Results 21 to 30 of about 4,532 (131)

CD8⁺ T cells that have undergone their first division in response to LCMV-Arm vs. LCMV-Cl13 exhibit phenotypic and transcriptional heterogeneity.

, 2023
(A) Heatmaps representing relative gene expression of the three Division 1 clusters, Div1ARM-EFF, Div1ARM-MEM, and Div1CL13, divided by category; rows represent selected genes and columns represent each of three Division 1 clusters. (B) Enriched pathways
Lara Labarta-Bajo (9096773), Elina I. Zuniga (5559230), Cynthia S. Indralingam (14522579), Christopher Hattori (14522591), John T. Chang (13864200), Lauren K. Quezada (14522564), Yi Chia Liu (14522570), Zhaoren He (14522576), Ellen J. Wehrens (14522585), Katelynn R. Kazane (14522588), Wenhao Jin (14522567), Gene W. Yeo (260262), Tiffani Tysl (14522582), Yeara Jo (2053420), Eleanor S. Kim (14522573)   +14 more
core   +1 more source

IL-6 and IL-27 play both distinct and redundant roles in regulating CD4 T-cell responses during chronic viral infection

Frontiers in Immunology, 2023
The IL-6 cytokine family signals through the common signal transduction molecule gp130 combined with a cytokine-specific receptor. Gp130 signaling on CD4 T cells is vital in controlling chronic infection of mice with lymphocytic choriomeningitis virus ...
James A. Harker, James A. Harker, Trever T. Greene, Burton E. Barnett, Phuc Bao, Aleksandr Dolgoter, Elina I. Zuniga   +6 more
doaj   +1 more source

Discovery of a novel lymphocytic choriomeningitis virus strain associated with severe human disease in immunocompetent patient, New Mexico

Emerging Microbes and Infections
Lymphocytic choriomeningitis virus (LCMV) is an underreported emerging pathogen and was recently included as a National Institute of Allergy and Infectious Disease (NIAID) priority pathogen.
Jordan T. Gass, Robert A. Nofchissey, Frances M. Twohig, Chunyan Ye, Samuel M. Goodfellow, Kimiknu Mentore, Marcos Burgos, Oscar Negrete, Shannon Whitmer, John D. Klena, Deborah Cannon, Leanna Sayyad, Steven B. Bradfute   +12 more
doaj   +1 more source

Lymphocytic Choriomeningitis Virus Infection Demonstrates Higher Replicative Capacity and Decreased Antiviral Response in the First-Trimester Placenta

Journal of Immunology Research, 2019
Lymphocytic choriomeningitis virus (LCMV) is a rodent disease that can be transmitted to humans. A majority of persons infected with LCMV have only minor symptoms; however, it can cross the placental barrier during pregnancy and cause congenital defects ...
Elizabeth Ann L. Enninga, Regan N. Theiler   +1 more
doaj   +1 more source

Lymphocytic choriomeningitis virus meningitis after needlestick injury: a case report

Antimicrobial Resistance and Infection Control, 2019
Background Needlestick accidents while handling of infectious material in research laboratories can lead to life-threatening infections in laboratory personnel.
Sarah Dräger, Anna-Friederike Marx, Fiona Pigny, Pascal Cherpillod, Philip Eisermann, Parham Sendi, Andreas F. Widmer   +6 more
doaj   +1 more source

Identification of the lymphocytic choriomeningitis virus (LCMV) proteins required to rescue LCMV RNA analogs into LCMV-like particles

, 2002
We have used a reverse genetic approach to identify the viral proteins required for packaging and assembly of the prototypic arenavirus lymphocytic choriomeningitis virus (LCMV).
Perez, Mar, Pinschewer, Daniel D., de la Torre, Juan Carlos, Lee, Ki Jeong   +3 more
core   +1 more source

Congenital viral infections of the brain: lessons learned from lymphocytic choriomeningitis virus in the neonatal rat.

PLoS Pathogens, 2007
The fetal brain is highly vulnerable to teratogens, including many infectious agents. As a consequence of prenatal infection, many children suffer severe and permanent brain injury and dysfunction. Because most animal models of congenital brain infection
Daniel J Bonthius, Stanley Perlman
doaj   +1 more source

Genome-Wide Knockout Screen Identifies Human Sialomucin CD164 as an Essential Entry Factor for Lymphocytic Choriomeningitis Virus

mBio, 2022
Lymphocytic choriomeningitis virus (LCMV) is a well-studied mammarenavirus that can be fatal in congenital infections. However, our understanding of LCMV and its interactions with human host factors remains incomplete.
Jamin Liu, Kristeene A. Knopp, Elze Rackaityte, Chung Yu Wang, Matthew T. Laurie, Sara Sunshine, Andreas S. Puschnik, Joseph L. DeRisi   +7 more
doaj   +1 more source

Confirmation of RV-N and LCMV-GP expression.

, 2018
BHK-P cells were inoculated with RVΔP-LCMV/GPC (A–C) or RVΔP (D–F) at an MOI of 0.1 and incubated at 33°C for 48 h. Cells were stained with anti-RV N mAb or the anti-LCMV-GP1 mAb. Original magnification, 400×. (G–I) RV-N and the LCMV-GPC were detected in
Md. Taimur Islam (5104844), Yukie Yamaguchi (144018), Hirofumi Kato (2726779), Itoe Iizuka (5104850), Guillermo Posadas-Herrera (5104847), Mutsuyo Takayama-Ito (5104853), Kinjiro Morimoto (306686), Chang-Kweng Lim (181621), Masayuki Saijo (324701)   +8 more
core   +1 more source

Pathogenic and Apathogenic Strains of Lymphocytic Choriomeningitis Virus Have Distinct Entry and Innate Immune Activation Pathways

Viruses
Lymphocytic choriomeningitis virus (LCMV) and Lassa virus (LASV) share many genetic and biological features including subtle differences between pathogenic and apathogenic strains.
Dylan M. Johnson, Nittaya Khakhum, Min Wang, Nikole L. Warner, Jenny D. Jokinen, Jason E. Comer, Igor S. Lukashevich   +6 more
doaj   +1 more source