specific TCR or CAR T cells, while antigen presentation, cytokines, drugs and tumour genetics can be manipulated.
Nooshin Khoshdoozmasouleh, Conor J. Kearney   +1 more
wiley   +1 more source